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  • 5,6-二羟基-7,4'-二甲氧基黄酮

    Ladanein

    5,6-二羟基-7,4'-二甲氧基黄酮
    产品编号 CFN96380
    CAS编号 10176-71-3
    分子式 = 分子量 C17H14O6 = 314.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Marrubium vulgare.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5,6-二羟基-7,4'-二甲氧基黄酮 CFN96380 10176-71-3 1mg QQ客服:215959384
    5,6-二羟基-7,4'-二甲氧基黄酮 CFN96380 10176-71-3 5mg QQ客服:215959384
    5,6-二羟基-7,4'-二甲氧基黄酮 CFN96380 10176-71-3 10mg QQ客服:215959384
    5,6-二羟基-7,4'-二甲氧基黄酮 CFN96380 10176-71-3 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Korea Food Research Institute(KFRI) (Korea)
  • Universidade da Beira Interior (Germany)
  • Seoul National University of Science and Technology (Korea)
  • University of Bordeaux (France)
  • Copenhagen University (Denmark)
  • University of Illinois (USA)
  • University of Wisconsin-Madison (USA)
  • University of Cincinnati (USA)
  • Mendel University in Brno (Czech Republic)
  • Chulalongkorn University (Thailand)
  • Institute of Chinese Materia Medica (China)
  • Medizinische Universit?t Wien (Austria)
  • Semmelweis Unicersity (Hungary)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2015, 12(5):7789-95
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Biochem Pharmacol.2017, 130:10-20
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Sci Rep.2017, 7:46299
  • Front Plant Sci.2017, 8:723
  • J Nat Prod.2017, 80(4):854-863
  • Neurochem Int.2018, 121:114-124
  • PLoS One.2018, 13(3):e0193386
  • BMC Complement Altern Med.2018, 18(1):221
  • Int J Mol Sci.2018, 19(9):E2681
  • International Food Research Journal2018, 25(6):2560-2571
  • Academic J of Second Military Medical University2018, 39(11)
  • Sci Rep.2018, 8:15059
  • Nat Commun.2019, 10(1):5169
  • Neuropharmacology2019, 151437
  • J of Essential Oil Research2019, 1677272
  • Med Sci Monit.2019, 25:9499-9508
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • J Funct Foods2019, 54:449-456
  • Pest Manag Sci.2019, 75(9):2530-2541
  • Antioxidants (Basel).2019, 8(8):E307
  • Food Chem Toxicol.2020, 135:110863
  • ...
  • 生物活性
    Description: Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins.Ladanein possesses free radicals DPPH and ABTS +.scavenging activity, it also displays moderate (20-40 microM) activities against K562, K562R (imatinib-resistant), and 697 human leukemia cell lines.
    Targets: HCV
    In vitro:
    Planta Med. 2010 Jan;76(1):86-7. doi:
    Activity of ladanein on leukemia cell lines and its occurrence in Marrubium vulgare.[Pubmed: 19644796 ]

    METHODS AND RESULTS:
    Three methoxylated flavones isolated from Marrubium peregrinum - Ladanein, scutellarein-5,7,4'-trimethyl ether, and scutellarein-5,6,7,4'-tetramethyl ether - were assayed for their cytotoxicity towards a recently developed dasatinib-resistant murine leukemia cell line (DA1-3b/M2 (BCR-ABL)), together with the structurally related non-methylated flavone scutellarein. The most active compound, Ladanein, was looked for in 20 common Lamiaceae species by a quick HPLC screening. Among the possible positive results, the most interesting source was found to be Marrubium vulgare, which led to the isolation and identification of Ladanein for the first time in this species. Ladanein also displayed moderate (20-40 microM) activities against K562, K562R (imatinib-resistant), and 697 human leukemia cell lines but was toxic neither to MOLM13 nor to human peripheral blood mononuclear cells.
    METHODS AND RESULTS:
    This work provides a common natural source for the hemi-synthesis of future Ladanein-derived flavones and the study of their antileukemic activity.
    Food Chemistry,2012,130(3):695-701.
    Isolation, identification and activity of natural antioxidants from horehound ( Marrubium vulgare L.) cultivated in Lithuania[Reference: WebLink]

