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  • 罗汉松黄酮A

    Podocarpusflavone A

    罗汉松黄酮A
    产品编号 CFN98202
    CAS编号 22136-74-9
    分子式 = 分子量 C31H20O10 = 552.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The barks of Podocarpus macrophyllus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    罗汉松黄酮A CFN98202 22136-74-9 1mg QQ客服:1413575084
    罗汉松黄酮A CFN98202 22136-74-9 5mg QQ客服:1413575084
    罗汉松黄酮A CFN98202 22136-74-9 10mg QQ客服:1413575084
    罗汉松黄酮A CFN98202 22136-74-9 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Utrecht University (Netherlands)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Leipzig (Germany)
  • University of Oslo (Norway)
  • Medizinische Universit?t Wien (Austria)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Eastern Finland (Finland)
  • China Medical University (Taiwan)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Chiang Mai University (Thailand)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Helmholtz Zentrum München (Germany)
  • Periyar University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2018, 19(2)
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Sci Rep.2018, 8:15059
  • Molecules.2019, 24(21):E3834
  • Drug Des Devel Ther.2020, 14:969-976.
  • Sustainability2021, 13(23),12981.
  • Institute of Food Science & Technology2021, 56(11).
  • J Pharm Biomed Anal.2019, 172:268-277
  • Front Microbiol.2021, 12:736780.
  • Korean Herb. Med. Inf.2021, 9(2):231-239.
  • Phytomedicine.2015, 22(4):498-503
  • Psychopharmacology (Berl).2020, 10.1007
  • Braz J Med Biol Res. 2016, 49(7)
  • Planta Med.2019, 85(4):347-355
  • US20170000760 A12016, 42740
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Sci Rep. 2017, 8207(7)
  • Phytother Res.2016, 30(12):2020-2026
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Biomolecules.2020, 10(6):925.
  • Br J Pharmacol.2018, 175(6):902-923
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • Molecules.2015, 20(11):20014-30
  • ...
  • 生物活性
    Description: Podocarpusflavone A is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever. Podocarpusflavone A also shows antimalarial activity in vitro against the chloroquine-sensitive F32 and chloroquine-resistant FcM29 strains of Plasmodium falciparum.
    Targets: DNA/RNA Synthesis | Antifection
    In vitro:
    Planta Med. 2012 May;78(7):672-7.
    Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase.[Pubmed: 22411725]
    In order to find new molecules for antiviral drug design, we screened 102 ethyl acetate extracts from New-Caledonian flora for antiviral activity against the dengue 2 virus RNA-dependant RNA polymerase (DV-NS5 RdRp).
    METHODS AND RESULTS:
    The leaf extract of Dacrydium balansae, which strongly inhibited the DV-NS5, was submitted to bioguided fractionation. Four biflavonoids ( 1- 4), three sterols ( 5- 7), and two stilbene derivatives ( 8- 9) were identified and evaluated for their antiviral potential on the DV-NS5 RdRp. Biflavonoids appeared to be potent inhibitors of DV-NS5 RdRp with IC (50)s between 0.26 and 3.12 µM. Inhibitory activity evaluations against the RNA polymerase from other Flaviviridae viruses allowed us to conclude that these compounds are specific inhibitors of the DV RNA polymerase. The strongest inhibitions were observed with hinokiflavone ( 4), but podocarpusflavone A ( 2) is the strongest noncytotoxic inhibitor of the DV-NS5 and it also displayed polymerase inhibitory activity in a DV replicon.
    CONCLUSIONS:
    A preliminary structure-activity relationship study (SARs) revealed the necessity of the biflavonoid skeleton, the influence of number and position of methoxylations, and the importance of a free rotation of the linkage between the two apigenin monomers of the biflavonoids. To the best of our knowledge, podocarpusflavone A ( 2) is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever.
    Ann Trop Med Parasitol. 2007 Jan;101(1):23-30.
    Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola (Guttiferae).[Pubmed: 17244407 ]

    METHODS AND RESULTS:
    Phytochemical investigation of the leaves of Allanblackia monticola led to the isolation and characterisation of five prenylated xanthones [1,6-dihydroxy-3,7-dimethoxy-2-(3-methylbut-2-enyl)xanthone 1, alpha-mangostin 2, tovophyllin A 3, allanxanthone C 4 and 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthone 5], two biflavonoid derivatives (amentoflavone 6 and Podocarpusflavone A 7) and one pentacyclic triterpene (friedelan-3-one 8). The structures of these compounds were established on the basis of homo- and hetero-nuclear, one- and two-dimensional, nuclear magnetic resonance. Compounds 2-8 and a crude methanolic extract of A. monticola leaves were each tested for antimalarial activity in vitro, using the chloroquine-sensitive F32 and chloroquine-resistant FcM29 strains of Plasmodium falciparum; the median inhibitory concentrations (IC(50)) recorded varied from 0.7 to 83.5 mug/ml. The cytotoxicities of the compounds and crude extract, against cultures of human melanoma cells (A375), were then investigated, and cytotoxicity/antimalarial IC(50) ratios of 0.6-16.75 were recorded.
    CONCLUSIONS:
    In tests involving aortic rings from guinea pigs, a crude extract of the leaves of A. monticola was found to induce concentration-dependent vasorelaxation, causing up to 82% and 42% inhibition of noradrenaline- and KCl-induced contractions, respectively. The corresponding values for compounds 2 and 6 when tested against noradrenaline-induced contractions were approximately 18% and 35%, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.81 mL 9.0498 mL 18.0995 mL 36.1991 mL 45.2489 mL
    5 mM 0.362 mL 1.81 mL 3.6199 mL 7.2398 mL 9.0498 mL
    10 mM 0.181 mL 0.905 mL 1.81 mL 3.6199 mL 4.5249 mL
    50 mM 0.0362 mL 0.181 mL 0.362 mL 0.724 mL 0.905 mL
    100 mM 0.0181 mL 0.0905 mL 0.181 mL 0.362 mL 0.4525 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7''-O-甲氧基金松双黄酮; 7''-O-Methylsciadopitysin CFN96118 3778-25-4 C34H26O10 = 594.6 5mg QQ客服:3257982914
    台湾高黄酮 A; Taiwanhomoflavone A CFN96541 265120-00-1 C33H24O10 = 580.55 5mg QQ客服:3257982914
    3,8''-联芹菜甙元; 3,8'-Biapigenin CFN99025 101140-06-1 C30H18O10 = 538.5 5mg QQ客服:2056216494
    GB 1a; GB 1a CFN96934 220611-41-6 C30H22O10 = 542.49 5mg QQ客服:1413575084
    GB 1b; GB 1b CFN89091 19360-72-6 C30H22O10 = 542.49 5mg QQ客服:1413575084
    GB 2a; GB 2a CFN89133 18412-96-9 C30H22O11 = 558.49 5mg QQ客服:2056216494
    荛花醇A; Wikstrol A CFN92960 159736-35-3 C30H22O10 = 542.49 5mg QQ客服:2056216494
    柏木双黄酮; Cupressuflavone CFN70356 3952-18-9 C30H18O10 = 538.5 5mg QQ客服:215959384
    4',4'''-双-O-甲基姜黄素; 4',4'''-Di-O-methylcupressuflavone CFN97224 74336-91-7 C32H22O10 = 566.5 5mg QQ客服:1413575084
    8,8''-二黄芩素; 8,8''-Bibaicalein CFN95007 135309-02-3 C30H18O10 = 538.5 5mg QQ客服:3257982914

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