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    4,5,7,8,-四甲氧基黄酮

    6-Demethoxytangeretin

    4,5,7,8,-四甲氧基黄酮
    产品编号 CFN93255
    CAS编号 6601-66-7
    分子式 = 分子量 C19H18O6 = 342.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Andrographis paniculata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4,5,7,8,-四甲氧基黄酮 CFN93255 6601-66-7 1mg QQ客服:1413575084
    4,5,7,8,-四甲氧基黄酮 CFN93255 6601-66-7 5mg QQ客服:1413575084
    4,5,7,8,-四甲氧基黄酮 CFN93255 6601-66-7 10mg QQ客服:1413575084
    4,5,7,8,-四甲氧基黄酮 CFN93255 6601-66-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Amsterdam (Netherlands)
  • Lund University (Sweden)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Utrecht University (Netherlands)
  • University of Toulouse (France)
  • University of Virginia (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Biochim Pol.2015, 62(2):253-8
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Front Pharmacol.2016, 7:460
  • Pharmacognosy Magazine2017, 13(52):868-874
  • J Nat Med.2017, 71(2):457-462
  • Front Immunol.2017, 8:1542
  • Int. J. of Food Properties2017, S108-S118
  • Exp Neurobiol.2018, 27(3):200-209
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Eur J Pharmacol.2018, 832:96-103
  • Planta Med.2018, 84(15):1101-1109
  • J Sci Food Agric.2018, 98(3):1153-1161
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Anal Sci.2019, 35(12):1317-1325
  • Appl Biol Chem2019, 62:46
  • Phytomedicine.2019, 67:153159
  • Process Biochemistry2019, 87:213-220
  • South African J of Botany2020, 135:50-57
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • Biomed Sci Letters.2020, 26:319-326
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • Biology (Basel).2020, 9(11):363.
  • ...
  • 生物活性
    Description: 6-Demethoxytangeretin has anti-inflammatory activity, it also can suppress production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. 6-Demethoxytangeretin can suppress the interleukin 1 (IL-1) induced production of proMMP-9/progelatinase B in rabbit synovial cells in a dose dependent manner (<64 microM).
    Targets: ALK | IL Receptor | MMP(e.g.TIMP) | ERK | Beta Amyloid | MAPK | PGE
    In vitro:
    Biol Pharm Bull. 2013;36(10):1646-9.
    6-demethoxynobiletin, a nobiletin-analog citrus flavonoid, enhances extracellular signal-regulated kinase phosphorylation in PC12D cells.[Pubmed: 23934345]
    We previously demonstrated that nobiletin, a polymethoxylated flavone isolated from citrus peels, has the potential to improve cognitive dysfunction in patients with Alzheimer's disease (AD). Recent studies suggest that the generation of intraneuronal amyloid-beta (Aβ) oligomers is an early event in the pathogenesis of AD. Aβ oligomers cause deficits in the regulation of the extracellular signal-regulated kinase (ERK) signaling which is critical for consolidation of the memory. Our previous studies revealed that nobiletin activated ERK signaling and subsequent cyclic AMP response element-dependent transcription.
    METHODS AND RESULTS:
    In this study, the effects of five nobiletin analogs, 6-demethoxynobiletin, tangeretin, 5-demethylnobiletin, sinensetin, and 6-demethoxytangeretin, isolated from citrus peels were assessed on ERK phosphorylation in PC12D cells, and the structure-activity relationships were examined. PC12D cells were treated with nobiletin or its analogs, and the cell extracts were analyzed by Western blotting using an antibody specific to phosphorylated ERK. 6-Demethoxynobiletin markedly enhanced ERK phosphorylation in a concentration-dependent manner.
    CONCLUSIONS:
    These results may be useful in developing drugs and functional foods using citrus peels for the treatment of dementia including AD.
    J Rheumatol. 2000 Jan;27(1):20-5.
    A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts.[Pubmed: 10648013]
    Flavonoids including nobiletin are known to exert many biological actions in vitro. We investigated the chondroprotective effect of citrus flavonoids, especially nobiletin, using cultured rabbit synovial fibroblasts and articular chondrocytes.
    METHODS AND RESULTS:
    We examined the effects of citrus flavonoids on the production and gene expression of matrix metalloproteinases (MMP) and prostaglandin E2 (PGE2)production in rabbit synovial fibroblasts. Six flavonoids isolated from Citrus depressa Rutaceae including tangeretin, 6-demethoxytangeretin, nobiletin, 5-demethylnobiletin, 6-demethoxynobiletin, and sinensetin suppressed the interleukin 1 (IL-1) induced production of proMMP-9/progelatinase B in rabbit synovial cells in a dose dependent manner (<64 microM); nobiletin most effectively suppressed proMMP-9 production along with the decrease in its mRNA. Nobiletin also reduced IL-1 induced production of PGE2 in the synovial cells, but did not modify the synthesis of total protein. These suppressive effects of nobiletin were also observed in rabbit articular chondrocytes. Nobiletin inhibited proliferation of rabbit synovial fibroblasts in the growth phase.
    CONCLUSIONS:
    These results suggest nobiletin is a novel antiinflammatory candidate that has the potential to inhibit PGE2 production, matrix degradation of the articular cartilage, and pannus formation in osteoarthritis and rheumatoid arthritis. CONCLUSION: These results suggest nobiletin is a novel antiinflammatory candidate that has the potential to inhibit PGE2 production, matrix degradation of the articular cartilage, and pannus formation in osteoarthritis and rheumatoid arthritis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9206 mL 14.6028 mL 29.2056 mL 58.4112 mL 73.014 mL
    5 mM 0.5841 mL 2.9206 mL 5.8411 mL 11.6822 mL 14.6028 mL
    10 mM 0.2921 mL 1.4603 mL 2.9206 mL 5.8411 mL 7.3014 mL
    50 mM 0.0584 mL 0.2921 mL 0.5841 mL 1.1682 mL 1.4603 mL
    100 mM 0.0292 mL 0.146 mL 0.2921 mL 0.5841 mL 0.7301 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:2159513211
    4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin CFN93255 6601-66-7 C19H18O6 = 342.4 5mg QQ客服:2159513211
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:1413575084
    栀子黄素B; Gardenin B CFN93144 2798-20-1 C19H18O7 = 358.4 10mg QQ客服:1457312923
    桔皮素; Tangeretin CFN90240 481-53-8 C20H20O7 = 372.37 20mg QQ客服:1457312923
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 5mg QQ客服:2056216494
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:3257982914
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:1413575084
    黄花夹竹桃黄酮; Thevetiaflavone CFN96124 29376-68-9 C16H12O5 = 284.3 5mg QQ客服:2159513211
    野黄芩素; Scutellarein CFN98557 529-53-3 C15H10O6 = 286.24 20mg QQ客服:2932563308

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