Info: Read More
  • 中药标准品生产商,产品定制服务
  • 异银杏双黄酮

    Isoginkgetin

    异银杏双黄酮
    产品编号 CFN90174
    CAS编号 548-19-6
    分子式 = 分子量 C32H22O10 = 566.51
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Ginkgo biloba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异银杏双黄酮 CFN90174 548-19-6 10mg QQ客服:215959384
    异银杏双黄酮 CFN90174 548-19-6 20mg QQ客服:215959384
    异银杏双黄酮 CFN90174 548-19-6 50mg QQ客服:215959384
    异银杏双黄酮 CFN90174 548-19-6 100mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Utrecht University (Netherlands)
  • University of Mysore (India)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Center for protein Engineering (CIP) (Belgium)
  • Agricultural Research Organization (ARO) (Israel)
  • Wageningen University (Netherlands)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Amsterdam (Netherlands)
  • University of Auckland (New Zealand)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • University of Madras (India)
  • Universidade do Porto (Portugal)
  • University of Helsinki (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules2022, 27(14):4601
  • Life Sci.2018, 209:498-506
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • Horticulture Research2020, 7:111.
  • Cells.2021, 10(10):2633.
  • Agronomy2020, 10(10),1489
  • Nanjing University of Chinese Medicine2022, 345930.
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • J Nat Prod.2022, doi: 10.1021
  • Appl. Sci.2020, 10(4),1304
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • Antioxidants (Basel).2022, 11(12):2411.
  • J Pharm Biomed Anal.2018, 151:32-41
  • Biomolecules.2020, 10(2):E184
  • Korean J Dent Mater2020, 47(2):63-70.
  • Mol Biol Rep.2022, doi: 10.1007
  • Molecules.2020, 25(18),4089.
  • Journal of Apiculture2019, 34(2):131-136
  • Asian Pac J Tropical Bio.2020, 10(6):239-247
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Molecules.2019, 24(10):E1930
  • University of Limpopo2016, 1777
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • ...
  • 生物活性
    Description: Isoginkgetin is a MMP-9 inhibitor, also a pre-mRNA splicing inhibitor with IC 50 of 30 uM. Isoginkgetin can up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. Isoginkgetin has anti-tumor activity, it can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression.
    Targets: MMP(e.g.TIMP) | PI3K | Akt | NF-kB | AMPK | SOD
    In vitro:
    J Biol Chem. 2008 Nov 28;283(48):33147-54.
    The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.[Pubmed: 18826947]
    Membrane-permeable compounds that reversibly inhibit a particular step in gene expression are highly useful tools for cell biological and biochemical/structural studies. In comparison with other gene expression steps where multiple small molecule effectors are available, very few compounds have been described that act as general inhibitors of pre-mRNA splicing.
    METHODS AND RESULTS:
    Here we report construction and validation of a set of mammalian cell lines suitable for the identification of small molecule inhibitors of pre-mRNA splicing. Using these cell lines, we identified the natural product isoginkgetin as a general inhibitor of both the major and minor spliceosomes. Isoginkgetin inhibits splicing both in vivo and in vitro at similar micromolar concentrations. It appears to do so by preventing stable recruitment of the U4/U5/U6 tri-small nuclear ribonucleoprotein, resulting in accumulation of the prespliceosomal A complex. Like two other recently reported general pre-mRNA splicing inhibitors, isoginkgetin has been previously described as an anti-tumor agent.
    CONCLUSIONS:
    Our results suggest that splicing inhibition is the mechanistic basis of the anti-tumor activity of isoginkgetin. Thus, pre-mRNA splicing inhibitors may represent a novel avenue for development of new anti-cancer agents.
    In vivo:
    Traditional Chinese Drug Research & Clinical Pharmacology, 1993(2):12-4.
    Effect of Isoginkgetin on Scavenge of Oxygen Free Radical in Anoxic Rats.[Reference: WebLink]

    METHODS AND RESULTS:
    Chemiluminescence method and modified nitrous acid method were applied to determine the concentration of superoxide anion radical in plasma and erythrocyte of rats and the activity of superoxide dismutase(SOD) respectively. The results showed that Isoginkgetin (0.3mg/kg ip for 3d) could reduce the level of O2·- in plasma and erythroeyte (p<0.01) and sometimes increase the activity of SOD in anoxic rats, the action being stronger than aspirin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7652 mL 8.826 mL 17.6519 mL 35.3039 mL 44.1298 mL
    5 mM 0.353 mL 1.7652 mL 3.5304 mL 7.0608 mL 8.826 mL
    10 mM 0.1765 mL 0.8826 mL 1.7652 mL 3.5304 mL 4.413 mL
    50 mM 0.0353 mL 0.1765 mL 0.353 mL 0.7061 mL 0.8826 mL
    100 mM 0.0177 mL 0.0883 mL 0.1765 mL 0.353 mL 0.4413 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    四氢阿曼托黄素; Tetrahydroamentoflavone CFN98755 48236-96-0 C30H22O10 = 542.5 5mg QQ客服:2159513211
    3',3'''-二柚皮素; 3',3'''-Binaringenin CFN95558 145399-99-1 C30H22O10 = 542.5 5mg QQ客服:1413575084
    穗花杉双黄酮; 阿曼托黄酮; Amentoflavone CFN99526 1617-53-4 C30H18O10 = 538.46 20mg QQ客服:2056216494
    7-去甲基银杏双黄酮; Bilobetin CFN98846 521-32-4 C31H20O10 = 552.5 20mg QQ客服:215959384
    苏铁双黄酮; Sotetsuflavone CFN93257 2608-21-1 C31H20O10 = 552.5 5mg QQ客服:1413575084
    银杏素; Ginkgetin CFN90173 481-46-9 C32H22O10 = 566.51 20mg QQ客服:215959384
    罗汉松黄酮A; Podocarpusflavone A CFN98202 22136-74-9 C31H20O10 = 552.5 5mg QQ客服:2159513211
    竹柏双黄酮B; Putraflavone CFN98246 23624-21-7 C32H22O10 = 566.5 5mg QQ客服:1413575084
    三叶橡胶黄酮; Heveaflavone CFN98236 23132-13-0 C33H24O10 = 580.6 5mg QQ客服:3257982914
    异银杏双黄酮; Isoginkgetin CFN90174 548-19-6 C32H22O10 = 566.51 20mg QQ客服:2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产