Info: Read More
  • 中药标准品生产商,产品定制服务
  • Science | Nature | Cell | View More

    桔皮素

    Tangeretin

    桔皮素
    产品编号 CFN90240
    CAS编号 481-53-8
    分子式 = 分子量 C20H20O7 = 372.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The peels of Citrus aurantium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    桔皮素 CFN90240 481-53-8 10mg QQ客服:3257982914
    桔皮素 CFN90240 481-53-8 20mg QQ客服:3257982914
    桔皮素 CFN90240 481-53-8 50mg QQ客服:3257982914
    桔皮素 CFN90240 481-53-8 100mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Colorado State University (USA)
  • Celltrion Chemical Research Institute (Korea)
  • Universitas Airlangga (Indonesia)
  • Sri Ramachandra University (India)
  • University of Virginia (USA)
  • Texas A&M University (USA)
  • University of Hawaii Cancer Center (USA)
  • Donald Danforth Plant Science Center (USA)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • St. Jude Children Research Hospital (USA)
  • University of Indonesia (Indonesia)
  • Korea Institute of Oriental Medicine (Korea)
  • Wageningen University (Netherlands)
  • University of Bordeaux (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Cells.2015, 38(9):765-72
  • Sci Rep.2015, 5:13194
  • Food Chem.2016, 191:81-90
  • Molecules.2016, 21(6)
  • J Exp Bot.2016, 67(12):3777-88
  • Molecules.2017, 22(2)
  • J Food Compos Anal2017, 62:197-204
  • Exp Neurobiol.2018, 27(3):200-209
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Front Pharmacol.2019, 10:1025
  • Front Pharmacol.2019, 10:1355
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • J Nat Prod.2019, 82(4):1002-1008
  • Process Biochemistry2019, 87:213-220
  • Drug Des Devel Ther.2020, 14:61-71
  • Antioxidants (Basel).2020, 9(2):E120
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • Biomed Pharmacother.2020, 131:110673.
  • Analytical sci. & Tech2020, 33(5):224-231
  • J Appl Toxicol.2020, 40(7):965-978.
  • Antioxidants (Basel).2020, 9(6):466.
  • ...
  • 生物活性
    Description: Tangeretin is a Notch-1 inhibitor, has antiproliferative, antiinvasive, antimetastatic and antioxidant activities.Tangeretin has therapeutic potential for melanoma and melanoma-associated depigmentation, because it can induce hyperpigmentation through the activation of melanogenic signaling proteins and initiation of sustained ERK2 expression.
    Targets: ERK | NO | Tyrosinase | Notch-1 | Jagged1/2 | Hey-1 | Hes-1
    In vitro:
    Nat Prod Commun. 2015 Mar;10(3):389-92.
    Tangeretin triggers melanogenesis through the activation of melanogenic signaling proteins and sustained extracellular signal- regulated kinase in B16/F10 murine melanoma cells.[Pubmed: 25924512]
    In order to test the effectiveness of tangeretin at ameliorating melanoma and melanoma-associated depigmentation, western blotting was used to assess the melanin content of treated melanoma cells.
    METHODS AND RESULTS:
    Tangeretin, a 4',5,6,7,8-pentamethoxyflavone, was found to trigger intracellular melanin production in a concentration-dependent manner in B16/F10 murine melanoma cells. Melanin content increased 1.74-fold in response to treatment with 25 μM of tangeretin, compared to that in non-treated cells. Examination of melanogenic protein expression showed that tyrosinase, tyrosinase-related protein (TRP)-1, and extracellular signal-regulated kinase (ERK) 1/2 levels increased in a dose-dependent manner. Furthermore, the expression of cyclic adenosine monophosphate response element binding protein (CREB) and microphthalmia transcription factor (MITF) was increased by tangeretin in 1 h and 4 h, respectively. Tangeretin- upregulated melanogenesis was suppressed by ERK 1/2 inhibitor and not by ERK1 inhibitor.
    CONCLUSIONS:
    These results suggest that tangeretin has therapeutic potential for melanoma and melanoma-associated depigmentation because it can induce hyperpigmentation through the activation of melanogenic signaling proteins and initiation of sustained ERK2 expression.
    In vivo:
    Oncol Rep. 2015 Jul;34(1):302-10.
    Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells.[Pubmed: 25998143]
    Irradiation has been reported to increase radioresistance and epithelial-mesenchymal transition (EMT) in gastric cancer (GC) cells. The Notch pathway is critically implicated in cancer EMT and radioresistance. In the present study, we investigated the use of a Notch-1 inhibiting compound as a novel therapeutic candidate to regulate radiation-induced EMT in GC cells.
    METHODS AND RESULTS:
    According to previous screening, tangeretin, a polymethoxylated flavonoid from citrus fruits was selected as a Notch-1 inhibitor. Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagged1/2, Hey-1 and Hes-1 expressions. Tangeretin triggered the upregulation of miR-410, a tumor-suppressive microRNA. Furthermore, re-expression of miR-410 prevented radiation-induced EMT and cell invasion. An in vivo tumor xenograft model confirmed the antimetastasis effect of tangeretin as we observed in vitro. In nude mice, tumor size was considerably diminished by radiation plus tangeretin co-treatment. Tangeretin almost completely inhibited lung metastasis induced by irradiation.
    CONCLUSIONS:
    Tangeretin may be a novel antimetastatic agent for radiotherapy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6855 mL 13.4275 mL 26.855 mL 53.71 mL 67.1375 mL
    5 mM 0.5371 mL 2.6855 mL 5.371 mL 10.742 mL 13.4275 mL
    10 mM 0.2686 mL 1.3428 mL 2.6855 mL 5.371 mL 6.7138 mL
    50 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.0742 mL 1.3428 mL
    100 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.5371 mL 0.6714 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蓟黄素; Cirsimaritin CFN97126 6601-62-3 C17H14O6 = 314.3 5mg QQ客服:1457312923
    4'-羟基汉黄芩素; 4'-Hydroxywogonin CFN98960 57096-02-3 C16H12O6 = 300.3 10mg QQ客服:1457312923
    5,8-二羟基-2-(4-羟基苯基)-6,7-二甲氧基-4H- 1-苯并吡喃-4-酮; Isothymusin CFN97562 98755-25-0 C17H14O7 = 330.3 5mg QQ客服:2159513211
    金合欢素; 刺槐素; Acacetin CFN98744 480-44-4 C16H12O5 = 284.3 20mg QQ客服:1413575084
    5-羟基-4’,7-二甲氧基黄酮; 7,4'-Di-O-methylapigenin CFN98819 5128-44-9 C17H14O5 = 298.3 5mg QQ客服:2056216494
    三甲基芹菜素; Trimethylapigenin CFN91890 5631-70-9 C18H16O5 = 312.32 5mg QQ客服:3257982914
    5,6-二羟基-7,4'-二甲氧基黄酮; Ladanein CFN96380 10176-71-3 C17H14O6 = 314.3 5mg QQ客服:2159513211
    柳穿鱼黄素; Pectolinarigenin CFN99010 520-12-7 C17H14O6 = 314.3 20mg QQ客服:2159513211
    三裂鼠尾草素; Salvigenin CFN99883 19103-54-9 C18H16O6 = 328.3 10mg QQ客服:2056216494
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:3257982914

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ1: 2056216494 ; QQ2: 3257982914
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产