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  • 四氢阿曼托黄素

    Tetrahydroamentoflavone

    四氢阿曼托黄素
    产品编号 CFN98755
    CAS编号 48236-96-0
    分子式 = 分子量 C30H22O10 = 542.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Selaginella uncinata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    四氢阿曼托黄素 CFN98755 48236-96-0 1mg QQ客服:2056216494
    四氢阿曼托黄素 CFN98755 48236-96-0 5mg QQ客服:2056216494
    四氢阿曼托黄素 CFN98755 48236-96-0 10mg QQ客服:2056216494
    四氢阿曼托黄素 CFN98755 48236-96-0 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Helmholtz Zentrum München (Germany)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Toulouse (France)
  • University of Bordeaux (France)
  • University of Eastern Finland (Finland)
  • Charles University in Prague (Czech Republic)
  • University of Bonn (Germany)
  • Shanghai University of TCM (China)
  • Tohoku University (Japan)
  • Seoul National University (Korea)
  • University of Hawaii Cancer Center (USA)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Rio de Janeiro State University (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2022, 99:154025.
  • Pharmacogn Mag.2015, 11(43):562-6
  • Int J Mol Sci.2017, 18(5)
  • Universitat Stuttgart2022, opus-12200.
  • Int J Mol Sci.2021, 22(17):9400.
  • HortTechnology2016, 26(6):816-819
  • Int J Mol Med.2020, 45(5):1514-1524.
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Int J Mol Sci.2020, 21(8):2790.
  • Molecules2022, 27(14):4601
  • Antioxidants (Basel).2020, 9(7):581.
  • Pak J Pharm Sci.2018, 31:311-315
  • J Nat Med.2018, 72(3):734-744
  • J of Applied Biological Chem.2020, 63(2):147-152
  • Cell.2018, 172(1-2):249-261
  • Front Microbiol.2021, 12:736780.
  • Journal of Apicultural Research2021, 60(1)
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Processes2021, 9(1), 153.
  • Iranian J. Pharm. Res.2021, 20(4):59-70
  • Separations2021, 8(6),80.
  • VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
  • Plant Sci.2021, 313:111069.
  • ...
  • 生物活性
    Description: Tetrahydroamentoflavone is a potent XO inhibitor, may be considered as a drug candidate or chemopreventive agent; it has anti-inflammatory effects, it shows in vitro cyclooxygenase (COX) inhibition activity ( an IC(50) value of 29.5 microM (COX-1) and 40.5% inhibition at 100 microg/mL (COX-2)). (2S,2″S )-Tetrahydroamentoflavone exerts its antioxidant activity in vitro through metal-chelating, and radical-scavenging, which is via donating a hydrogen atom (H61) and an electron (e).
    Targets: COX | Xanthine oxidase
    In vitro:
    J Ethnopharmacol. 2011 Feb 16;133(3):1117-20.
    Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase.[Pubmed: 20965242]
    Seed of Semecarpus anacardium L. is widely used in Indian traditional medicine; Ayurveda and Sidha, for treatment of inflammatory disorders and gout. The present study was aimed at isolation of a compound for its potential to inhibit xanthine oxidase (XO), over expression of which lead to inflammation and gout.
    METHODS AND RESULTS:
    Activity guided fractionation of S. anacardium seed was conducted using liquid-liquid partition and preparative HPLC. The fractions were evaluated for their XO inhibition and antioxidant activity. The ethyl acetate fraction with the highest XO activity yielded a biflavonoid compound tetrahydroamentoflavone (THA). Lineweaver-Burk (LB) plot for the XO inhibition of THA and allopurinol was constructed from the kinetic data. IC₅₀ values of THA and allopurinol for XO inhibition were 92 and 100 nM respectively and their corresponding values for K(i) were 0.982 and 0.612 μM respectively.
    CONCLUSIONS:
