异银杏双黄酮
Isoginkgetin
|
|
产品编号 |
CFN90174 |
| CAS编号 |
548-19-6 |
| 分子式 = 分子量 |
C32H22O10 = 566.51 |
| 产品纯度 |
>=98% |
| 物理属性 |
Yellow powder |
| 化合物类型 |
Flavonoids |
| 植物来源 |
The leaves of Ginkgo biloba L. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 异银杏双黄酮 |
CFN90174 |
548-19-6 |
10mg |
QQ客服：2056216494 |
| 异银杏双黄酮 |
CFN90174 |
548-19-6 |
20mg |
QQ客服：2056216494 |
| 异银杏双黄酮 |
CFN90174 |
548-19-6 |
50mg |
QQ客服：2056216494 |
| 异银杏双黄酮 |
CFN90174 |
548-19-6 |
100mg |
QQ客服：2056216494 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
China Medical University (Taiwan)
University of Sao Paulo (Brazil)
University of Fribourg (Switzerland)
Complutense University of Madrid (Spain)
University of Mysore (India)
University of Maryland School of Medicine (USA)
University of South Australia (Australia)
University of Canterbury (New Zealand)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Sanford Burnham Medical Research Institute (USA)
Michigan State University (USA)
The Ohio State University (USA)
Instytut Nawozów Sztucznych w Pu?awach (Poland)
Max-Planck-Insitut (Germany)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Isoginkgetin is a MMP-9 inhibitor, also a pre-mRNA splicing inhibitor with IC 50 of 30 uM. Isoginkgetin can up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. Isoginkgetin has anti-tumor activity, it can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression.
|
| Targets: |
MMP(e.g.TIMP) | PI3K | Akt | NF-kB | AMPK | SOD |
| In vitro: |
| J Biol Chem. 2008 Nov 28;283(48):33147-54. | | The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.[Pubmed: 18826947] | Membrane-permeable compounds that reversibly inhibit a particular step in gene expression are highly useful tools for cell biological and biochemical/structural studies. In comparison with other gene expression steps where multiple small molecule effectors are available, very few compounds have been described that act as general inhibitors of pre-mRNA splicing.
METHODS AND RESULTS:
Here we report construction and validation of a set of mammalian cell lines suitable for the identification of small molecule inhibitors of pre-mRNA splicing. Using these cell lines, we identified the natural product isoginkgetin as a general inhibitor of both the major and minor spliceosomes. Isoginkgetin inhibits splicing both in vivo and in vitro at similar micromolar concentrations. It appears to do so by preventing stable recruitment of the U4/U5/U6 tri-small nuclear ribonucleoprotein, resulting in accumulation of the prespliceosomal A complex. Like two other recently reported general pre-mRNA splicing inhibitors, isoginkgetin has been previously described as an anti-tumor agent.
CONCLUSIONS:
Our results suggest that splicing inhibition is the mechanistic basis of the anti-tumor activity of isoginkgetin. Thus, pre-mRNA splicing inhibitors may represent a novel avenue for development of new anti-cancer agents. |
|
| In vivo: |
| Traditional Chinese Drug Research & Clinical Pharmacology, 1993(2):12-4. | | Effect of Isoginkgetin on Scavenge of Oxygen Free Radical in Anoxic Rats.[Reference: WebLink] |
METHODS AND RESULTS:
Chemiluminescence method and modified nitrous acid method were applied to determine the concentration of superoxide anion radical in plasma and erythrocyte of rats and the activity of superoxide dismutase(SOD) respectively. The results showed that Isoginkgetin (0.3mg/kg ip for 3d) could reduce the level of O2·- in plasma and erythroeyte (p<0.01) and sometimes increase the activity of SOD in anoxic rats, the action being stronger than aspirin. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.7652 mL |
8.826 mL |
17.6519 mL |
35.3039 mL |
44.1298 mL |
| 5 mM |
0.353 mL |
1.7652 mL |
3.5304 mL |
7.0608 mL |
8.826 mL |
| 10 mM |
0.1765 mL |
0.8826 mL |
1.7652 mL |
3.5304 mL |
4.413 mL |
| 50 mM |
0.0353 mL |
0.1765 mL |
0.353 mL |
0.7061 mL |
0.8826 mL |
| 100 mM |
0.0177 mL |
0.0883 mL |
0.1765 mL |
0.353 mL |
0.4413 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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