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  • 三裂鼠尾草素

    Salvigenin

    三裂鼠尾草素
    产品编号 CFN99883
    CAS编号 19103-54-9
    分子式 = 分子量 C18H16O6 = 328.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Salvia japonica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三裂鼠尾草素 CFN99883 19103-54-9 1mg QQ客服:1148253675
    三裂鼠尾草素 CFN99883 19103-54-9 5mg QQ客服:1148253675
    三裂鼠尾草素 CFN99883 19103-54-9 10mg QQ客服:1148253675
    三裂鼠尾草素 CFN99883 19103-54-9 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Massachusetts General Hospital (USA)
  • Macau University of Science and Technology (China)
  • University of Sao Paulo (Brazil)
  • Medical University of South Carolina (USA)
  • University of Medicine and Pharmacy (Romania)
  • Universitas islam negeri Jakarta (Indonesia)
  • Srinakharinwirot University (Thailand)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Charles University in Prague (Czech Republic)
  • Universiti Sains Malaysia (Malaysia)
  • University of Pretoria (South Africa)
  • University of Toronto (Canada)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Maryland School of Medicine (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Commun.2014, 9(5):679-82
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Pharm Biol.2016, 54(7):1255-62
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • J Ethnopharmacol.2017, 196:75-83
  • Biol Pharm Bull.2017, 40(6):797-806
  • Viruses.2017, 9(10)
  • Nat Prod Sci.2018, 24(2):109-114
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Arch Biochem Biophys.2018, 644:93-99
  • J Agric Food Chem.2018, 66(1):351-358
  • Nat Commun.2019, 10(1):2745
  • Biomed Pharmacother.2019, 116:108987
  • Chemistry of Plant Materials.2019, 215-222
  • J Ethnopharmacol.2019, 244:112074
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Srinagarind Medical Journal2019, 34(1)
  • J Sep Sci.2019, 42(21):3352-3362
  • J Mol Histol.2019, 50(4):343-354
  • Plant Cell Tiss Org2020, 1-16
  • Molecules2020, 25(4):892
  • Antioxidants (Basel).2020, 9(2): E119
  • ...
  • 生物活性
    Description: Salvigenin, a potent hMAO-A [monoamine oxidases (MAOs)]inhibitor, has neuroprotective, antitumor and immunomodulatory effects, it has potential to ameliorate Streptozotocin-induced diabetes mellitus and heart complications in rats. Salvigenin has dose-dependent analgesic effect so that it can be useful in controlling of inflammations, acute and chronic pain.
    Targets: gp120/CD4 | IL Receptor | Caspase | Bcl-2/Bax | MAO | Immunology & Inflammation related
    In vitro:
    Mol Cell Biochem. 2012 Dec;371(1-2):9-22.
    Increase of autophagy and attenuation of apoptosis by Salvigenin promote survival of SH-SY5Y cells following treatment with H₂O₂.[Pubmed: 22899171]
    Oxidative stress is a major component of harmful cascades activated in neurodegenerative disorders.
    METHODS AND RESULTS:
    Here, we tried to elucidate the possible neuroprotective effect of Salvigenin, a natural polyphenolic compound, on oxidative stress-induced apoptosis and autophagy in human neuroblastoma SH-SY5Y cells. We measured cell viability by MTT test and found that 25 μM is the best protective concentration of Salvigenin. GSH and SOD assays suggested that Salvigenin activates antioxidant factors. At the same time, measurement of ER stress-associated proteins including calpain and caspase-12 showed the ability of Salvigenin to decrease ER stress. We found that Salvigenin could decrease the apoptotic factors. Salvigenin inhibited H(2)O(2)-induced caspase-3 which is a hallmark of apoptosis in addition to reducing Bax\Bcl-2 ratio by 1.45 fold. Additionally, Salvigenin increased the levels of autophagic factors.
    CONCLUSIONS:
    Our results showed an increase in LC3-II/LC3-I ratio, Atg7, and Atg12 in the presence of 25 μM of Salvigenin by about 1.28, 1.25, and 1.54 folds, respectively, compared to H(2)O(2)-treated cells. So it seems that H(2)O(2) cytotoxicity mainly results from apoptosis. Besides, Salvigenin helps cells to survive by inhibiting apoptosis and enhancing autophagy that opens a new horizon for the future experiments.
    In vivo:
    Cell Immunol. 2013 Nov-Dec;286(1-2):16-21.
    Antitumor and immunomodulatory effects of salvigenin on tumor bearing mice.[Pubmed: 24270218]
    Development of agents that specifically kill cancer cells and simultaneously elicit antitumor immune response is a step forward in cancer therapy. Immunostimulation can result in eliminating of the cancer cells; immunotherapy is a promising approach in balancing the immune response by Treg.