    THA was a potent XO inhibitor which could be considered as a drug candidate or chemopreventive agent, after establishing its pharmacological and clinical evaluation. The study results appear to support the claim of the traditional medicine with respect to the efficacy of S. anacardium seed against inflammation and gout.
    Natural Product Communications, 2013 ,8 (6) :787-9.
    Antioxidant Activity and Mechanism of Tetrahydroamentoflavone in vitro[Reference: WebLink]
    (2S,2″S )-Tetrahydroamentoflavone (THA) is a typical biflavonoid.
    METHODS AND RESULTS:
    In this study, we systematically evaluated its antioxidant activity by various antioxidant assays in vitro. The IC50 values of THA were 4.8±0.3, 743.2±49.5, 35.5±1.9, 165.7±22.8, 4.4±0.2, and 77.1±2.2 μg/mL, respectively, for superoxide (61O2-) radical-scavenging, Fe2+-chelating, Cu2+-chelating, DPPH61 (1,1-diphenyl-2-picrylhydrazyl radical) scavenging, ABTS61+ (3-ethylbenzthiazoline-6-sulfonic acid radical) scavenging, and Cu2+-reducing power. The average ratio value of IC50,Trolox:IC50,THA was calculated as 2.54, suggesting that THA possesses 2.54 times the total antioxidant level than the standard antioxidant Trolox.
    CONCLUSIONS:
    THA exerts its antioxidant activity in vitro through metal-chelating, and radical-scavenging, which is via donating a hydrogen atom (H61) and an electron (e). Its antioxidant activity can be responsible for its pharmacological effect and make it an attractive natural antioxidant.
    J Ethnopharmacol. 2004 Dec;95(2-3):209-12.
    A cyclooxygenase (COX) inhibitory biflavonoid from the seeds of Semecarpus anacardium.[Pubmed: 15507338 ]
    Semecarpus anacardium Linn., Anacardiaceae, is being most commonly used in India for the treatment of rheumatoid arthritis and other inflammatory disorders.
    METHODS AND RESULTS:
    Bioactivity guided fractionation of ethyl acetate extract led to the isolation of major active principle, Tetrahydroamentoflavone (THA), a biflavonoid. The in vitro cyclooxygenase (COX-1) catalyzed prostaglandin biosynthesis assay of THA gave an IC(50) value of 29.5 microM (COX-1) and 40.5% inhibition at 100 microg/mL (COX-2). The in vivo carrageenan induced paw edema assay resulted in dose dependent anti-inflammatory effect of THA and the activity was comparable to that of ibuprofen, one of the well known NSAIDs.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8433 mL 9.2166 mL 18.4332 mL 36.8664 mL 46.0829 mL
    5 mM 0.3687 mL 1.8433 mL 3.6866 mL 7.3733 mL 9.2166 mL
    10 mM 0.1843 mL 0.9217 mL 1.8433 mL 3.6866 mL 4.6083 mL
    50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.7373 mL 0.9217 mL
    100 mM 0.0184 mL 0.0922 mL 0.1843 mL 0.3687 mL 0.4608 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2,3-二羟基金松双黄酮; 2,3-dihydrosciadopitysin CFN96134 34421-19-7 C33H26O10 = 582.6 5mg QQ客服:215959384
    2,3-二氢罗汉松黄酮A; 2,3-Dihydropodocarpusflavone A CFN96378 852875-96-8 C31H22O10 = 554.5 5mg QQ客服:215959384
    四氢阿曼托黄素; Tetrahydroamentoflavone CFN98755 48236-96-0 C30H22O10 = 542.5 5mg QQ客服:2159513211
    穗花杉双黄酮; 阿曼托黄酮; Amentoflavone CFN99526 1617-53-4 C30H18O10 = 538.46 20mg QQ客服:2056216494
    7-去甲基银杏双黄酮; Bilobetin CFN98846 521-32-4 C31H20O10 = 552.5 20mg QQ客服:1413575084
    苏铁双黄酮; Sotetsuflavone CFN93257 2608-21-1 C31H20O10 = 552.5 5mg QQ客服:3257982914
    银杏素; Ginkgetin CFN90173 481-46-9 C32H22O10 = 566.51 20mg QQ客服:1457312923
    罗汉松黄酮A; Podocarpusflavone A CFN98202 22136-74-9 C31H20O10 = 552.5 5mg QQ客服:1457312923
    竹柏双黄酮B; Putraflavone CFN98246 23624-21-7 C32H22O10 = 566.5 5mg QQ客服:2159513211
    三叶橡胶黄酮; Heveaflavone CFN98236 23132-13-0 C33H24O10 = 580.6 5mg QQ客服:2056216494

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