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  • 4',5,6,7-四甲氧基黄酮

    4',5,6,7-Tetramethoxyflavone

    4',5,6,7-四甲氧基黄酮
    产品编号 CFN91034
    CAS编号 1168-42-9
    分子式 = 分子量 C19H18O6 = 342.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria baicalensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4',5,6,7-四甲氧基黄酮 CFN91034 1168-42-9 1mg QQ客服:1413575084
    4',5,6,7-四甲氧基黄酮 CFN91034 1168-42-9 5mg QQ客服:1413575084
    4',5,6,7-四甲氧基黄酮 CFN91034 1168-42-9 10mg QQ客服:1413575084
    4',5,6,7-四甲氧基黄酮 CFN91034 1168-42-9 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Pennsylvania State University (USA)
  • Universidade de Franca (Brazil)
  • Technical University of Denmark (Denmark)
  • The Institute of Cancer Research (United Kingdom)
  • Helmholtz Zentrum München (Germany)
  • Kazusa DNA Research Institute (Japan)
  • Chang Gung University (Taiwan)
  • Mendel University in Brno (Czech Republic)
  • Chiang Mai University (Thailand)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Vigo (Spain)
  • Griffith University (Australia)
  • Agricultural Research Organization (ARO) (Israel)
  • Siksha O Anusandhan University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:242
  • Am J Chin Med.2015, 30:1-22
  • Tumour Biol.2015, 36(12):9385-93
  • J Ethnopharmacol.2016, 194:219-227
  • Molecules.2016, 21(6)
  • Biomed Chromatogr.2016, 30(10):1573-81
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Sci Rep.2017, 7:46299
  • LWT-Food Science and Technology2017, 75:488-496
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • Nutrients.2018, 11(1):E17
  • Nat Prod Sci.2018, 24(3):206
  • South African J of Plant&Soil2018, 29-32
  • Biofactors.2018, 44(2):168-179
  • J of Health Science and Alternative Medicine2019, 1(1)
  • J Cancer.2019, 10(23):5843-5851
  • Industrial Crops and Products2019, 140:111612
  • Int J Mol Sci.2019, 20(14):E3538
  • Antioxidants (Basel).2019, 8(8):E307
  • Biomed Chromatogr.2019, 8:e4774
  • Sci Rep.2019, 9:12132
  • Industrial Crops and Products2020, 146:112186
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • ...
  • 生物活性
    Description: 4',5,6,7-Tetramethoxyflavone has a hemostatic effect.
    Targets: PAFR
    In vitro:
    Molecules. 2011 Jun 10;16(6):4828-35.
    Flavonoids from Praxelis clematidea R.M. King and Robinson modulate bacterial drug resistance.[Pubmed: 21666549]

    METHODS AND RESULTS:
    Chemical studies of Praxelis clematidea R.M. King & Robinson resulted in the isolation of six flavones: Apigenine, genkwanine, 7,4'-dimethylapigenin, trimethylapigenin, cirsimaritin and tetramethylscutellarein, which were tested for their toxicity against Staphylococcus aureus SA-1199B, a strain possessing the NorA efflux pump. Efflux pumps are integral proteins of the bacterial membrane and are recognized as one of the main causes of bacterial drug resistance, since they expel antibiotics from the cell. The inhibition of this transporter is one form of modulating bacterial resistance to antimicrobial drugs. The flavones tested did not show any significant antibacterial activity against the Staphylococcus aureus strain used, but were able to modulate bacterial drug resistance.
    CONCLUSIONS:
    This property might be related to the degree of lipophilicity of the flavones conferred by the methoxyl groups, since 4',5,6,7-Tetramethoxyflavone the most methoxylated compound, reduced the minimal inhibitory concentration of the drug 16-fold.
    J Med Assoc Thai. 1991 May;74(5):283-7.
    Effect of Eupatorium odoratum on blood coagulation.[Pubmed: 1783877]

    METHODS AND RESULTS:
    The purified compound, 4',5,6,7-Tetramethoxyflavone, is an active ingredient isolated from Eupatorium odoratum, a Thai indigenous plant that has long been used to stop bleeding. This compound was studied in vitro for the effect on blood clotting factor activities. It was found that the compound enhanced blood coagulation, the observed APTT being shorter than that observed in the control.
    CONCLUSIONS:
    The result suggested that the compound accelerated clotting time through the intrinsic pathway of the coagulation which may involve the reaction of factor XII, factor XI, factor IX or factor VIII.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9206 mL 14.6028 mL 29.2056 mL 58.4112 mL 73.014 mL
    5 mM 0.5841 mL 2.9206 mL 5.8411 mL 11.6822 mL 14.6028 mL
    10 mM 0.2921 mL 1.4603 mL 2.9206 mL 5.8411 mL 7.3014 mL
    50 mM 0.0584 mL 0.2921 mL 0.5841 mL 1.1682 mL 1.4603 mL
    100 mM 0.0292 mL 0.146 mL 0.2921 mL 0.5841 mL 0.7301 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柳穿鱼黄素; Pectolinarigenin CFN99010 520-12-7 C17H14O6 = 314.3 20mg QQ客服:1148253675
    三裂鼠尾草素; Salvigenin CFN99883 19103-54-9 C18H16O6 = 328.3 10mg QQ客服:1413575084
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:2159513211
    4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin CFN93255 6601-66-7 C19H18O6 = 342.4 5mg QQ客服:2159513211
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:2159513211
    栀子黄素B; Gardenin B CFN93144 2798-20-1 C19H18O7 = 358.4 10mg QQ客服:215959384
    桔皮素; Tangeretin CFN90240 481-53-8 C20H20O7 = 372.37 20mg QQ客服:3257982914
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 5mg QQ客服:2932563308
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:1148253675
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:215959384

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