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  • 松甾酮A

    Ponasterone A

    松甾酮A
    产品编号 CFN99419
    CAS编号 13408-56-5
    分子式 = 分子量 C27H44O6 = 464.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The barks of Podocarpus macrophyllus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    松甾酮A CFN99419 13408-56-5 1mg QQ客服:215959384
    松甾酮A CFN99419 13408-56-5 5mg QQ客服:215959384
    松甾酮A CFN99419 13408-56-5 10mg QQ客服:215959384
    松甾酮A CFN99419 13408-56-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Julius Kühn-Institut (Germany)
  • Melbourne University (Australia)
  • Universiti Malaysia Pahang (Malaysia)
  • National Cancer Institute (USA)
  • Monash University (Australia)
  • Weizmann Institute of Science (Israel)
  • University of South Australia (Australia)
  • Seoul National University of Science and Technology (Korea)
  • University of the Basque Country (Spain)
  • University Medical Center Mainz (Germany)
  • Indian Institute of Science (India)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Michigan State University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Eur J Pharmacol.2020, 889:173589.
  • JLiquid Chromatography & Related Tech.2021, 10826076.
  • Nat Prod Communications2018, 10.1177
  • Int J Mol Sci.2022, 23(13):7115.
  • Pak J Pharm Sci.2018, 31:311-315
  • J Med Food.2019, 22(10):1067-1077
  • Antiviral Res.2021, 193:105142.
  • Univerzita Karlova2021, 20.500.11956.
  • Agronomy2022, 12(10), 2426.
  • Nutrients2022, 14(14)2929
  • Biol Pharm Bull.2018, 41(1):65-72
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • J Biomed Sci.2020, 27(1):60.
  • Molecules.2019, 24(2):E343
  • Plant Pathology2022, 13527
  • J Sep Sci.2018, 41(7):1682-1690
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Ind Crops Prod.2014, 62:173-178
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Chem Biol Interact.2022, 368:110248.
  • Nutrients.2020, 12(12):3638.
  • Cell Biochem Funct.2018, 36(6):303-311
  • ACS Synth Biol.2022, doi: 10.1021.
  • ...
  • 生物活性
    Description: Ponasterone A is insect moulting hormone. Ponasterone A induced death of non-adapted insects may be related to PoA regulating different set of genes when compared to 20E.
    In vitro:
    Int J Biochem Cell Biol. 2003 Jan;35(1):79-85.
    Development of a ponasterone A-inducible gene expression system for application in cultured skeletal muscle cells.[Pubmed: 12467649]
    The goal of this study was to develop an inducible gene expression system to assess functions of specific proteins in differentiated cultured skeletal muscle.
    METHODS AND RESULTS:
    We utilized and modified the ecdysone inducible system because others have used this system to express exogenous genes in vitro and in transgenic animals. A limitation of the commercially-available ecdysone system is its constitutive expression in all tissues. Hence, its application in vivo would result in expression of a cloned gene in undifferentiated and differentiated tissues. To target its expression to muscle, we removed the constitutively-active CMV promoter of pVgRXR and replaced it with a skeletal muscle alpha-actin promoter so that the regulatory features of the system would be expressed in differentiated muscle cells. We transfected our newly designed expression system into L8 muscle myoblasts and established stable cell lines via antibiotic selection.
    CONCLUSIONS:
    We determined that reporter gene activity was induced by Ponasterone A in myotubes, a differentiated muscle phenotype, but not in myoblasts (undifferentiated cells). This proved the validity of the concept of an inducible muscle-specific expression system. We then determined that beta-galactosidase expression was dependent upon the dose of Ponasterone A and duration of exposure to inducer. This creates potential to regulate both the level of expression and duration of expression of a cloned gene in differentiated muscle.
    Bioorg Med Chem. 2005 Feb 15;13(4):1333-40.
    Classical and three-dimensional QSAR for the inhibition of [3H]ponasterone A binding by diacylhydrazine-type ecdysone agonists to insect Sf-9 cells.[Pubmed: 15670941]

    METHODS AND RESULTS:
    The activity of 52 diacylhydrazine congeners was evaluated by measuring the inhibition of the incorporation of [3H]Ponasterone A into intact Sf-9 cells. Eleven compounds were newly synthesized in this study. Results showed that the substitution of the 2-CH3 or 3-OCH3 moiety of methoxyfenozide with other groups or the removal of either group was unfavorable to the activity. The activity was quantitatively analyzed using both classical QSAR (Hansch-Fujita) and three-dimensional QSAR methods (comparative molecular field analysis, CoMFA). Sterically favorable fields were observed at the 3- and 4-positions of the benzene ring opposite from the t-butyl group (B-ring), and a sterically unfavorable field was evidenced at the 2-position. Another sterically unfavorable field developed surrounding the favorable field observed at the 4-position of the B-ring. Electrostatically negative fields were observed near the CO moiety, above the benzene ring, and at the 4-position of the B-ring. The optimum hydrophobicity of compounds in terms of their logP values was calculated to be approximately 4.1. Results of the three dimensional structure-activity relationship analyses were consistent with those obtained from the previously reported classical QSAR for 2-chlorobenzoyl analogs containing various para-substituents. The high activity of potent insecticides such as tebufenozide and chromafenozide were rationalized by CoMFA.
    CONCLUSIONS:
    Thus, this CoMFA result will be useful in the design of new compounds and in understanding the molecular mechanism of the ligand-receptor interactions.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1524 mL 10.7619 mL 21.5239 mL 43.0478 mL 53.8097 mL
    5 mM 0.4305 mL 2.1524 mL 4.3048 mL 8.6096 mL 10.7619 mL
    10 mM 0.2152 mL 1.0762 mL 2.1524 mL 4.3048 mL 5.381 mL
    50 mM 0.043 mL 0.2152 mL 0.4305 mL 0.861 mL 1.0762 mL
    100 mM 0.0215 mL 0.1076 mL 0.2152 mL 0.4305 mL 0.5381 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二氢胆固醇; Dihydrocholesterol CFN90608 80-97-7 C27H48O = 388.67 20mg QQ客服:2159513211
    胆固醇; 胆甾醇; Cholesterol CFN90040 57-88-5 C27H46O = 386.67 20mg QQ客服:1457312923
    4β-羟基胆固醇; 4-Beta-Hydroxycholesterol CFN90611 17320-10-4 C27H46O2 = 402.66 5mg QQ客服:1457312923
    7β-羟基胆固醇; 7Beta-Hydroxycholesterol CFN90610 566-27-8 C27H46O2 = 402.65 5mg QQ客服:1413575084
    7-酮基胆固醇; 7-Ketocholesterol CFN91812 566-28-9 C27H44O2 = 400.6 5mg QQ客服:1413575084
    7-氧胆固醇乙酯; 7-Oxocholesteryl acetate CFN91647 809-51-8 C29H46O3 = 442.7 5mg QQ客服:3257982914
    27-羟基胆固醇; 27-Hydroxycholesterol CFN90609 20380-11-4 C27H46O2 = 402.65 10mg QQ客服:1457312923
    胆甾-4,6-二烯-3-醇; Cholest-4,6-diene-3-ol CFN91582 14214-69-8 C27H44O = 384.6 5mg QQ客服:215959384
    松甾酮A; Ponasterone A CFN99419 13408-56-5 C27H44O6 = 464.6 5mg QQ客服:2159513211
    筋骨草甾酮C; Ajugasterone C CFN90616 23044-80-6 C27H44O7 = 480.64 5mg QQ客服:1457312923

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