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  • 7-去甲基银杏双黄酮

    • 7-去甲基银杏双黄酮

    Bilobetin

    7-去甲基银杏双黄酮
    		产品编号 CFN98846
    CAS编号 521-32-4
    分子式 = 分子量 C31H20O10 = 552.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Ginkgo biloba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7-去甲基银杏双黄酮 CFN98846 521-32-4 10mg QQ客服：3257982914
    7-去甲基银杏双黄酮 CFN98846 521-32-4 20mg QQ客服：3257982914
    7-去甲基银杏双黄酮 CFN98846 521-32-4 50mg QQ客服：3257982914
    7-去甲基银杏双黄酮 CFN98846 521-32-4 100mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Nat Med.2020, 74(3):550-560.
  • Sci Rep. 2018, 1-9
  • Phytomedicine.2022, 96:153877.
  • VNU Journal of Science2023, No. 20.
  • Int J Mol Sci.2022, 23(21):13112.
  • GxABT2022, 2268.2:15515.
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • Elife.2021, 10:e68058.
  • Drug Chem Toxicol.2020, 1-14.
  • Int Immunopharmacol. 2020, 83:106403.
  • J Pharmaceut Biomed2020, 178:112894
  • ACS Omega.2022, 7(44):40009-40020.
  • Front Pharmacol.2021, 12:762829.
  • Phytother Res.2015, 29(7):1088-96
  • Int Immunopharmacol.2020, 90:107268.
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Biosci Rep.2020, 40(8):BSR20201219.
  • Food Science and Biotechnology2023, 2023:1007
  • Synthetic and Systems Biotechnology2023, j.synbio.
  • Agronomy2020, 10(3),388.
  • Oncotarget.2017, 8(64):108006-108019
  • The Journal of Phytopharmacology2020, 9(1): 1-4
  • ...
    • 生物活性
    Description: Bilobetin treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPARα-mediated lipid catabolism.
    Targets: PPAR | cAMP
    In vivo:
    Br J Pharmacol. 2012 Apr;165(8):2692-706.
    Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.[Pubmed: 22091731]
    The amelioration of insulin resistance by bilobetin is closely related to its hypolipidaemic effect. The aim of the present study was to determine the insulin-sensitizing mechanism of bilobetin by elucidating its effect on lipid metabolism.
    METHODS AND RESULTS:
    Rats fed a high-fat diet were treated with bilobetin for either 4 or 14 days before applying a hyperinsulinaemic-euglycaemic clamp. Triglyceride and fatty acids labelled with radioactive isotopes were used to track the transportation and the fate of lipids in tissues. The activity of lipid metabolism-related enzymes and β-oxidation rate were measured. Western blot was used to investigate the phosphorylation, translocation and expression of PPARα in several tissues and cultured cells. The location of amino acid residues subjected to phosphorylation in PPARα was also studied. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity. Threonine-129-alanine and/or serine-163-alanine mutations on the PPARα genes and PKA inhibitors prevented the effects of bilobetin on PPARα. However, cells overexpressing PKA appeared to stimulate the phosphorylation, nuclear translocation and activity of PPARα.
    CONCLUSIONS:
    Bilobetin treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPARα-mediated lipid catabolism. PKA activation is crucial for this process.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.81 mL 9.0498 mL 18.0995 mL 36.1991 mL 45.2489 mL
    5 mM 0.362 mL 1.81 mL 3.6199 mL 7.2398 mL 9.0498 mL
    10 mM 0.181 mL 0.905 mL 1.81 mL 3.6199 mL 4.5249 mL
    50 mM 0.0362 mL 0.181 mL 0.362 mL 0.724 mL 0.905 mL
    100 mM 0.0181 mL 0.0905 mL 0.181 mL 0.362 mL 0.4525 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4',4'''-双-O-甲基姜黄素; 4',4'''-Di-O-methylcupressuflavone CFN97224 74336-91-7 C32H22O10 = 566.5 5mg QQ客服：1413575084
    8,8''-二黄芩素; 8,8''-Bibaicalein CFN95007 135309-02-3 C30H18O10 = 538.5 5mg QQ客服：215959384
    Acuminatanol; Acuminatanol CFN96555 948884-38-6 C30H22O16 = 638.49 5mg QQ客服：2159513211
    2,3-Dihydroamentoflavone 7,4'-dimethyl ether; 2,3-Dihydroamentoflavone 7,4'-dimethyl ether CFN96163 873999-88-3 C32H24O10 = 568.5 5mg QQ客服：215959384
    2,3-二羟基三叶橡胶黄酮; 2,3-Dihydroheveaflavone CFN96119 110382-42-8 C33H26O10 = 582.6 5mg QQ客服：1413575084
    2,3-二羟基金松双黄酮; 2,3-dihydrosciadopitysin CFN96134 34421-19-7 C33H26O10 = 582.6 5mg QQ客服：1413575084
    2,3-二氢罗汉松黄酮A; 2,3-Dihydropodocarpusflavone A CFN96378 852875-96-8 C31H22O10 = 554.5 5mg QQ客服：1457312923
    四氢阿曼托黄素; Tetrahydroamentoflavone CFN98755 48236-96-0 C30H22O10 = 542.5 5mg QQ客服：215959384
    3',3'''-二柚皮素; 3',3'''-Binaringenin CFN95558 145399-99-1 C30H22O10 = 542.5 5mg QQ客服：215959384
    穗花杉双黄酮； 阿曼托黄酮; Amentoflavone CFN99526 1617-53-4 C30H18O10 = 538.46 20mg QQ客服：1413575084

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