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  • 7β-羟基胆固醇

    7Beta-Hydroxycholesterol

    7β-羟基胆固醇
    产品编号 CFN90610
    CAS编号 566-27-8
    分子式 = 分子量 C27H46O2 = 402.65
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 From Cliona copiosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7β-羟基胆固醇 CFN90610 566-27-8 1mg QQ客服:215959384
    7β-羟基胆固醇 CFN90610 566-27-8 5mg QQ客服:215959384
    7β-羟基胆固醇 CFN90610 566-27-8 10mg QQ客服:215959384
    7β-羟基胆固醇 CFN90610 566-27-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chungnam National University (Korea)
  • Utah State University (USA)
  • National Hellenic Research Foundation (Greece)
  • Tokyo Woman's Christian University (Japan)
  • Michigan State University (USA)
  • University of Eastern Finland (Finland)
  • University of Vigo (Spain)
  • Uniwersytet Medyczny w ?odzi (Poland)
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  • University of East Anglia (United Kingdom)
  • Universidad Miguel Hernández (Spain)
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  • Kyung Hee University (Korea)
  • University of Beira Interior (Portugal)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2021, 22(12):6466.
  • Molecules2021, 26(1),230
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • BMC Complement Altern Med.2016, 16:213
  • Food Chem.2021, 337:128023.
  • Archives of Biological sciences2022, 00:21-21
  • Mol Pharm.2017, 14(9):3164-3177
  • J Sep Sci.2021, 44(22):4064-4081.
  • J of Apicultural Research2020, 10.1080
  • Front Microbiol.2022, 13:835463.
  • Antioxidants (Basel).2021, 10(11):1831.
  • Sci Rep. 2018, 1-9
  • Pharmaceutics.2020, 12(9):845.
  • International. J. of Food Properties 2017, 20:S131-S140
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Cell.2018, 172(1-2):249-261
  • BMC Plant Biol.2021, 21(1):60.
  • Clin Transl Med.2021, 11(5):e392.
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Int J Mol Med.2016, 37(2):501-8
  • PLoS One.2018, 13(11):e0208055
  • LWT2020, 126:109313
  • ...
  • 生物活性
    Description: 7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. 7beta-Hydroxycholesterol and 7-ketocholesterol have dual cytotoxic effects on the cells of the vascular wall by their ability to induce apoptosis in endothelial and smooth muscle cells and necrosis in fibroblasts. 7beta-Hydroxycholesterol can inhibit the proliferation of NCI-H460 cells through apoptosis via caspase activation. It can reinforce the susceptibility of K562 adriamycin-resistant cells to this drug, it also can enhance radiosensitivity in RDM4 cells.
    Targets: LDL | Calcium Channel | MAPK | Caspase | ROS
    In vitro:
    Biol. Pharm. Bull., 2005, 28(8):1377-80.
    Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells.[Pubmed: 16079477]
    The cytotoxic activity of 7Beta-Hydroxycholesterol (7beta-OHC) was evaluated on human NCI-H460 lung cancer cells.
    METHODS AND RESULTS:
    7beta-OHC decreased clonogenic survival of NCI-H460 in a dose dependent pattern. 7beta-OHC induced apoptosis in NCI-H460, with the characteristic features like increase in sub-G(1) hypodiploid (apoptotic) cells, and apoptotic body formation, as evidenced by flow cytometry and fluorescence microscope, respectively. Apoptosis was also associated with loss of mitochondrial transmembrane potential, and the activation of caspases 9 and 3. 7beta-OHC resulted in generation of reactive oxygen species (ROS) during apoptosis.
    CONCLUSIONS:
    On the whole, the results indicated that 7beta-OHC inhibited the proliferation of NCI-H460 cells through apoptosis via caspase activation.
    Anticancer Res., 2002, 22(2A):943-8.
    Effects of combinations of 7beta-hydroxycholesterol and anticancer drugs or ionizing radiation on the proliferation of cultured tumor cells.[Pubmed: 12014676]
    Oxysterols compose a large class of natural substances endowed in a number of cases with marked antiproliferative and cytotoxic activities.
    METHODS AND RESULTS:
    The consequences of treatments combining 7Beta-Hydroxycholesterol (7beta-OHC) or XG-142 (a galactose-linked hydrosoluble derivative of 7beta-OHC) with drugs used in cancer chemotherapy or gamma radiation has been evaluated upon a variety of tumor cell lines: Hep-G2, U937, K562 cells, its adriamycin-resistant variant K562 Adr+ and RDM4. Proliferation was assessed by the Uptiblue assay and the [3H]Thymidine incorporation test.
    CONCLUSIONS:
    Results indicated that 7beta-OHC increased the sensitivity of tumor cells to adriamycin, VP-16, 5-FU and bleomycin to various degrees. 7beta-OHC was found to reinforce the susceptibility of K562 adriamycin-resistant cells to this drug. In RDM4 cells, an enhanced radiosensitivity by 7beta-OHC was also obtained, whereas XG-142 was less efficient in provoking such an effect.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4835 mL 12.4177 mL 24.8355 mL 49.6709 mL 62.0887 mL
    5 mM 0.4967 mL 2.4835 mL 4.9671 mL 9.9342 mL 12.4177 mL
    10 mM 0.2484 mL 1.2418 mL 2.4835 mL 4.9671 mL 6.2089 mL
    50 mM 0.0497 mL 0.2484 mL 0.4967 mL 0.9934 mL 1.2418 mL
    100 mM 0.0248 mL 0.1242 mL 0.2484 mL 0.4967 mL 0.6209 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-酮基胆固醇; 7-Ketocholesterol CFN91812 566-28-9 C27H44O2 = 400.6 5mg QQ客服:1413575084
    7-氧胆固醇乙酯; 7-Oxocholesteryl acetate CFN91647 809-51-8 C29H46O3 = 442.7 5mg QQ客服:215959384
    27-羟基胆固醇; 27-Hydroxycholesterol CFN90609 20380-11-4 C27H46O2 = 402.65 10mg QQ客服:215959384
    胆甾-4,6-二烯-3-醇; Cholest-4,6-diene-3-ol CFN91582 14214-69-8 C27H44O = 384.6 5mg QQ客服:3257982914
    松甾酮A; Ponasterone A CFN99419 13408-56-5 C27H44O6 = 464.6 5mg QQ客服:1413575084
    筋骨草甾酮C; Ajugasterone C CFN90616 23044-80-6 C27H44O7 = 480.64 5mg QQ客服:2056216494
    牛膝甾酮; Inokosterone CFN92515 15130-85-5 C27H44O7 = 480.6 5mg QQ客服:2056216494
    25S-牛膝甾酮; 25S-Inokosterone CFN93571 19595-18-7 C27H44O7 = 480.6 5mg QQ客服:2159513211
    25R-牛膝甾酮; 25R-Inokosterone CFN93572 19682-38-3 C27H44O7 = 480.6 5mg QQ客服:2159513211
    土克甾酮; Turkesterone CFN90217 41451-87-0 C27H44O8 = 496.64 5mg QQ客服:2159513211

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