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  • 蜕皮激素

    Ecdysone

    蜕皮激素
    产品编号 CFN90487
    CAS编号 3604-87-3
    分子式 = 分子量 C27H44O6 = 464.63
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Steroids
    植物来源 The roots of Cyanotis arachnoidea C. B. Clarke
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蜕皮激素 CFN90487 3604-87-3 1mg QQ客服:215959384
    蜕皮激素 CFN90487 3604-87-3 5mg QQ客服:215959384
    蜕皮激素 CFN90487 3604-87-3 10mg QQ客服:215959384
    蜕皮激素 CFN90487 3604-87-3 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2019, 20(11):E2734
  • Front Immunol.2018, 9:2655
  • University of Stuttgart2021, 11682.
  • Planta Med.2018, 84(6-07):465-474
  • Cell Rep.2022, 39(1):110643.
  • Food Res Int.2018, 106:909-919
  • J Pharm Biomed Anal.2019, 164:119-127
  • Appl. Sci. 2021, 11(23),11099.
  • J Food Sci Technol.2022, 59(1):212-219.
  • BMC Complement Altern Med.2019, 19(1):367
  • Int J Mol Sci.2020, 21(6):2190.
  • Int. J. of Food Properties2017, S108-S118
  • Scientific World Journal.2014, 2014:654193
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • Natural Product Communications2021, 16(9):1-10.
  • J Pain Res.2022, 15:3469-3478.
  • Int J Mol Sci.2021, 22(21):11836.
  • Journal of Molecular Liquids2021, 334:116014.
  • Industrial Crops and Products2022, 188:115638
  • Cells.2022, 11(8), 1311.
  • J Nat Prod.2015, 78(6):1339-4
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • ...
  • 生物活性
    Description: Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D and activates the expression of BmBR-C. Mnoaminergic autocrine signaling in the PG regulates Ecdysone biogenesis in a coordinated fashion on activation by PTTH and Ilps.
    Targets: Sodium Channel | ATPase | Potassium Channel | Autophagy
    In vitro:
    Dev Biol. 2015 Feb 15;398(2):163-76.
    Ecdysone regulates morphogenesis and function of Malpighian tubules in Drosophila melanogaster through EcR-B2 isoform.[Pubmed: 25476260]
    Malpighian tubules are the osmoregulatory and detoxifying organs of Drosophila and its proper development is critical for the survival of the organism. They are made up of two major cell types, the ectodermal principal cells and mesodermal stellate cells. The principal and stellate cells are structurally and physiologically distinct from each other, but coordinate together for production of isotonic fluid. Proper integration of these cells during the course of development is an important pre-requisite for the proper functioning of the tubules.
    METHODS AND RESULTS:
    We have conclusively determined an essential role of ecdysone hormone in the development and function of Malpighian tubules. Disruption of ecdysone signaling interferes with the organization of principal and stellate cells resulting in malformed tubules and early larval lethality. Abnormalities include reduction in the number of cells and the clustering of cells rather than their arrangement in characteristic wild type pattern. Organization of F-actin and β-tubulin also show aberrant distribution pattern. Malformed tubules show reduced uric acid deposition and altered expression of Na(+)/K(+)-ATPase pump.
    CONCLUSIONS:
    B2 isoform of ecdysone receptor is critical for the development of Malpighian tubules and is expressed from early stages of its development.
    Insect Mol Biol. 2014 Jun;23(3):341-56.
    Ecdysone response elements in the distal promoter of the Bombyx Broad-Complex gene, BmBR-C.[Pubmed: 24576019]

    METHODS AND RESULTS:
    As determined by a luciferase assay, the transcriptional activity of Pdist, but not Pprox, was activated by Ecdysone. Further analyses using reporters driven by sequential deletion Pdist mutants indicated that two regions, Ecdysone responsive element (EcRE)-D and EcRE-P, -4950 bp and -3480 bp upstream from the distal transcription start site, respectively, were important in the responsiveness of Pdist to 20-hydroxyEcdysone (20E); however, no significant sequence similarities were found between the canonical EcRE and the EcRE-D or EcRE-P regions. Electrophoretic mobility shift assays showed that both the EcRE-D and -P sequences specifically bound to Bombyx protein(s). Sequence analyses and competition assays suggested that the protein(s) bound to EcRE-P might include components other than the Ecdysone receptor (EcR), suggesting that BmBR-C transcription was indirectly activated by Ecdysone through the EcRE-P. Remarkably, protein binding to the mid-region of the EcRE-D, EcRE-Db, was competitively inhibited by an oligonucleotide containing the Drosophila hsp27 EcRE sequence. Furthermore, an anti-EcR antibody interfered with the formation of the protein-EcRE-Db complex.
    CONCLUSIONS:
    These results indicated that a functional Bombyx Ecdysone receptor binds to EcRE-D and activates the expression of BmBR-C.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1523 mL 10.7613 mL 21.5225 mL 43.045 mL 53.8063 mL
    5 mM 0.4305 mL 2.1523 mL 4.3045 mL 8.609 mL 10.7613 mL
    10 mM 0.2152 mL 1.0761 mL 2.1523 mL 4.3045 mL 5.3806 mL
    50 mM 0.043 mL 0.2152 mL 0.4305 mL 0.8609 mL 1.0761 mL
    100 mM 0.0215 mL 0.1076 mL 0.2152 mL 0.4305 mL 0.5381 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蜕皮甾酮-20,22-单丙酮化物; Ecdysterone 20,22-monoacetonide CFN98229 22798-96-5 C30H48O7 = 520.7 5mg QQ客服:3257982914
    蜕皮甾酮2,3:20,22- 二缩丙酮; Ecdysterone 2,3:20,22-diacetonide CFN98230 22798-98-7 C33H52O7 = 560.8 5mg QQ客服:1413575084
    维生素D3; Vitamin D3 CFN90027 67-97-0 C27H44O = 384.64 20mg QQ客服:2056216494
    维生素D2; Ergocalciferol CFN90049 50-14-6 C28H44O = 396.65 20mg QQ客服:3257982914
    二氢胆固醇; Dihydrocholesterol CFN90608 80-97-7 C27H48O = 388.67 20mg QQ客服:1457312923
    胆固醇; 胆甾醇; Cholesterol CFN90040 57-88-5 C27H46O = 386.67 20mg QQ客服:1457312923
    4β-羟基胆固醇; 4-Beta-Hydroxycholesterol CFN90611 17320-10-4 C27H46O2 = 402.66 5mg QQ客服:2159513211
    7β-羟基胆固醇; 7Beta-Hydroxycholesterol CFN90610 566-27-8 C27H46O2 = 402.65 5mg QQ客服:1413575084
    7-酮基胆固醇; 7-Ketocholesterol CFN91812 566-28-9 C27H44O2 = 400.6 5mg QQ客服:3257982914
    7-氧胆固醇乙酯; 7-Oxocholesteryl acetate CFN91647 809-51-8 C29H46O3 = 442.7 5mg QQ客服:215959384

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