25R-牛膝甾酮

25R-Inokosterone

	产品编号	CFN93572
	CAS编号	19682-38-3
	分子式 = 分子量	C₂₇H₄₄O₇ = 480.6
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The roots of Achyranthes bidentata Blume.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
25R-牛膝甾酮	CFN93572	19682-38-3	1mg	QQ客服：215959384
25R-牛膝甾酮	CFN93572	19682-38-3	5mg	QQ客服：215959384
25R-牛膝甾酮	CFN93572	19682-38-3	10mg	QQ客服：215959384
25R-牛膝甾酮	CFN93572	19682-38-3	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Donald Danforth Plant Science Center (USA)

Auburn University (USA)

University of Zurich (Switzerland)

University of Oslo (Norway)

Northeast Normal University Changchun (China)

Universit?t Basel (Switzerland)

University of Illinois (USA)

Warszawski Uniwersytet Medyczny (Poland)

University of Lodz (Poland)

Calcutta University (India)

Almansora University (Egypt)

Indian Institute of Science (India)

Lund University (Sweden)

Universitas islam negeri Jakarta (Indonesia)

More...

Description:

25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.

Targets:

TNF-α | IFN-γ

In vitro:

Journal of Applied Biological Chemistry, 2015 , 58 (1) :13-19.

Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity[Reference: WebLink]

The roots of Achyranthes japonica Nakai were extracted with 100% aqueous and concentrated subfraction was separated with ultra-performance liquid chromatography-based activity profiling.
METHODS AND RESULTS:
Three compounds were isolated from the subfraction 5 through the repeated prep- high performance liquid chromatography column chromatography. According to the results of physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compounds were determined as ecdysterone (1), 25S-inokosterone (2), and 25R-Inokosterone (3). Three phytoecdysones were showed weak inhibitory activity for thymus and activation-regulated chemokine expression levels in tumor necrosis factor (TNF)-α plus IFN-γ induced HaCaT cells, respectively. However, those compounds 1-3 were exhibited the most potent inhibition (80–95% at 200 μg/mL) against TNF-α expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells.
CONCLUSIONS:
As result, 100% aqueous extract of A. japonica has an excellent anti-atopy activity. It could be used to a large range of functional anti-atopy cosmetics.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
7β-羟基胆固醇; 7Beta-Hydroxycholesterol	CFN90610	566-27-8	C₂₇H₄₆O₂ = 402.65	5mg	QQ客服：3257982914
7-酮基胆固醇; 7-Ketocholesterol	CFN91812	566-28-9	C₂₇H₄₄O₂ = 400.6	5mg	QQ客服：215959384
7-氧胆固醇乙酯; 7-Oxocholesteryl acetate	CFN91647	809-51-8	C₂₉H₄₆O₃ = 442.7	5mg	QQ客服：2056216494
27-羟基胆固醇; 27-Hydroxycholesterol	CFN90609	20380-11-4	C₂₇H₄₆O₂ = 402.65	10mg	QQ客服：2159513211
胆甾-4,6-二烯-3-醇; Cholest-4,6-diene-3-ol	CFN91582	14214-69-8	C₂₇H₄₄O = 384.6	5mg	QQ客服：215959384
松甾酮A; Ponasterone A	CFN99419	13408-56-5	C₂₇H₄₄O₆ = 464.6	5mg	QQ客服：1457312923
筋骨草甾酮C; Ajugasterone C	CFN90616	23044-80-6	C₂₇H₄₄O₇ = 480.64	5mg	QQ客服：3257982914
牛膝甾酮; Inokosterone	CFN92515	15130-85-5	C₂₇H₄₄O₇ = 480.6	5mg	QQ客服：215959384
25S-牛膝甾酮; 25S-Inokosterone	CFN93571	19595-18-7	C₂₇H₄₄O₇ = 480.6	10mg	QQ客服：3257982914
25R-牛膝甾酮; 25R-Inokosterone	CFN93572	19682-38-3	C₂₇H₄₄O₇ = 480.6	10mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0807 mL	10.4037 mL	20.8073 mL	41.6146 mL	52.0183 mL
5 mM	0.4161 mL	2.0807 mL	4.1615 mL	8.3229 mL	10.4037 mL
10 mM	0.2081 mL	1.0404 mL	2.0807 mL	4.1615 mL	5.2018 mL
50 mM	0.0416 mL	0.2081 mL	0.4161 mL	0.8323 mL	1.0404 mL
100 mM	0.0208 mL	0.104 mL	0.2081 mL	0.4161 mL	0.5202 mL