• 中药标准品生产商,产品定制服务
  • 石吊兰甲素

    Lysionotin

    石吊兰甲素
    产品编号 CFN99787
    CAS编号 152743-19-6
    分子式 = 分子量 C18H16O7 = 344.32
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Lysionotus pauciflorus Maxim.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    石吊兰甲素 CFN99787 152743-19-6 10mg QQ客服:3257982914
    石吊兰甲素 CFN99787 152743-19-6 20mg QQ客服:3257982914
    石吊兰甲素 CFN99787 152743-19-6 50mg QQ客服:3257982914
    石吊兰甲素 CFN99787 152743-19-6 100mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Melbourne University (Australia)
  • Universidad de Antioquia (Colombia)
  • University of Cincinnati (USA)
  • University of Limpopo (South Africa)
  • Universidad Miguel Hernández (Spain)
  • Indian Institute of Science (India)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Siksha O Anusandhan University (India)
  • University of Perugia (Italy)
  • The Australian National University (Australia)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Wroclaw Medical University (Poland)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Phytomedicine.2015, 22(14):1262-8
  • Mol Immunol. 2016, 78:121-132
  • International. J. of Food Properties 2017, 20:S131-S140
  • J Ethnopharmacol.2017, 209:305-316
  • Biol Pharm Bull.2017, 40(6):797-806
  • Mol Cell.2017, 68(4):673-685
  • RSC Advances2017, 86
  • Drug Test Anal.2018, 10(10):1579-1589
  • Nat Prod Communications2018, 10.1177
  • Molecules.2018, 23(3):E615
  • Pak J Pharm Sci.2018, 31:311-315
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Primary and Industrial.2018, 52(11)
  • Phytother Res.2019, 10.1002
  • Postharvest Biol Tec2019, 149:18-26
  • Int J Mol Sci.2019, 20(3):E651
  • Food Chem.2019, 278:683-691
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Genes Genomics.2020, 10.1007
  • Food Research International2020, 108987
  • Neurochem Int.2020, 133:104629
  • Industrial Crops and Products2020, 146:112186
  • ...
  • 生物活性
    Description: Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities. It is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo.
    In vitro:
    Appl Microbiol Biotechnol. 2017 Sep;101(17):6697-6703.
    Lysionotin attenuates Staphylococcus aureus pathogenicity by inhibiting α-toxin expression.[Pubmed: 28710557 ]
    α-Toxin, one of the best known pore-forming proteins produced by Staphylococcus aureus (S. aureus), is a critical virulence factor in multiple infections. The necessity of α-toxin for S. aureus pathogenicity suggests that this toxin is an important target for the development of a potential treatment strategy.
    METHODS AND RESULTS:
    In this study, we showed that lysionotin, a natural compound, can inhibit the hemolytic activity of culture supernatants by S. aureus by reducing α-toxin expression. Using real-time PCR analysis, we showed that transcription of hla (the gene encoding α-toxin) and agr (the locus regulating hla) was significantly inhibited by lysionotin. Lactate dehydrogenase and live/dead assays indicated that lysionotin effectively protected human alveolar epithelial cells against S. aureus, and in vivo studies also demonstrated that lysionotin can protect mice from pneumonia caused by S. aureus. These findings suggest that lysionotin is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo.
    CONCLUSIONS:
    This study supports a potential strategy for the treatment of S. aureus infection by inhibiting the expression of virulence factors and indicates that lysionotin may be a potential treatment for S. aureus pneumonia.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9043 mL 14.5214 mL 29.0428 mL 58.0855 mL 72.6069 mL
    5 mM 0.5809 mL 2.9043 mL 5.8086 mL 11.6171 mL 14.5214 mL
    10 mM 0.2904 mL 1.4521 mL 2.9043 mL 5.8086 mL 7.2607 mL
    50 mM 0.0581 mL 0.2904 mL 0.5809 mL 1.1617 mL 1.4521 mL
    100 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5809 mL 0.7261 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 5mg QQ客服:215959384
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:2932563308
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:1148253675
    黄花夹竹桃黄酮; Thevetiaflavone CFN96124 29376-68-9 C16H12O5 = 284.3 5mg QQ客服:1413575084
    野黄芩素; Scutellarein CFN98557 529-53-3 C15H10O6 = 286.24 20mg QQ客服:2159513211
    高车前素; Hispidulin CFN99491 1447-88-7 C16H12O6 = 300.3 20mg QQ客服:2159513211
    蓟黄素; Cirsimaritin CFN97126 6601-62-3 C17H14O6 = 314.3 5mg QQ客服:2159513211
    4'-羟基汉黄芩素; 4'-Hydroxywogonin CFN98960 57096-02-3 C16H12O6 = 300.3 10mg QQ客服:1413575084
    5,8-二羟基-2-(4-羟基苯基)-6,7-二甲氧基-4H- 1-苯并吡喃-4-酮; Isothymusin CFN97562 98755-25-0 C17H14O7 = 330.3 5mg QQ客服:1148253675
    金合欢素; 刺槐素; Acacetin CFN98744 480-44-4 C16H12O5 = 284.3 20mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产