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  • 异银杏双黄酮

    • 异银杏双黄酮

    Isoginkgetin

    异银杏双黄酮
    		产品编号 CFN90174
    CAS编号 548-19-6
    分子式 = 分子量 C32H22O10 = 566.51
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Ginkgo biloba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异银杏双黄酮 CFN90174 548-19-6 10mg QQ客服：2159513211
    异银杏双黄酮 CFN90174 548-19-6 20mg QQ客服：2159513211
    异银杏双黄酮 CFN90174 548-19-6 50mg QQ客服：2159513211
    异银杏双黄酮 CFN90174 548-19-6 100mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • BMC Plant Biol.2021, 21(1):60.
  • Int J Mol Med.2020, 45(5):1514-1524.
  • Universitat Stuttgart2022, opus-12200.
  • Ajou University2024, 4688116
  • Phytomedicine.2015, 22(4):498-503
  • LWT2021, 150:112021.
  • Oncol Rep.2021, 46(2):166.
  • Hum Exp Toxicol.2023, 42:9603271221145386.
  • Phytomedicine.2021, 83:153483.
  • Int J Mol Sci.2022, 23(10):5813.
  • Sci Rep.2015, 5:13194
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Phytother Res.2019, 33(5):1490-1500
  • Foods2023, 12(23), 4342.
  • Front Plant Sci.2018, 9:1424
  • Mie University2019, 10076.
  • Preprints2017, 2017120176
  • Drug Chem Toxicol.2024, 1-10.
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • J Appl Biol Chem2021, 64(3):245-251.
  • BMC Plant Biol.2018, 18(1):122
  • ...
    • 生物活性
    Description: Isoginkgetin is a MMP-9 inhibitor, also a pre-mRNA splicing inhibitor with IC 50 of 30 uM. Isoginkgetin can up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. Isoginkgetin has anti-tumor activity, it can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression.
    Targets: MMP(e.g.TIMP) | PI3K | Akt | NF-kB | AMPK | SOD
    In vitro:
    J Biol Chem. 2008 Nov 28;283(48):33147-54.
    The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.[Pubmed: 18826947]
    Membrane-permeable compounds that reversibly inhibit a particular step in gene expression are highly useful tools for cell biological and biochemical/structural studies. In comparison with other gene expression steps where multiple small molecule effectors are available, very few compounds have been described that act as general inhibitors of pre-mRNA splicing.
    METHODS AND RESULTS:
    Here we report construction and validation of a set of mammalian cell lines suitable for the identification of small molecule inhibitors of pre-mRNA splicing. Using these cell lines, we identified the natural product isoginkgetin as a general inhibitor of both the major and minor spliceosomes. Isoginkgetin inhibits splicing both in vivo and in vitro at similar micromolar concentrations. It appears to do so by preventing stable recruitment of the U4/U5/U6 tri-small nuclear ribonucleoprotein, resulting in accumulation of the prespliceosomal A complex. Like two other recently reported general pre-mRNA splicing inhibitors, isoginkgetin has been previously described as an anti-tumor agent.
    CONCLUSIONS:
    Our results suggest that splicing inhibition is the mechanistic basis of the anti-tumor activity of isoginkgetin. Thus, pre-mRNA splicing inhibitors may represent a novel avenue for development of new anti-cancer agents.
    In vivo:
    Traditional Chinese Drug Research & Clinical Pharmacology, 1993(2):12-4.
    Effect of Isoginkgetin on Scavenge of Oxygen Free Radical in Anoxic Rats.[Reference: WebLink]

    METHODS AND RESULTS:
    Chemiluminescence method and modified nitrous acid method were applied to determine the concentration of superoxide anion radical in plasma and erythrocyte of rats and the activity of superoxide dismutase(SOD) respectively. The results showed that Isoginkgetin (0.3mg/kg ip for 3d) could reduce the level of O2·- in plasma and erythroeyte (p<0.01) and sometimes increase the activity of SOD in anoxic rats, the action being stronger than aspirin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7652 mL 8.826 mL 17.6519 mL 35.3039 mL 44.1298 mL
    5 mM 0.353 mL 1.7652 mL 3.5304 mL 7.0608 mL 8.826 mL
    10 mM 0.1765 mL 0.8826 mL 1.7652 mL 3.5304 mL 4.413 mL
    50 mM 0.0353 mL 0.1765 mL 0.353 mL 0.7061 mL 0.8826 mL
    100 mM 0.0177 mL 0.0883 mL 0.1765 mL 0.353 mL 0.4413 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8,8''-二黄芩素; 8,8''-Bibaicalein CFN95007 135309-02-3 C30H18O10 = 538.5 5mg QQ客服：215959384
    Acuminatanol; Acuminatanol CFN96555 948884-38-6 C30H22O16 = 638.49 5mg QQ客服：1457312923
    Isoacuminatanol; Isoacuminatanol CFN95766 2446349-77-3 C30H22O16 = 638.5 5mg QQ客服：3257982914
    2,3-Dihydroamentoflavone 7,4'-dimethyl ether; 2,3-Dihydroamentoflavone 7,4'-dimethyl ether CFN96163 873999-88-3 C32H24O10 = 568.5 5mg QQ客服：1457312923
    2,3-二羟基三叶橡胶黄酮; 2,3-Dihydroheveaflavone CFN96119 110382-42-8 C33H26O10 = 582.6 5mg QQ客服：215959384
    2,3-二羟基金松双黄酮; 2,3-dihydrosciadopitysin CFN96134 34421-19-7 C33H26O10 = 582.6 5mg QQ客服：215959384
    2,3-二氢罗汉松黄酮A; 2,3-Dihydropodocarpusflavone A CFN96378 852875-96-8 C31H22O10 = 554.5 5mg QQ客服：2056216494
    四氢阿曼托黄素; Tetrahydroamentoflavone CFN98755 48236-96-0 C30H22O10 = 542.5 5mg QQ客服：1413575084
    3',3'''-二柚皮素; 3',3'''-Binaringenin CFN95558 145399-99-1 C30H22O10 = 542.5 5mg QQ客服：1413575084
    穗花杉双黄酮； 阿曼托黄酮; Amentoflavone CFN99526 1617-53-4 C30H18O10 = 538.46 20mg QQ客服：2159513211

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