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  • 银杏素

    Ginkgetin

    银杏素
    产品编号 CFN90173
    CAS编号 481-46-9
    分子式 = 分子量 C32H22O10 = 566.51
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Ginkgo biloba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    银杏素 CFN90173 481-46-9 10mg QQ客服:1413575084
    银杏素 CFN90173 481-46-9 20mg QQ客服:1413575084
    银杏素 CFN90173 481-46-9 50mg QQ客服:1413575084
    银杏素 CFN90173 481-46-9 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Julius Kühn-Institut (Germany)
  • Calcutta University (India)
  • Chiang Mai University (Thailand)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Kyung Hee University (Korea)
  • Imperial College London (United Kingdom)
  • Semmelweis Unicersity (Hungary)
  • University of Leipzig (Germany)
  • St. Jude Children Research Hospital (USA)
  • Heidelberg University (Germany)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Kazusa DNA Research Institute (Japan)
  • Siksha O Anusandhan University (India)
  • University of Otago (New Zealand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2021, 16(9):e0257243.
  • Chem Biol Interact.2019, 315:108910
  • Eur J Pharmacol.2018, 832:96-103
  • iScience.2020, 23(2):100849.
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Food Res Int.2020, 128:108778
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Eur J Neurosci.2021, 53(11):3548-3560.
  • Ind Crops Prod.2014, 62:173-178
  • Srinagarind Medical Journal2017, 32(1)
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Toxins (Basel).2021, 13(12):898.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Bulletin of Health Research2016, 44(4):279-286
  • Int Immunopharmacol.2019, 71:361-371
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • University of Central Lancashire2017, 20472
  • Sci Adv.2018, 4(10)
  • Phytochem Anal.2016, 27(5):296-303
  • Plants (Basel).2020, 9(11):1535.
  • J Pharm Biomed Anal.2018, 151:32-41
  • Braz J Med Biol Res. 2016, 49(7)
  • ...
  • 生物活性
    Description: Ginkgetin is a good STAT3 inhibitor , which has anti-inflammatory, neuroprotective, anti-influenza virus and anti-fungal activities. Ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment.
    Targets: Bcl-2/Bax | Caspase | STAT | COX | PGE | PRAP | Bcl-xL | Antifection
    In vitro:
    Bioorg Med Chem Lett. 2013 May 1;23(9):2692-5.
    Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells.[Pubmed: 23523142]
    Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L. Though it was known to have anti-inflammatory, anti-influenza virus, anti-fungal activity, osteoblast differentiation stimulating activity and neuro-protective effects, the underlying antitumor mechanism of ginkgetin still remains unclear. Thus, in the present study, anti-cancer mechanism of ginkgetin was elucidated in human prostate cancer PC-3 cells.
    METHODS AND RESULTS:
    Ginkgetin suppressed the viability of PC-3 cells in a concentration-dependent manner and also significantly increased the sub-G1 DNA contents of cell cycle in PC-3 cells. Ginkgetin activated caspase-3 and attenuated the expression of survival genes such as Bcl-2, Bcl-xL, survivin and Cyclin D1 at protein and mRNA levels. Consistently, pan-caspase inhibitor Z-DEVD-fmk blocked sub G1 accumulation and cleavages of PRAP and caspase 3 induced by ginkgetin in PC-3 cells.
    CONCLUSIONS:
    Overall, these findings suggest that ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment.
    In vivo:
    Free Radic Res. 2015 May 12:1-39.
    Neuroprotective effects of ginkgetin against neuro-injury in Parkinson's disease model induced by MPTP via chelating iron.[Pubmed: 25968939]
    Disruption of neuronal iron homeostasis and oxidative stress are closely related to the pathogenesis of Parkinson's disease (PD). Ginkgetin, a natural biflavonoid isolated from leaves of Ginkgo biloba L, has many known effects, including anti-inflammatory, anti-influenza virus, and anti-fungal activities, but its underlying mechanism of the neuroprotective effects in PD remains unclear.
    METHODS AND RESULTS:
    The present study utilized PD models induced by 1-methyl-4-phenylpyridinium (MPP(+)) and 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) to explore the neuroprotective ability of ginkgetin in vivo and in vitro. Our results showed that ginkgetin could provide significant protection from MPP(+)-induced cell damage in vitro by decreasing the levels of intracellular reactive oxygen species and maintaining mitochondrial membrane potential. Meanwhile, ginkgetin dramatically inhibited cell apoptosis induced by MPP+ through the caspase-3 and Bcl2/Bax pathway. Moreover, ginkgetin significantly improved sensorimotor coordination in a mouse PD model induced by MPTP by dramatically inhibiting the decrease of tyrosine hydroxylase expression in the substantia nigra and superoxide dismutase activity in the striatum. Interestingly, ginkgetin could strongly chelate ferrous ion and thereby inhibit the increase of the intracellular labile iron pool through downregulating L-ferritin and upregulating transferrin receptor 1.
    CONCLUSIONS:
    These results indicate that the neuroprotective mechanism of ginkgetin against neurological injury induced by MPTP occurs via regulating iron homeostasis. Therefore, ginkgetin may provide neuroprotective therapy for PD and iron metabolism disorder related diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7652 mL 8.826 mL 17.6519 mL 35.3039 mL 44.1298 mL
    5 mM 0.353 mL 1.7652 mL 3.5304 mL 7.0608 mL 8.826 mL
    10 mM 0.1765 mL 0.8826 mL 1.7652 mL 3.5304 mL 4.413 mL
    50 mM 0.0353 mL 0.1765 mL 0.353 mL 0.7061 mL 0.8826 mL
    100 mM 0.0177 mL 0.0883 mL 0.1765 mL 0.353 mL 0.4413 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2,3-Dihydroamentoflavone 7,4'-dimethyl ether; 2,3-Dihydroamentoflavone 7,4'-dimethyl ether CFN96163 873999-88-3 C32H24O10 = 568.5 5mg QQ客服:2159513211
    2,3-二羟基三叶橡胶黄酮; 2,3-Dihydroheveaflavone CFN96119 110382-42-8 C33H26O10 = 582.6 5mg QQ客服:1413575084
    2,3-二羟基金松双黄酮; 2,3-dihydrosciadopitysin CFN96134 34421-19-7 C33H26O10 = 582.6 5mg QQ客服:2056216494
    2,3-二氢罗汉松黄酮A; 2,3-Dihydropodocarpusflavone A CFN96378 852875-96-8 C31H22O10 = 554.5 5mg QQ客服:215959384
    四氢阿曼托黄素; Tetrahydroamentoflavone CFN98755 48236-96-0 C30H22O10 = 542.5 5mg QQ客服:2056216494
    穗花杉双黄酮; 阿曼托黄酮; Amentoflavone CFN99526 1617-53-4 C30H18O10 = 538.46 20mg QQ客服:1413575084
    7-去甲基银杏双黄酮; Bilobetin CFN98846 521-32-4 C31H20O10 = 552.5 20mg QQ客服:3257982914
    苏铁双黄酮; Sotetsuflavone CFN93257 2608-21-1 C31H20O10 = 552.5 5mg QQ客服:1457312923
    银杏素; Ginkgetin CFN90173 481-46-9 C32H22O10 = 566.51 20mg QQ客服:2159513211
    罗汉松黄酮A; Podocarpusflavone A CFN98202 22136-74-9 C31H20O10 = 552.5 5mg QQ客服:2056216494

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