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  • 25R-牛膝甾酮

    25R-Inokosterone

    25R-牛膝甾酮
    产品编号 CFN93572
    CAS编号 19682-38-3
    分子式 = 分子量 C27H44O7 = 480.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Achyranthes bidentata Blume.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    25R-牛膝甾酮 CFN93572 19682-38-3 1mg QQ客服:3257982914
    25R-牛膝甾酮 CFN93572 19682-38-3 5mg QQ客服:3257982914
    25R-牛膝甾酮 CFN93572 19682-38-3 10mg QQ客服:3257982914
    25R-牛膝甾酮 CFN93572 19682-38-3 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Seoul National University of Science and Technology (Korea)
  • St. Jude Children Research Hospital (USA)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Universitas Airlangga (Indonesia)
  • University of Liège (Belgium)
  • MTT Agrifood Research Finland (Finland)
  • Tohoku University (Japan)
  • Georgia Institute of Technology (USA)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of Dicle (Turkey)
  • University of East Anglia (United Kingdom)
  • University of Canterbury (New Zealand)
  • Kyushu University (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Advances in Traditional Medicine2020, 10.1007
  • Phytomedicine.2022, 100:154036.
  • bioRxiv2021, 458409.
  • Molecules.2017, 22(2)
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • Food Research International2020, 108987
  • Environ Toxicol.2021, doi: 10.1002
  • Nutr Res Pract.2020, 14(5):478-489.
  • Front Pharmacol.2021, 12:652860.
  • BMC Complement Altern Med.2016, 16:213
  • Nutrients.2020, 12(12):3607.
  • Phytomedicine.2015, 22(4):498-503
  • Asian J Beauty Cosmetol2020, 18(3): 265-272.
  • J Sci Food Agric.2023, 103(1):213-220.
  • Biomed Sci Letters.2020, 26:319-326
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • Oxid Med Cell Longev2020, 12
  • J Adv Res.2021, 35:245-257.
  • Front Immunol.2020, 11:598556.
  • Bulletin of Health Research2016, 44(4):279-286
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • Anat Rec (Hoboken).2021, 304(2):323-332.
  • J Food Sci Technol.2019, 56(5):2712-2720
  • ...
  • 生物活性
    Description: 25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.
    Targets: TNF-α | IFN-γ
    In vitro:
    Journal of Applied Biological Chemistry, 2015 , 58 (1) :13-19.
    Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity[Reference: WebLink]
    The roots of Achyranthes japonica Nakai were extracted with 100% aqueous and concentrated subfraction was separated with ultra-performance liquid chromatography-based activity profiling.
    METHODS AND RESULTS:
    Three compounds were isolated from the subfraction 5 through the repeated prep- high performance liquid chromatography column chromatography. According to the results of physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compounds were determined as ecdysterone (1), 25S-inokosterone (2), and 25R-Inokosterone (3). Three phytoecdysones were showed weak inhibitory activity for thymus and activation-regulated chemokine expression levels in tumor necrosis factor (TNF)-α plus IFN-γ induced HaCaT cells, respectively. However, those compounds 1-3 were exhibited the most potent inhibition (80–95% at 200 μg/mL) against TNF-α expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells.
    CONCLUSIONS:
    As result, 100% aqueous extract of A. japonica has an excellent anti-atopy activity. It could be used to a large range of functional anti-atopy cosmetics.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0807 mL 10.4037 mL 20.8073 mL 41.6146 mL 52.0183 mL
    5 mM 0.4161 mL 2.0807 mL 4.1615 mL 8.3229 mL 10.4037 mL
    10 mM 0.2081 mL 1.0404 mL 2.0807 mL 4.1615 mL 5.2018 mL
    50 mM 0.0416 mL 0.2081 mL 0.4161 mL 0.8323 mL 1.0404 mL
    100 mM 0.0208 mL 0.104 mL 0.2081 mL 0.4161 mL 0.5202 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二氢胆固醇; Dihydrocholesterol CFN90608 80-97-7 C27H48O = 388.67 20mg QQ客服:2159513211
    胆固醇; 胆甾醇; Cholesterol CFN90040 57-88-5 C27H46O = 386.67 20mg QQ客服:215959384
    4β-羟基胆固醇; 4-Beta-Hydroxycholesterol CFN90611 17320-10-4 C27H46O2 = 402.66 5mg QQ客服:2056216494
    7β-羟基胆固醇; 7Beta-Hydroxycholesterol CFN90610 566-27-8 C27H46O2 = 402.65 5mg QQ客服:3257982914
    7-酮基胆固醇; 7-Ketocholesterol CFN91812 566-28-9 C27H44O2 = 400.6 5mg QQ客服:215959384
    7-氧胆固醇乙酯; 7-Oxocholesteryl acetate CFN91647 809-51-8 C29H46O3 = 442.7 5mg QQ客服:1457312923
    27-羟基胆固醇; 27-Hydroxycholesterol CFN90609 20380-11-4 C27H46O2 = 402.65 10mg QQ客服:215959384
    胆甾-4,6-二烯-3-醇; Cholest-4,6-diene-3-ol CFN91582 14214-69-8 C27H44O = 384.6 5mg QQ客服:1457312923
    松甾酮A; Ponasterone A CFN99419 13408-56-5 C27H44O6 = 464.6 5mg QQ客服:2056216494
    筋骨草甾酮C; Ajugasterone C CFN90616 23044-80-6 C27H44O7 = 480.64 5mg QQ客服:1457312923

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