异银杏双黄酮

Isoginkgetin

	产品编号	CFN90174
	CAS编号	548-19-6
	分子式 = 分子量	C₃₂H₂₂O₁₀ = 566.51
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The leaves of Ginkgo biloba L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
异银杏双黄酮	CFN90174	548-19-6	10mg	QQ客服：215959384
异银杏双黄酮	CFN90174	548-19-6	20mg	QQ客服：215959384
异银杏双黄酮	CFN90174	548-19-6	50mg	QQ客服：215959384
异银杏双黄酮	CFN90174	548-19-6	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sri Ramachandra University (India)

Universite de Lille1 (France)

University of Maryland (USA)

Massachusetts General Hospital (USA)

National Chung Hsing University (Taiwan)

Ateneo de Manila University (Philippines)

Uniwersytet Medyczny w ?odzi (Poland)

Tokyo Woman's Christian University (Japan)

Osmania University (India)

University of Leipzig (Germany)

Chiang Mai University (Thailand)

Universidad de Ciencias y Artes de Chiapas (Mexico)

University of Wuerzburg (Germany)

John Innes Centre (United Kingdom)

More...

Description:

Isoginkgetin is a MMP-9 inhibitor, also a pre-mRNA splicing inhibitor with IC 50 of 30 uM. Isoginkgetin can up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. Isoginkgetin has anti-tumor activity, it can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression.

Targets:

MMP(e.g.TIMP) | PI3K | Akt | NF-kB | AMPK | SOD

In vitro:

J Biol Chem. 2008 Nov 28;283(48):33147-54.

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.[Pubmed: 18826947]

Membrane-permeable compounds that reversibly inhibit a particular step in gene expression are highly useful tools for cell biological and biochemical/structural studies. In comparison with other gene expression steps where multiple small molecule effectors are available, very few compounds have been described that act as general inhibitors of pre-mRNA splicing.
METHODS AND RESULTS:
Here we report construction and validation of a set of mammalian cell lines suitable for the identification of small molecule inhibitors of pre-mRNA splicing. Using these cell lines, we identified the natural product isoginkgetin as a general inhibitor of both the major and minor spliceosomes. Isoginkgetin inhibits splicing both in vivo and in vitro at similar micromolar concentrations. It appears to do so by preventing stable recruitment of the U4/U5/U6 tri-small nuclear ribonucleoprotein, resulting in accumulation of the prespliceosomal A complex. Like two other recently reported general pre-mRNA splicing inhibitors, isoginkgetin has been previously described as an anti-tumor agent.
CONCLUSIONS:
Our results suggest that splicing inhibition is the mechanistic basis of the anti-tumor activity of isoginkgetin. Thus, pre-mRNA splicing inhibitors may represent a novel avenue for development of new anti-cancer agents.

In vivo:

Traditional Chinese Drug Research & Clinical Pharmacology, 1993(2):12-4.

Effect of Isoginkgetin on Scavenge of Oxygen Free Radical in Anoxic Rats.[Reference: WebLink]

METHODS AND RESULTS:
Chemiluminescence method and modified nitrous acid method were applied to determine the concentration of superoxide anion radical in plasma and erythrocyte of rats and the activity of superoxide dismutase(SOD) respectively. The results showed that Isoginkgetin (0.3mg/kg ip for 3d) could reduce the level of O2·- in plasma and erythroeyte (p<0.01) and sometimes increase the activity of SOD in anoxic rats, the action being stronger than aspirin.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
金松双黄酮; Sciadopitysin	CFN98847	521-34-6	C₃₃H₂₄O₁₀ = 580.6	20mg	QQ客服：3257982914
7''-O-甲氧基金松双黄酮; 7''-O-Methylsciadopitysin	CFN96118	3778-25-4	C₃₄H₂₆O₁₀ = 594.6	5mg	QQ客服：2056216494
台湾高黄酮 A; Taiwanhomoflavone A	CFN96541	265120-00-1	C₃₃H₂₄O₁₀ = 580.55	5mg	QQ客服：1457312923
3,8''-联芹菜甙元; 3,8'-Biapigenin	CFN99025	101140-06-1	C₃₀H₁₈O₁₀ = 538.5	5mg	QQ客服：3257982914
GB 1a; GB 1a	CFN96934	220611-41-6	C₃₀H₂₂O₁₀ = 542.49	5mg	QQ客服：215959384
GB 1b; GB 1b	CFN89091	19360-72-6	C₃₀H₂₂O₁₀ = 542.49	5mg	QQ客服：2159513211
GB 2a; GB 2a	CFN89133	18412-96-9	C₃₀H₂₂O₁₁ = 558.49	5mg	QQ客服：2159513211
荛花醇A; Wikstrol A	CFN92960	159736-35-3	C₃₀H₂₂O₁₀ = 542.49	5mg	QQ客服：1413575084
柏木双黄酮; Cupressuflavone	CFN70356	3952-18-9	C₃₀H₁₈O₁₀ = 538.5	10mg	QQ客服：2056216494
4',4'''-双-O-甲基姜黄素; 4',4'''-Di-O-methylcupressuflavone	CFN97224	74336-91-7	C₃₂H₂₂O₁₀ = 566.5	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7652 mL	8.826 mL	17.6519 mL	35.3039 mL	44.1298 mL
5 mM	0.353 mL	1.7652 mL	3.5304 mL	7.0608 mL	8.826 mL
10 mM	0.1765 mL	0.8826 mL	1.7652 mL	3.5304 mL	4.413 mL
50 mM	0.0353 mL	0.1765 mL	0.353 mL	0.7061 mL	0.8826 mL
100 mM	0.0177 mL	0.0883 mL	0.1765 mL	0.353 mL	0.4413 mL