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  • 25S-牛膝甾酮

    25S-Inokosterone

    25S-牛膝甾酮
    产品编号 CFN93571
    CAS编号 19595-18-7
    分子式 = 分子量 C27H44O7 = 480.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Achyranthes bidentata Blume.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    25S-牛膝甾酮 CFN93571 19595-18-7 1mg QQ客服:1413575084
    25S-牛膝甾酮 CFN93571 19595-18-7 5mg QQ客服:1413575084
    25S-牛膝甾酮 CFN93571 19595-18-7 10mg QQ客服:1413575084
    25S-牛膝甾酮 CFN93571 19595-18-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universita' Degli Studi Di Cagliari (Italy)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Agricultural Research Organization (ARO) (Israel)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Florida A&M University (USA)
  • Medizinische Universit?t Wien (Austria)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Rio de Janeiro State University (Brazil)
  • Mahatma Gandhi University (India)
  • CSIRO - Agriculture Flagship (Australia)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Korea Food Research Institute(KFRI) (Korea)
  • University of Hertfordshire (United Kingdom)
  • Univerzita Karlova v Praze (Czech Republic)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chemistry: X.2022, 2022.100270
  • Cells.2021, 10(11):2919.
  • J Nutr Biochem.2022, 107:109064.
  • Life (Basel).2021, 11(7):616.
  • Acta Agriculturae Scandinavica2015, 381-383
  • Korean Herb. Med. Inf.2020, 8(2):233-242.
  • Fitoterapia.2022, 157:105130.
  • Applied Biological Chemistry2021, 64(4)
  • Oncol Lett.2020, 20(4):122.
  • Phytother Res.2015, 29(7):1088-96
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Asian J Beauty Cosmetol2020, 18(3): 265-272.
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • Current Pharmaceutical Analysis2017, 13(5)
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • Molecules.2021, 26(2):E255.
  • Life Sci.2021, 286:120019.
  • Analytical Letters.2020, doi 10.1008
  • Cells.2023, 12(1):168.
  • Korean J Dent Mater2020, 47(2):63-70.
  • Food Chem.2017, 221:1135-1144
  • Cancers (Basel).2021, 13(9):2223.
  • ...
  • 生物活性
    Description: 25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.
    Targets: TNF-α | IFN-γ
    In vitro:
    Journal of Applied Biological Chemistry, 2015 , 58 (1) :13-19.
    Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity[Reference: WebLink]
    The roots of Achyranthes japonica Nakai were extracted with 100% aqueous and concentrated subfraction was separated with ultra-performance liquid chromatography-based activity profiling.
    METHODS AND RESULTS:
    Three compounds were isolated from the subfraction 5 through the repeated prep- high performance liquid chromatography column chromatography. According to the results of physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compounds were determined as ecdysterone (1), 25S-Inokosterone (2), and 25R-inokosterone (3). Three phytoecdysones were showed weak inhibitory activity for thymus and activation-regulated chemokine expression levels in tumor necrosis factor (TNF)-α plus IFN-γ induced HaCaT cells, respectively. However, those compounds 1-3 were exhibited the most potent inhibition (80–95% at 200 μg/mL) against TNF-α expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells.
    CONCLUSIONS:
    As result, 100% aqueous extract of A. japonica has an excellent anti-atopy activity. It could be used to a large range of functional anti-atopy cosmetics.
    In vivo:
    Arch Pharm Res . 2012 Aug;35(8):1449-55.
    High performance liquid chromatography used for quality control of Achyranthis Radix[Pubmed: 22941488]
    Abstract To establish a standard of quality control and to identify reliable Achyranthis Radix, three phytoecdysones including ecdysterone (1), 25R-inokosterone (2) and 25S-inokosterone (3) were determined by quantitative HPLC/UV analysis. Three phytoecdysones were separated with an YMC J'sphere ODS C(18) column (250 mm × 4.6 mm, 4 μm) by isocratic elution using 0.1% formic acid in water and acetonitrile (85:15, v/v%) as the mobile phase. The flow rate was 1.0 mL/min and the UV detector wavelength was set at 245 nm. The standards were quantified by HPLC/UV from Achyranthes bidentata Blume and Achyranthes japonica Nakai, as well as Cyathula capitata Moq. and Cyathula officinalis Kuan, which are of a different genus but are comparative herbs. The method was successfully used in the analysis of Achyranthis Radix of different geographical origin or genera with relatively simple conditions and procedures, and the assay results were satisfactory for linearity, recovery, precision, accuracy, stability and robustness. The HPLC analytical method for pattern recognition analysis was validated by repeated analysis of eighteen A. bidentata Blume samples and ten A. japonica Nakai samples. The results indicate that the established HPLC/UV method is suitable for quantitation and pattern recognition analyses for quality evaluation of Achyranthis Radix.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0807 mL 10.4037 mL 20.8073 mL 41.6146 mL 52.0183 mL
    5 mM 0.4161 mL 2.0807 mL 4.1615 mL 8.3229 mL 10.4037 mL
    10 mM 0.2081 mL 1.0404 mL 2.0807 mL 4.1615 mL 5.2018 mL
    50 mM 0.0416 mL 0.2081 mL 0.4161 mL 0.8323 mL 1.0404 mL
    100 mM 0.0208 mL 0.104 mL 0.2081 mL 0.4161 mL 0.5202 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    25S-牛膝甾酮; 25S-Inokosterone CFN93571 19595-18-7 C27H44O7 = 480.6 10mg QQ客服:3257982914
    25R-牛膝甾酮; 25R-Inokosterone CFN93572 19682-38-3 C27H44O7 = 480.6 10mg QQ客服:2159513211
    土克甾酮; Turkesterone CFN90217 41451-87-0 C27H44O8 = 496.64 5mg QQ客服:2056216494
    蜕皮激素; Ecdysone CFN90487 3604-87-3 C27H44O6 = 464.63 5mg QQ客服:215959384
    漏芦甾酮 B; Rhapontisterone B CFN90522 698975-64-3 C27H44O7 = 480.63 5mg QQ客服:2159513211
    20-羟基蜕皮甾酮; 20-Hydroxyecdysone CFN98873 5289-74-7 C27H44O7 = 480.6 20mg QQ客服:1457312923
    水龙骨甾酮B; Polypodine B CFN89545 18069-14-2 C27H44O8 = 496.63 5mg QQ客服:3257982914
    蜕皮甾酮-20,22-单丙酮化物; Ecdysterone 20,22-monoacetonide CFN98229 22798-96-5 C30H48O7 = 520.7 5mg QQ客服:1413575084
    蜕皮甾酮2,3:20,22- 二缩丙酮; Ecdysterone 2,3:20,22-diacetonide CFN98230 22798-98-7 C33H52O7 = 560.8 5mg QQ客服:1413575084
    维生素D3; Vitamin D3 CFN90027 67-97-0 C27H44O = 384.64 20mg QQ客服:2056216494

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