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  • 27-羟基胆固醇

    27-Hydroxycholesterol

    27-羟基胆固醇
    产品编号 CFN90609
    CAS编号 20380-11-4
    分子式 = 分子量 C27H46O2 = 402.65
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    27-羟基胆固醇 CFN90609 20380-11-4 1mg QQ客服:2159513211
    27-羟基胆固醇 CFN90609 20380-11-4 5mg QQ客服:2159513211
    27-羟基胆固醇 CFN90609 20380-11-4 10mg QQ客服:2159513211
    27-羟基胆固醇 CFN90609 20380-11-4 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Kitasato University (Japan)
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  • University of Padjajaran (Indonesia)
  • S.N.D.T. Women's University (India)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2016, 23(4):331-9
  • International Food Research Journal2018, 25(6):2560-2571
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • Int. J. Mol. Sci.2022, 23(14),7699;
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Pharm Biol.2017, 55(1):360-366
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Molecules.2017, 22(6)
  • Biomed Sci Letters.2020, 26:319-326
  • ScientificWorldJournal.2022, 2022:4806889.
  • J Nat Med.2021, doi: 10.1007.
  • Free Radic Biol Med.2017, 112:191-199
  • Mol Microbiol.2019, 112(1):317-332
  • BMC Microbiol.2019, 19(1):78
  • Antioxidants (Basel).2020, 9(2):E99
  • Nutrients.2018, 10(12):E1998
  • Acta Agriculturae Scandinavica2015, 381-383
  • Oncol Rep.2016, 35(3):1356-64
  • Phytomedicine.2021, 2(82):153452
  • Antioxidants (Basel).2021, 10(9):1435.
  • Nutrients.2021, 13(1):254.
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • Appl. Sci. 2021, 11(22),10569
  • ...
  • 生物活性
    Description: 27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor, it may negatively modulate cognitive effects and cholesterol metabolism in the brain. 27-Hydroxycholesterol can enhance cell release of IL-8, IL-1β, and TNF-α and to upregulate matrix metalloproteinase-9 (MMP-9) via TLR4/NF-κB-dependent pathway; it also can reduce hepatic inflammation in hyperlipidemic mice.
    Targets: Liver X Receptor | HMG-CoA Reductase | LDL | TLR | TNF-α | NF-kB | MMP(e.g.TIMP) | IL Receptor | P450 (e.g. CYP17)
    In vivo:
    Neuroscience. 2015 Aug 6;300:163-73.
    27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain.[Pubmed: 25987203]
    Cholesterol metabolism is important for neuronal function in the central nervous system (CNS). The oxysterol 27-Hydroxycholesterol (27-OHC) is a cholesterol metabolite that crosses the blood-brain barrier (BBB) and may be a useful substitutive marker for neurodegenerative diseases. However, the effects of 27-Hydroxycholesterol on learning and memory and the underlying mechanisms are unclear.
    METHODS AND RESULTS:
    To determine this mechanism, we investigated learning and memory and cholesterol metabolism in rat brain following the injection of various doses of 27-Hydroxycholesterol into the caudal vein. We found that 27-Hydroxycholesterol increased cholesterol levels and upregulated the expression of liver X receptor-α (LXR-α) and adenosine triphosphate (ATP)-binding cassette transporter protein family member A1 (ABCA1). In addition, 27-Hydroxycholesterol decreased the expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CR) and low-density lipoprotein receptor (LDLR) in rat brain tissues.
    CONCLUSIONS:
    These findings suggest that 27-Hydroxycholesterol may negatively modulate cognitive effects and cholesterol metabolism in the brain.
    Behav Brain Res. 2015 Feb 1;278:356-9.
    27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice.[Pubmed: 25453744]
    In spite of the fact that cholesterol does not pass the blood-brain barrier, treatment of mice with dietary cholesterol causes significant effects on a number of genes in the brain and in addition a memory impairment.
    METHODS AND RESULTS:
    We have suggested that these effects are mediated by 27-hydroxycholesterol, which is able to pass the blood-brain barrier. To test this hypothesis we utilized Cyp27-/- mice lacking 27-hydroxycholesterol. The negative effect on memory observed after treatment of wildtype mice with dietary cholesterol was not observed in these mice. The cholesterol diet reduced the levels of the "memory protein" Arc (Activity Regulated Cytoskeleton associated protein) in the hippocampus of the wildtype mice but not in the hippocampus of the Cyp27-/- mice.
    CONCLUSIONS:
    The results are consistent with 27-hydroxycholesterol as the mediator of the negative effects of cholesterol on cognition.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4835 mL 12.4177 mL 24.8355 mL 49.6709 mL 62.0887 mL
    5 mM 0.4967 mL 2.4835 mL 4.9671 mL 9.9342 mL 12.4177 mL
    10 mM 0.2484 mL 1.2418 mL 2.4835 mL 4.9671 mL 6.2089 mL
    50 mM 0.0497 mL 0.2484 mL 0.4967 mL 0.9934 mL 1.2418 mL
    100 mM 0.0248 mL 0.1242 mL 0.2484 mL 0.4967 mL 0.6209 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蜕皮甾酮2,3:20,22- 二缩丙酮; Ecdysterone 2,3:20,22-diacetonide CFN98230 22798-98-7 C33H52O7 = 560.8 5mg QQ客服:2159513211
    维生素D3; Vitamin D3 CFN90027 67-97-0 C27H44O = 384.64 20mg QQ客服:1413575084
    维生素D2; Ergocalciferol CFN90049 50-14-6 C28H44O = 396.65 20mg QQ客服:3257982914
    二氢胆固醇; Dihydrocholesterol CFN90608 80-97-7 C27H48O = 388.67 20mg QQ客服:3257982914
    胆固醇; 胆甾醇; Cholesterol CFN90040 57-88-5 C27H46O = 386.67 20mg QQ客服:215959384
    4β-羟基胆固醇; 4-Beta-Hydroxycholesterol CFN90611 17320-10-4 C27H46O2 = 402.66 5mg QQ客服:1413575084
    7β-羟基胆固醇; 7Beta-Hydroxycholesterol CFN90610 566-27-8 C27H46O2 = 402.65 5mg QQ客服:2159513211
    7-酮基胆固醇; 7-Ketocholesterol CFN91812 566-28-9 C27H44O2 = 400.6 5mg QQ客服:2056216494
    7-氧胆固醇乙酯; 7-Oxocholesteryl acetate CFN91647 809-51-8 C29H46O3 = 442.7 5mg QQ客服:1457312923
    27-羟基胆固醇; 27-Hydroxycholesterol CFN90609 20380-11-4 C27H46O2 = 402.65 10mg QQ客服:1413575084

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