27-羟基胆固醇

27-Hydroxycholesterol

	产品编号	CFN90609
	CAS编号	20380-11-4
	分子式 = 分子量	C₂₇H₄₆O₂ = 402.65
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
27-羟基胆固醇	CFN90609	20380-11-4	1mg	QQ客服：3257982914
27-羟基胆固醇	CFN90609	20380-11-4	5mg	QQ客服：3257982914
27-羟基胆固醇	CFN90609	20380-11-4	10mg	QQ客服：3257982914
27-羟基胆固醇	CFN90609	20380-11-4	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor, it may negatively modulate cognitive effects and cholesterol metabolism in the brain. 27-Hydroxycholesterol can enhance cell release of IL-8, IL-1β, and TNF-α and to upregulate matrix metalloproteinase-9 (MMP-9) via TLR4/NF-κB-dependent pathway; it also can reduce hepatic inflammation in hyperlipidemic mice.

Targets:

In vivo:

Neuroscience. 2015 Aug 6;300:163-73.

27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain.[Pubmed: 25987203]

Cholesterol metabolism is important for neuronal function in the central nervous system (CNS). The oxysterol 27-Hydroxycholesterol (27-OHC) is a cholesterol metabolite that crosses the blood-brain barrier (BBB) and may be a useful substitutive marker for neurodegenerative diseases. However, the effects of 27-Hydroxycholesterol on learning and memory and the underlying mechanisms are unclear.
METHODS AND RESULTS:
To determine this mechanism, we investigated learning and memory and cholesterol metabolism in rat brain following the injection of various doses of 27-Hydroxycholesterol into the caudal vein. We found that 27-Hydroxycholesterol increased cholesterol levels and upregulated the expression of liver X receptor-α (LXR-α) and adenosine triphosphate (ATP)-binding cassette transporter protein family member A1 (ABCA1). In addition, 27-Hydroxycholesterol decreased the expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CR) and low-density lipoprotein receptor (LDLR) in rat brain tissues.
CONCLUSIONS:
These findings suggest that 27-Hydroxycholesterol may negatively modulate cognitive effects and cholesterol metabolism in the brain.

Behav Brain Res. 2015 Feb 1;278:356-9.

27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice.[Pubmed: 25453744]

In spite of the fact that cholesterol does not pass the blood-brain barrier, treatment of mice with dietary cholesterol causes significant effects on a number of genes in the brain and in addition a memory impairment.
METHODS AND RESULTS:
We have suggested that these effects are mediated by 27-hydroxycholesterol, which is able to pass the blood-brain barrier. To test this hypothesis we utilized Cyp27-/- mice lacking 27-hydroxycholesterol. The negative effect on memory observed after treatment of wildtype mice with dietary cholesterol was not observed in these mice. The cholesterol diet reduced the levels of the "memory protein" Arc (Activity Regulated Cytoskeleton associated protein) in the hippocampus of the wildtype mice but not in the hippocampus of the Cyp27-/- mice.
CONCLUSIONS:
The results are consistent with 27-hydroxycholesterol as the mediator of the negative effects of cholesterol on cognition.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
蜕皮激素; Ecdysone	CFN90487	3604-87-3	C₂₇H₄₄O₆ = 464.63	5mg	QQ客服：3257982914
漏芦甾酮 B; Rhapontisterone B	CFN90522	698975-64-3	C₂₇H₄₄O₇ = 480.63	5mg	QQ客服：1413575084
20-羟基蜕皮甾酮; 20-Hydroxyecdysone	CFN98873	5289-74-7	C₂₇H₄₄O₇ = 480.6	20mg	QQ客服：215959384
水龙骨甾酮B; Polypodine B	CFN89545	18069-14-2	C₂₇H₄₄O₈ = 496.63	5mg	QQ客服：215959384
蜕皮甾酮-20,22-单丙酮化物; Ecdysterone 20,22-monoacetonide	CFN98229	22798-96-5	C₃₀H₄₈O₇ = 520.7	5mg	QQ客服：1413575084
蜕皮甾酮2,3:20,22- 二缩丙酮; Ecdysterone 2,3:20,22-diacetonide	CFN98230	22798-98-7	C₃₃H₅₂O₇ = 560.8	5mg	QQ客服：215959384
维生素D3; Vitamin D3	CFN90027	67-97-0	C₂₇H₄₄O = 384.64	20mg	QQ客服：1457312923
维生素D2; Ergocalciferol	CFN90049	50-14-6	C₂₈H₄₄O = 396.65	20mg	QQ客服：1457312923
二氢胆固醇; Dihydrocholesterol	CFN90608	80-97-7	C₂₇H₄₈O = 388.67	20mg	QQ客服：2159513211
胆固醇；胆甾醇; Cholesterol	CFN90040	57-88-5	C₂₇H₄₆O = 386.67	20mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4835 mL	12.4177 mL	24.8355 mL	49.6709 mL	62.0887 mL
5 mM	0.4967 mL	2.4835 mL	4.9671 mL	9.9342 mL	12.4177 mL
10 mM	0.2484 mL	1.2418 mL	2.4835 mL	4.9671 mL	6.2089 mL
50 mM	0.0497 mL	0.2484 mL	0.4967 mL	0.9934 mL	1.2418 mL
100 mM	0.0248 mL	0.1242 mL	0.2484 mL	0.4967 mL	0.6209 mL

27-羟基胆固醇

27-Hydroxycholesterol

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