    METHODS AND RESULTS:
    In an earlier screening of Lithuanian plants, horehound ( Marrubium vulgare ) showed good antioxidant activity and as this species is used in herbal teas and cough pastilles it was selected for further investigation. Some fractions of the aerial parts were strong scavengers of the model free radicals DPPH and ABTS + . Activity in the β -carotene bleaching assay and the rapeseed oil oxidation assay was lower. Several active compounds were observed in the crude methanol–water extract, and in butanol and methyl tert -butyl ether fractions using HPLC with on-line radical scavenging detection. After multi-step fractionation of these fractions five compounds possessing radical scavenging activity were purified and their structures were elucidated by NMR and MS as 5,6-dihydroxy-7,4′-dimethoxyflavone (syn. Ladanein), 7- O - β -glucopyranosyl luteolin, 7- O - β -glucuronyl luteolin, verbascoside and forsythoside B.
    CONCLUSIONS:
    Their activities were tested in off-line DPPH and ABTS + free radical scavenging assays, and compared with the antioxidants rosmarinic acid and Trolox.
    Bioinform Biol Insights. 2014 Jun 23;8:159-68.
    In Silico Studies of Medicinal Compounds Against Hepatitis C Capsid Protein from North India[Pubmed: 25002815]
    Hepatitis viral infection is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Over one million people are estimated to be persistently infected with hepatitis C virus (HCV) worldwide. As capsid core protein is the key element in spreading HCV; hence, it is considered to be the superlative target of antiviral compounds. Novel drug inhibitors of HCV are in need to complement or replace the current treatments such as pegylated interferon's and ribavirin as they are partially booming and beset with various side effects. Our study was conducted to predict 3D structure of capsid core protein of HCV from northern part of India. Core, the capsid protein of HCV, handles the assembly and packaging of HCV RNA genome and is the least variable of all the ten HCV proteins among the six HCV genotypes.
    METHODS AND RESULTS:
    Therefore, we screened four phytochemicals inhibitors that are known to disrupt the interactions of core and other HCV proteins such as (a) epigallocatechin gallate (EGCG), (b) Ladanein, (c) naringenin, and (d) silybin extracted from medicinal plants; targeted against active site of residues of HCV-genotype 3 (G3) (Q68867) and its subtypes 3b (Q68861) and 3g (Q68865) from north India. To study the inhibitory activity of the recruited flavonoids, we conducted a quantitative structure-activity relationship (QSAR). Furthermore, docking interaction suggests that EGCG showed a maximum number of hydrogen bond (H-bond) interactions with all the three modeled capsid proteins with high interaction energy followed by naringenin and silybin.
    CONCLUSIONS:
    Thus, our results strongly correlate the inhibitory activity of the selected bioflavonoid. Finally, the dynamic predicted capsid protein molecule of HCV virion provides a general avenue to target structure-based antiviral compounds that support the hypothesis that the screened inhibitors for viral capsid might constitute new class of potent agents but further confirmation is necessary using in vitro and in vivo studies.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1817 mL 15.9084 mL 31.8167 mL 63.6335 mL 79.5418 mL
    5 mM 0.6363 mL 3.1817 mL 6.3633 mL 12.7267 mL 15.9084 mL
    10 mM 0.3182 mL 1.5908 mL 3.1817 mL 6.3633 mL 7.9542 mL
    50 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.2727 mL 1.5908 mL
    100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6363 mL 0.7954 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 5mg QQ客服:3257982914
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:1148253675
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:2932563308
    黄花夹竹桃黄酮; Thevetiaflavone CFN96124 29376-68-9 C16H12O5 = 284.3 5mg QQ客服:1413575084
    野黄芩素; Scutellarein CFN98557 529-53-3 C15H10O6 = 286.24 20mg QQ客服:215959384
    高车前素; Hispidulin CFN99491 1447-88-7 C16H12O6 = 300.3 20mg QQ客服:215959384
    蓟黄素; Cirsimaritin CFN97126 6601-62-3 C17H14O6 = 314.3 5mg QQ客服:215959384
    4'-羟基汉黄芩素; 4'-Hydroxywogonin CFN98960 57096-02-3 C16H12O6 = 300.3 10mg QQ客服:215959384
    5,8-二羟基-2-(4-羟基苯基)-6,7-二甲氧基-4H- 1-苯并吡喃-4-酮; Isothymusin CFN97562 98755-25-0 C17H14O7 = 330.3 5mg QQ客服:215959384
    金合欢素; 刺槐素; Acacetin CFN98744 480-44-4 C16H12O5 = 284.3 20mg QQ客服:3257982914

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