石吊兰甲素

Lysionotin

	产品编号	CFN99787
	CAS编号	152743-19-6
	分子式 = 分子量	C₁₈H₁₆O₇ = 344.32
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The herbs of Lysionotus pauciflorus Maxim.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
石吊兰甲素	CFN99787	152743-19-6	10mg	QQ客服：215959384
石吊兰甲素	CFN99787	152743-19-6	20mg	QQ客服：215959384
石吊兰甲素	CFN99787	152743-19-6	50mg	QQ客服：215959384
石吊兰甲素	CFN99787	152743-19-6	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Regional Crop Research Institute (Korea)

University of Maryland School of Medicine (USA)

Rio de Janeiro State University (Brazil)

Centrum Menselijke Erfelijkheid (Belgium)

University of Queensland (Australia)

National Research Council of Canada (Canada)

Monash University (Australia)

Utrecht University (Netherlands)

Kamphaengphet Rajabhat University (Thailand)

Max Rubner-Institut (MRI) (Germany)

Korea Food Research Institute(KFRI) (Korea)

The Australian National University (Australia)

University of Illinois at Chicago (USA)

Technical University of Denmark (Denmark)

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Description:

Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities. It is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo.

In vitro:

Appl Microbiol Biotechnol. 2017 Sep;101(17):6697-6703.

Lysionotin attenuates Staphylococcus aureus pathogenicity by inhibiting α-toxin expression.[Pubmed: 28710557 ]

α-Toxin, one of the best known pore-forming proteins produced by Staphylococcus aureus (S. aureus), is a critical virulence factor in multiple infections. The necessity of α-toxin for S. aureus pathogenicity suggests that this toxin is an important target for the development of a potential treatment strategy.
METHODS AND RESULTS:
In this study, we showed that lysionotin, a natural compound, can inhibit the hemolytic activity of culture supernatants by S. aureus by reducing α-toxin expression. Using real-time PCR analysis, we showed that transcription of hla (the gene encoding α-toxin) and agr (the locus regulating hla) was significantly inhibited by lysionotin. Lactate dehydrogenase and live/dead assays indicated that lysionotin effectively protected human alveolar epithelial cells against S. aureus, and in vivo studies also demonstrated that lysionotin can protect mice from pneumonia caused by S. aureus. These findings suggest that lysionotin is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo.
CONCLUSIONS:
This study supports a potential strategy for the treatment of S. aureus infection by inhibiting the expression of virulence factors and indicates that lysionotin may be a potential treatment for S. aureus pneumonia.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
金合欢素；刺槐素; Acacetin	CFN98744	480-44-4	C₁₆H₁₂O₅ = 284.3	20mg	QQ客服：215959384
5-羟基-4’,7-二甲氧基黄酮; 7,4'-Di-O-methylapigenin	CFN98819	5128-44-9	C₁₇H₁₄O₅ = 298.3	5mg	QQ客服：1457312923
三甲基芹菜素; Trimethylapigenin	CFN91890	5631-70-9	C₁₈H₁₆O₅ = 312.32	20mg	QQ客服：2159513211
5,6-二羟基-7,4'-二甲氧基黄酮; Ladanein	CFN96380	10176-71-3	C₁₇H₁₄O₆ = 314.3	5mg	QQ客服：1457312923
柳穿鱼黄素; Pectolinarigenin	CFN99010	520-12-7	C₁₇H₁₄O₆ = 314.3	20mg	QQ客服：3257982914
三裂鼠尾草素; Salvigenin	CFN99883	19103-54-9	C₁₈H₁₆O₆ = 328.3	10mg	QQ客服：2159513211
4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone	CFN91034	1168-42-9	C₁₉H₁₈O₆ = 342.4	5mg	QQ客服：2159513211
4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin	CFN93255	6601-66-7	C₁₉H₁₈O₆ = 342.4	10mg	QQ客服：2056216494
石吊兰甲素; Lysionotin	CFN99787	152743-19-6	C₁₈H₁₆O₇ = 344.32	20mg	QQ客服：215959384
栀子黄素B; Gardenin B	CFN93144	2798-20-1	C₁₉H₁₈O₇ = 358.4	10mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9043 mL	14.5214 mL	29.0428 mL	58.0855 mL	72.6069 mL
5 mM	0.5809 mL	2.9043 mL	5.8086 mL	11.6171 mL	14.5214 mL
10 mM	0.2904 mL	1.4521 mL	2.9043 mL	5.8086 mL	7.2607 mL
50 mM	0.0581 mL	0.2904 mL	0.5809 mL	1.1617 mL	1.4521 mL
100 mM	0.029 mL	0.1452 mL	0.2904 mL	0.5809 mL	0.7261 mL