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  • 2,3-二羟基金松双黄酮

    2,3-dihydrosciadopitysin

    2,3-二羟基金松双黄酮
    产品编号 CFN96134
    CAS编号 34421-19-7
    分子式 = 分子量 C33H26O10 = 582.6
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The hertwoods of Podocarpus macrophyllus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2,3-二羟基金松双黄酮 CFN96134 34421-19-7 1mg QQ客服:1413575084
    2,3-二羟基金松双黄酮 CFN96134 34421-19-7 5mg QQ客服:1413575084
    2,3-二羟基金松双黄酮 CFN96134 34421-19-7 10mg QQ客服:1413575084
    2,3-二羟基金松双黄酮 CFN96134 34421-19-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • St. Jude Children Research Hospital (USA)
  • Chinese University of Hong Kong (China)
  • Universidad de Antioquia (Colombia)
  • Chiang Mai University (Thailand)
  • University of Wisconsin-Madison (USA)
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  • Lodz University of Technology (Poland)
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  • Colorado State University (USA)
  • Universidad de La Salle (Mexico)
  • University Medical Center Mainz (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Ginseng Research2021, 3 June.
  • Wageningen University & Research2018, January 2018
  • SBRAS2016, 12
  • PLoS One.2021, 16(9):e0257243.
  • Food Chem.2018, 262:78-85
  • Eur J Pharmacol.2020, 889:173589.
  • Inflammation.2015, 38(4):1502-16
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • Sci Rep. 2018, 1-9
  • ACS Chem Biol.2019, 14(5):873-881
  • Pharmaceuticals (Basel).2021, 14(6):588.
  • Nat Plants.2016, 3:16205
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Journal of Functional Foods2022, 91:105019.
  • Molecules.2019, 24(9):E1719
  • Nanjing University of Chinese Medicine2022, 345930.
  • Curr Eye Res.2018, 43(1):27-34
  • Journal of Life Science2017, 233-240
  • Pharmacognosy Journal2019, 11(2): 369-373
  • J Pharmacol Sci.2021, 147(2):184-191.
  • Applied Biological Chemistry2020, 63:33(2020)
  • Nat Chem Biol.2018, 14(8):760-763
  • PLoS One.2022, 17(6):e0268505.
  • ...
  • 生物活性
    Description: Standard reference
    In vitro:
    Chem Pharm Bull (Tokyo). 2007 May;55(5):757-61.
    New constituent from Podocarpus macrophyllus var. macrophyllus shows anti-tyrosinase effect and regulates tyrosinase-related proteins and mRNA in human epidermal melanocytes.[Pubmed: 17473463]
    A new biflavonoid, 2,3-dihydro-4',4'''-di-O-methylamentoflavone (5), and five known compounds, (-)-catechin (1), quercetin (2), 2,3-dihydrosciadopitysin (3), sciadopitysin (4), and isoginkgetin (6), were isolated from Podocarpus macrophyllus var. macrophyllus (Podocarpaceae). These compounds were evaluated their ability to inhibit cellular tyrosinase activity and for their melanin inhibitory activity in human epidermal melanocytes (HEMn).
    METHODS AND RESULTS:
    In the melanin synthesis assay, 2,3-dihydro-4',4'''-di-O-methylamentoflavone (5) showed a potent anti-tyrosinase effect with IC(50)=0.098 mM in HEMn. It also significantly decreased both protein and mRNA levels of the tyrosinase-related protein-2 (TRP-2) by Western blot and quantitative real-time PCR (qRT-PCR) analysis.
    CONCLUSIONS:
    These findings suggest that the new compound, 2,3-dihydro-4',4'''-di-O-methylamentoflavone (5), is the most active component of P. macrophyllus var. macrophyllus in inhibiting pigmentation and that this inhibition is exerted through inhibition of transcription of the genes encoding TRP2.
    Z Naturforsch C. 2003 Jan-Feb;58(1-2):65-9.
    Antifungal activity of biflavones from Taxus baccata and Ginkgo biloba.[Pubmed: 12622229]
    Bilobetin and 4'''-O-methylamentoflavone were isolated and identified in the needles of Taxus baccata, for the first time in this species.
    METHODS AND RESULTS:
    The antifungal activity of biflavones from T. baccata and Ginkgo biloba, namely amentoflavone, 7-O-methylamentoflavone, bilobetin, ginkgetin, sciadopitysin and 2,3-dihydrosciadopitysin towards the fungi Alternaria alternata, Fusarium culmorum, Cladosporium oxysporum was determined employing computer-aided image analysis couplet to a microscope.
    CONCLUSIONS:
    Bilobetin exhibited a significant antifungal activity with values of ED50 14, 11 and 17 microM respectively. This compound completely inhibited the growth of germinating tubes of Cladosporium oxysporum and Fusarium culmorum at a concentration 100 microM. Activity of ginkgetin and 7-O-methylamentoflavone towards Alternaria alternata was stronger than that of bilobetin. Moreover, slight structural changes in the cell wall of Alternaria alternata exposed to ginkgetin at concentration of 200 microM were observed.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7164 mL 8.5822 mL 17.1644 mL 34.3289 mL 42.9111 mL
    5 mM 0.3433 mL 1.7164 mL 3.4329 mL 6.8658 mL 8.5822 mL
    10 mM 0.1716 mL 0.8582 mL 1.7164 mL 3.4329 mL 4.2911 mL
    50 mM 0.0343 mL 0.1716 mL 0.3433 mL 0.6866 mL 0.8582 mL
    100 mM 0.0172 mL 0.0858 mL 0.1716 mL 0.3433 mL 0.4291 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-去甲基银杏双黄酮; Bilobetin CFN98846 521-32-4 C31H20O10 = 552.5 20mg QQ客服:1457312923
    苏铁双黄酮; Sotetsuflavone CFN93257 2608-21-1 C31H20O10 = 552.5 5mg QQ客服:2159513211
    银杏素; Ginkgetin CFN90173 481-46-9 C32H22O10 = 566.51 20mg QQ客服:3257982914
    罗汉松黄酮A; Podocarpusflavone A CFN98202 22136-74-9 C31H20O10 = 552.5 5mg QQ客服:2056216494
    竹柏双黄酮B; Putraflavone CFN98246 23624-21-7 C32H22O10 = 566.5 5mg QQ客服:1457312923
    三叶橡胶黄酮; Heveaflavone CFN98236 23132-13-0 C33H24O10 = 580.6 5mg QQ客服:2056216494
    异银杏双黄酮; Isoginkgetin CFN90174 548-19-6 C32H22O10 = 566.51 20mg QQ客服:1457312923
    金松双黄酮; Sciadopitysin CFN98847 521-34-6 C33H24O10 = 580.6 20mg QQ客服:3257982914
    7''-O-甲氧基金松双黄酮; 7''-O-Methylsciadopitysin CFN96118 3778-25-4 C34H26O10 = 594.6 5mg QQ客服:215959384
    台湾高黄酮 A; Taiwanhomoflavone A CFN96541 265120-00-1 C33H24O10 = 580.55 5mg QQ客服:3257982914

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