27-羟基胆固醇
27-Hydroxycholesterol
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 27-羟基胆固醇 |
CFN90609 |
20380-11-4 |
1mg |
QQ客服：215959384 |
| 27-羟基胆固醇 |
CFN90609 |
20380-11-4 |
5mg |
QQ客服：215959384 |
| 27-羟基胆固醇 |
CFN90609 |
20380-11-4 |
10mg |
QQ客服：215959384 |
| 27-羟基胆固醇 |
CFN90609 |
20380-11-4 |
20mg |
QQ客服：215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor, it may negatively modulate cognitive effects and cholesterol metabolism in the brain. 27-Hydroxycholesterol can enhance cell release of IL-8, IL-1β, and TNF-α and to upregulate matrix metalloproteinase-9 (MMP-9) via TLR4/NF-κB-dependent pathway; it also can reduce hepatic inflammation in hyperlipidemic mice. |
| Targets: |
Liver X Receptor | HMG-CoA Reductase | LDL | TLR | TNF-α | NF-kB | MMP(e.g.TIMP) | IL Receptor | P450 (e.g. CYP17) |
| In vivo: |
| Neuroscience. 2015 Aug 6;300:163-73. | | 27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain.[Pubmed: 25987203] | Cholesterol metabolism is important for neuronal function in the central nervous system (CNS). The oxysterol 27-Hydroxycholesterol (27-OHC) is a cholesterol metabolite that crosses the blood-brain barrier (BBB) and may be a useful substitutive marker for neurodegenerative diseases. However, the effects of 27-Hydroxycholesterol on learning and memory and the underlying mechanisms are unclear.
METHODS AND RESULTS:
To determine this mechanism, we investigated learning and memory and cholesterol metabolism in rat brain following the injection of various doses of 27-Hydroxycholesterol into the caudal vein. We found that 27-Hydroxycholesterol increased cholesterol levels and upregulated the expression of liver X receptor-α (LXR-α) and adenosine triphosphate (ATP)-binding cassette transporter protein family member A1 (ABCA1). In addition, 27-Hydroxycholesterol decreased the expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CR) and low-density lipoprotein receptor (LDLR) in rat brain tissues.
CONCLUSIONS:
These findings suggest that 27-Hydroxycholesterol may negatively modulate cognitive effects and cholesterol metabolism in the brain. | | Behav Brain Res. 2015 Feb 1;278:356-9. | | 27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice.[Pubmed: 25453744] | In spite of the fact that cholesterol does not pass the blood-brain barrier, treatment of mice with dietary cholesterol causes significant effects on a number of genes in the brain and in addition a memory impairment.
METHODS AND RESULTS:
We have suggested that these effects are mediated by 27-hydroxycholesterol, which is able to pass the blood-brain barrier. To test this hypothesis we utilized Cyp27-/- mice lacking 27-hydroxycholesterol. The negative effect on memory observed after treatment of wildtype mice with dietary cholesterol was not observed in these mice. The cholesterol diet reduced the levels of the "memory protein" Arc (Activity Regulated Cytoskeleton associated protein) in the hippocampus of the wildtype mice but not in the hippocampus of the Cyp27-/- mice.
CONCLUSIONS:
The results are consistent with 27-hydroxycholesterol as the mediator of the negative effects of cholesterol on cognition. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.4835 mL |
12.4177 mL |
24.8355 mL |
49.6709 mL |
62.0887 mL |
| 5 mM |
0.4967 mL |
2.4835 mL |
4.9671 mL |
9.9342 mL |
12.4177 mL |
| 10 mM |
0.2484 mL |
1.2418 mL |
2.4835 mL |
4.9671 mL |
6.2089 mL |
| 50 mM |
0.0497 mL |
0.2484 mL |
0.4967 mL |
0.9934 mL |
1.2418 mL |
| 100 mM |
0.0248 mL |
0.1242 mL |
0.2484 mL |
0.4967 mL |
0.6209 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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