    METHODS AND RESULTS:
    In the present study, we investigated whether the administration of salvigenin contributes to the augmentation of antitumor immunity and the regression of tumor tissues in a mouse model of breast cancer. Salvigenin was purified from Tanacetum canescens, and its effect on the tumor volume was investigated. The splenocyte proliferation, shifting of cytokine profile, and the presence of naturally-occurring CD4+CD25+Foxp3+ Treg cells were assessed to describe the anti-tumor immune response.
    CONCLUSIONS:
    Our results demonstrated that a significant decrease in the level of IL-4 and increase in the IFN-γ in the animals treated with salvigenin and significant decreased in the level of splenic CD4+CD25+Foxp3+ T regulatory cells. The cytotoxic and immunomodulatory properties of salvigenin were acknowledged in vivo.
    Advaced Herbal Medicine , 2015, 1(3):31-41.
    Anti-inflammatory and Analgesic Properties of Salvigenin, Salvia officinalis Flavonoid Extracted.[Reference: WebLink]
    Salvigenin is one of the active flavonoids existing in this plant. The aim of this study was to evaluate the anti-inflammatory and analgesic effect of Salvigenin, Salvia officinalis flavonoid extracted.
    METHODS AND RESULTS:
    In this laboratory experimental study, plant was extracted and the column chromatography was used to purify prepared extracts. 100 male albino mice and 48 male wistar rats were selected. In the hot plate test and in the writhing test, animals were divided randomly into 5 groups. Group 1 (received 10 mg/kg normal saline), groups 2, 3 and 4 (received Salvigenin 25, 50 and 100 mg/kg intraperitoneally, espectively), group 5 (received 10 mg/kg morphine in hot plate test and 10 mg/kg indomethacin in writhing test). In the inflammatory test, animals were divided into 6 groups. Group 1 was assigned as a control group which received 0.05 ml of carrageenin. Groups 2, 3 and 4 (received Salvigenin, at doses of 25, 50 and 100 mg/kg). Group 5 (received 10 mg/kg indomethacin) and then changes of the volume of all groups were measured. Data were analyzed using ANOVA and Tukey test and P. In writhing test, Salvigenin reduced the number of abdominal contractions at doses of 50 and 100 mg/kg. Increasing dose of Salvigenin, with reduction in abdominal cramps resulted in the increasing of pain inhibition, and the percentage of this inhibition was statistically significant (P<0.001). In hot plate test, also 30, 45 and 60 minutes after injection of Salvigenin and morphine showed significant difference compared to the control group (P<0.001). Also, Salvigenin increased the maximum percentage of analgesic compared to the control group (P<0.001). Salvigenin could reduce inflammation and in the group that received Salvigenin at 100 mg/kg, the inflammation was significantly lower than the control group (P<0.05).
    CONCLUSIONS:
    Our findings showed that Salvigenin has dose-dependent analgesic effect so that it can be useful in controlling of inflammations, acute and chronic pain.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.046 mL 15.23 mL 30.4599 mL 60.9199 mL 76.1499 mL
    5 mM 0.6092 mL 3.046 mL 6.092 mL 12.184 mL 15.23 mL
    10 mM 0.3046 mL 1.523 mL 3.046 mL 6.092 mL 7.615 mL
    50 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.2184 mL 1.523 mL
    100 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.6092 mL 0.7615 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柳穿鱼黄素; Pectolinarigenin CFN99010 520-12-7 C17H14O6 = 314.3 20mg QQ客服:215959384
    三裂鼠尾草素; Salvigenin CFN99883 19103-54-9 C18H16O6 = 328.3 10mg QQ客服:2932563308
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:1413575084
    4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin CFN93255 6601-66-7 C19H18O6 = 342.4 5mg QQ客服:1413575084
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:2159513211
    栀子黄素B; Gardenin B CFN93144 2798-20-1 C19H18O7 = 358.4 10mg QQ客服:1148253675
    桔皮素; Tangeretin CFN90240 481-53-8 C20H20O7 = 372.37 20mg QQ客服:1148253675
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 5mg QQ客服:3257982914
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:2159513211
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:215959384

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