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  • 苏铁双黄酮

    Sotetsuflavone

    苏铁双黄酮
    产品编号 CFN93257
    CAS编号 2608-21-1
    分子式 = 分子量 C31H20O10 = 552.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Selaginella tamariscina
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苏铁双黄酮 CFN93257 2608-21-1 1mg QQ客服:3257982914
    苏铁双黄酮 CFN93257 2608-21-1 5mg QQ客服:3257982914
    苏铁双黄酮 CFN93257 2608-21-1 10mg QQ客服:3257982914
    苏铁双黄酮 CFN93257 2608-21-1 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Hull (United Kingdom)
  • Griffith University (Australia)
  • University of Maryland (USA)
  • Universite de Lille1 (France)
  • University of Melbourne (Australia)
  • Universit?t Basel (Switzerland)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University of Lodz (Poland)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • University of Indonesia (Indonesia)
  • University of Hawaii Cancer Center (USA)
  • Univerzita Karlova v Praze (Czech Republic)
  • Sapienza University of Rome (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plos One.2020, 10.1371
  • Molecules2022, 27(12):3903.
  • University of Central Lancashire2017, 20472
  • Korean j.of Pharm.2017, 70-76
  • J Adv Res.2021, 35:245-257.
  • Molecules.2021, 26(18):5665.
  • J. Food Composition and Anal.2022, V 109:104482.
  • Processes2021, 9(1), 153;
  • TCI CO.2019, US20190151257A1
  • Appl. Sci.2020, 10,1304
  • Int J Biol Macromol.2021, 199:189-200.
  • Nat Plants.2016, 3:16205
  • J Food Biochem.2020, 44(6):e13198.
  • Molecules.2016, 21(10)
  • J of Essential Oil Research2019, 1677272
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Neurochem Int.2020, 133:104629
  • Molecules.2020, 25(21):5091.
  • J Ethnopharmacol.2022, 291:115159.
  • Molecules.2020, 25(9):2111.
  • Neurotox Res.2020, 38(1):163-174.
  • J Biochem Mol Toxicol.2021, 35(5):e22731.
  • ...
  • 生物活性
    Description: Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 uM, is the most active compound of this series.
    Targets: DENV-NS5 RdRp
    In vitro:
    Planta Med. 2013 Sep;79(14):1313-8.
    Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.[Pubmed: 23929244 ]
    Dengue virus is the world's most prevalent human pathogenic arbovirus. There is currently no treatment or vaccine, and solutions are urgently needed. We previously demonstrated that biflavonoids from Dacrydium balansae, an endemic gymnosperm from New Caledonia, are potent inhibitors of the Dengue virus NS5 RNA-dependent RNA polymerase.
    METHODS AND RESULTS:
    Herein we describe the structure-activity relationship study of 23 compounds: biflavonoids from D. balansae (1-4) and from D. araucarioides (5-10), hexamethyl-amentoflavone (11), cupressuflavone (12), and apigenin derivatives (13-23). We conclude that 1) over the four different biflavonoid skeletons tested, amentoflavone (1) and robustaflavone (5) are the most promising ones for antidengue drug development, 2) the number and position of methyl groups on the biflavonoid moiety modulate their inhibition of Dengue virus NS5 RNA-dependent RNA polymerase, and 3) the degree of oxygenation of flavonoid monomers influences their antidengue potential.
    CONCLUSIONS:
    Sotetsuflavone (8), with an IC50 = 0.16 μM, is the most active compound of this series and is the strongest inhibitor of the Dengue virus NS5 RNA-dependent RNA polymerase described in the literature.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.81 mL 9.0498 mL 18.0995 mL 36.1991 mL 45.2489 mL
    5 mM 0.362 mL 1.81 mL 3.6199 mL 7.2398 mL 9.0498 mL
    10 mM 0.181 mL 0.905 mL 1.81 mL 3.6199 mL 4.5249 mL
    50 mM 0.0362 mL 0.181 mL 0.362 mL 0.724 mL 0.905 mL
    100 mM 0.0181 mL 0.0905 mL 0.181 mL 0.362 mL 0.4525 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-去甲基银杏双黄酮; Bilobetin CFN98846 521-32-4 C31H20O10 = 552.5 20mg QQ客服:3257982914
    苏铁双黄酮; Sotetsuflavone CFN93257 2608-21-1 C31H20O10 = 552.5 5mg QQ客服:215959384
    银杏素; Ginkgetin CFN90173 481-46-9 C32H22O10 = 566.51 20mg QQ客服:1413575084
    罗汉松黄酮A; Podocarpusflavone A CFN98202 22136-74-9 C31H20O10 = 552.5 5mg QQ客服:1457312923
    竹柏双黄酮B; Putraflavone CFN98246 23624-21-7 C32H22O10 = 566.5 5mg QQ客服:3257982914
    三叶橡胶黄酮; Heveaflavone CFN98236 23132-13-0 C33H24O10 = 580.6 5mg QQ客服:2159513211
    异银杏双黄酮; Isoginkgetin CFN90174 548-19-6 C32H22O10 = 566.51 20mg QQ客服:215959384
    金松双黄酮; Sciadopitysin CFN98847 521-34-6 C33H24O10 = 580.6 20mg QQ客服:215959384
    7''-O-甲氧基金松双黄酮; 7''-O-Methylsciadopitysin CFN96118 3778-25-4 C34H26O10 = 594.6 5mg QQ客服:3257982914
    台湾高黄酮 A; Taiwanhomoflavone A CFN96541 265120-00-1 C33H24O10 = 580.55 5mg QQ客服:2159513211

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