7-去甲基银杏双黄酮

Bilobetin

	产品编号	CFN98846
	CAS编号	521-32-4
	分子式 = 分子量	C₃₁H₂₀O₁₀ = 552.5
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The leaves of Ginkgo biloba L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
7-去甲基银杏双黄酮	CFN98846	521-32-4	10mg	QQ客服：215959384
7-去甲基银杏双黄酮	CFN98846	521-32-4	20mg	QQ客服：215959384
7-去甲基银杏双黄酮	CFN98846	521-32-4	50mg	QQ客服：215959384
7-去甲基银杏双黄酮	CFN98846	521-32-4	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Chinese University of Hong Kong (China)

Copenhagen University (Denmark)

Sanford Burnham Prebys Medical Discovery Institute (USA)

Lodz University of Technology (Poland)

Srinakharinwirot University (Thailand)

Almansora University (Egypt)

Auburn University (USA)

Sapienza University of Rome (Italy)

Sri Ramachandra University (India)

Johannes Gutenberg University Mainz (JGU) (Germany)

The Ohio State University (USA)

University of Padjajaran (Indonesia)

Osmania University (India)

Kamphaengphet Rajabhat University (Thailand)

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Description:

Bilobetin treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPARα-mediated lipid catabolism.

Targets:

PPAR | cAMP

In vivo:

Br J Pharmacol. 2012 Apr;165(8):2692-706.

Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.[Pubmed: 22091731]

The amelioration of insulin resistance by bilobetin is closely related to its hypolipidaemic effect. The aim of the present study was to determine the insulin-sensitizing mechanism of bilobetin by elucidating its effect on lipid metabolism.
METHODS AND RESULTS:
Rats fed a high-fat diet were treated with bilobetin for either 4 or 14 days before applying a hyperinsulinaemic-euglycaemic clamp. Triglyceride and fatty acids labelled with radioactive isotopes were used to track the transportation and the fate of lipids in tissues. The activity of lipid metabolism-related enzymes and β-oxidation rate were measured. Western blot was used to investigate the phosphorylation, translocation and expression of PPARα in several tissues and cultured cells. The location of amino acid residues subjected to phosphorylation in PPARα was also studied. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity. Threonine-129-alanine and/or serine-163-alanine mutations on the PPARα genes and PKA inhibitors prevented the effects of bilobetin on PPARα. However, cells overexpressing PKA appeared to stimulate the phosphorylation, nuclear translocation and activity of PPARα.
CONCLUSIONS:
Bilobetin treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPARα-mediated lipid catabolism. PKA activation is crucial for this process.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Acuminatanol; Acuminatanol	CFN96555	948884-38-6	C₃₀H₂₂O₁₆ = 638.49	5mg	QQ客服：1457312923
Isoacuminatanol; Isoacuminatanol	CFN95766	2446349-77-3	C₃₀H₂₂O₁₆ = 638.5	5mg	QQ客服：3257982914
2,3-Dihydroamentoflavone 7,4'-dimethyl ether; 2,3-Dihydroamentoflavone 7,4'-dimethyl ether	CFN96163	873999-88-3	C₃₂H₂₄O₁₀ = 568.5	5mg	QQ客服：1457312923
2,3-二羟基三叶橡胶黄酮; 2,3-Dihydroheveaflavone	CFN96119	110382-42-8	C₃₃H₂₆O₁₀ = 582.6	5mg	QQ客服：215959384
2,3-二羟基金松双黄酮; 2,3-dihydrosciadopitysin	CFN96134	34421-19-7	C₃₃H₂₆O₁₀ = 582.6	5mg	QQ客服：2159513211
2,3-二氢罗汉松黄酮A; 2,3-Dihydropodocarpusflavone A	CFN96378	852875-96-8	C₃₁H₂₂O₁₀ = 554.5	5mg	QQ客服：1457312923
四氢阿曼托黄素; Tetrahydroamentoflavone	CFN98755	48236-96-0	C₃₀H₂₂O₁₀ = 542.5	5mg	QQ客服：2159513211
3',3'''-二柚皮素; 3',3'''-Binaringenin	CFN95558	145399-99-1	C₃₀H₂₂O₁₀ = 542.5	5mg	QQ客服：1457312923
穗花杉双黄酮；阿曼托黄酮; Amentoflavone	CFN99526	1617-53-4	C₃₀H₁₈O₁₀ = 538.46	20mg	QQ客服：1457312923
7-去甲基银杏双黄酮; Bilobetin	CFN98846	521-32-4	C₃₁H₂₀O₁₀ = 552.5	20mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.81 mL	9.0498 mL	18.0995 mL	36.1991 mL	45.2489 mL
5 mM	0.362 mL	1.81 mL	3.6199 mL	7.2398 mL	9.0498 mL
10 mM	0.181 mL	0.905 mL	1.81 mL	3.6199 mL	4.5249 mL
50 mM	0.0362 mL	0.181 mL	0.362 mL	0.724 mL	0.905 mL
100 mM	0.0181 mL	0.0905 mL	0.181 mL	0.362 mL	0.4525 mL