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    栀子黄素B

    Gardenin B

    栀子黄素B
    产品编号 CFN93144
    CAS编号 2798-20-1
    分子式 = 分子量 C19H18O7 = 358.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The fruits of Gardenia jasminoides Ellis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    栀子黄素B CFN93144 2798-20-1 1mg QQ客服:2159513211
    栀子黄素B CFN93144 2798-20-1 5mg QQ客服:2159513211
    栀子黄素B CFN93144 2798-20-1 10mg QQ客服:2159513211
    栀子黄素B CFN93144 2798-20-1 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Malaysia Pahang (Malaysia)
  • Rio de Janeiro State University (Brazil)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • The University of Newcastle (Australia)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Indian Institute of Science (India)
  • Auburn University (USA)
  • University of Dicle (Turkey)
  • Macau University of Science and Technology (China)
  • University of Zurich (Switzerland)
  • John Innes Centre (United Kingdom)
  • Agricultural Research Organization (ARO) (Israel)
  • Universidad Industrial de Santander (Colombia)
  • University of Hawaii Cancer Center (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Science and Biotechnology2015, 2205-2212
  • University of Limpopo2016, 1-237
  • Phytochem Anal.2016, 27(5):296-303
  • J Agric Food Chem.2016, 64(35):6783-90
  • J Pharm Biomed Anal.2017, 140:274-280
  • Sci Rep. 2017, 17332(7)
  • Molecules.2017, 22(2)
  • Sci Rep. 2018, 1-9
  • Chem Biol Interact.2018, 290:44-51
  • Nat Commun.2019, 10(1):2745
  • Biomed Pharmacother.2019, 116:108987
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • BMC Complement Altern Med.2019, 19(1):325
  • BMC Complement Altern Med.2019, 19(1):367
  • Int J Mol Sci.2019, 20(16):E4015
  • Phytother Res.2019, 33(4):1104-1113
  • Environ Toxicol.2019, 34(4):513-520.
  • Phytother Res.2020, 34(4):788-795.
  • Biology (Basel).2020, 9(11):363.
  • Analytical Letters.2020, doi 10.1008
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • Ulm University Medical Center2020, doi: 10.18725.
  • Chung Shan Medical University2020, US20200323790A1
  • ...
  • 生物活性
    Description: Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species. Gardenin B can strongly inhibit biochemical production of nitric oxide (IC50=10.59±0.4 ug/mL).
    Targets: NO | ROS | Caspase | PARP
    In vitro:
    Chem Biol Interact. 2016 Aug 25;256:220-7.
    Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species.[Pubmed: 27423764 ]
    Flavonoids have attracted great interest due to their possible anticancer activities.
    METHODS AND RESULTS:
    Here we investigated the antiproliferative activity of the flavonoids isolated from Baccharis scandens against human leukemia cell lines and found that the methoxyflavonoid gardenin B was the most cytotoxic compound against HL-60 and U-937 cells, showing IC50 values between 1.6 and 3.0 μM, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. These effects on viability were accompanied by the concentration- and time-dependent appearance of apoptosis as evidenced by DNA fragmentation, formation of apoptotic bodies and a sub-G1 ratio increase. Comparative studies with the best-studied bioflavonoid quercetin indicate that gardenin B is a more cytotoxic and more apoptotic inducer than quercetin. Cell death induced by gardenin B was associated with: (i) a significant induction of caspase-2, -3, -8 and -9 activities; (ii) cleavage of the initiator caspases (caspase-2, -8 and -9), of the executioner caspase-3, and of poly(ADP-ribose) polymerase; and (iii) a concentration-dependent reactive oxygen species generation.
    CONCLUSIONS:
    In conclusion, apoptosis induced by gardenin B is associated with activation of both the extrinsic and the intrinsic apoptotic pathways of cell death and occurs through a mechanism that is independent of the generation of reactive oxygen species.
    Biomed Pharmacother. 2017 Jan;85:444-456.
    Characterization of bioactive constituents from the gum resin of Gardenia lucida and its pharmacological potential.[Pubmed: 27899258 ]

    METHODS AND RESULTS:
    In the present study we mined the information on Gardenia lucida (Dikamali) and identified seven polymethoxyflavones from its gum resin. We also investigated its antiproliferative and antioxidant potential. Xanthomicrol (8) found as potent DPPH scavenger (85.86±1.3%) along with strong ferric plummeting ability (53.60±2.0 FSE) and reducing potential (1.07±0.01) as compared to ascorbic acid. Gardenin B (5) strongly inhibit biochemical production of nitric oxide (IC50 10.59±0.4μg/mL) followed by 5-Desmethylnobiletin (7) and Gardenin E (10, IC5011.01±0.7-34.53±2.7μg/mL). Methanol extract, chloroform fraction and Acerosin (11), Gardenin D (9) and Gardenin B (5) exhibited superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes (IC50 12.82±0.67-94.63±1.27μg/mL) whereas other fractions and isolated compounds moderately affect the cell proliferation (21.40±0.12-48.12±0.47%) with least and non-specific interaction against succinate dehydrogenase. Except compound 2, 3, 6, 8 and 11, others were found as a significant inhibitor of ODC (IC50 2.36±0.7-8.53±0.32μg/mL) with respect to DFMO (IC50 10.85±0.28μg/mL). In silico analysis also revealed enervated binding energy (-4.30 to -5.02kcal/mol) and inhibition constant (704.18-210.26μM) wherein 5, 7, 8, 9 and 10 showed specific interaction with the receptor while rest were non-specific. Except butanol fraction and Gardenin E, others were potently inhibited the cathepsin D activity with non-specific interaction and better binding energy (-5.78 to -7.24kcal/mol) and inhibition constant (57.87-4.90μM).
    CONCLUSIONS:
    In conclusion, it can be interpreted that isolated polymethoxyflavones (Gardenin B, 5-Desmethylnobiletin, Gardenin E) could be taken up as a lead for target specific studies. Methanol extract and chloroform fraction prevails in all the tested activity therefore cumulative and composite intervention of polymethoxyflavones present in it reveals its pharmacological attributes and traditional value.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7902 mL 13.9509 mL 27.9018 mL 55.8036 mL 69.7545 mL
    5 mM 0.558 mL 2.7902 mL 5.5804 mL 11.1607 mL 13.9509 mL
    10 mM 0.279 mL 1.3951 mL 2.7902 mL 5.5804 mL 6.9754 mL
    50 mM 0.0558 mL 0.279 mL 0.558 mL 1.1161 mL 1.3951 mL
    100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.558 mL 0.6975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 5mg QQ客服:1457312923
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:3257982914
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:1457312923
    黄花夹竹桃黄酮; Thevetiaflavone CFN96124 29376-68-9 C16H12O5 = 284.3 5mg QQ客服:1457312923
    野黄芩素; Scutellarein CFN98557 529-53-3 C15H10O6 = 286.24 20mg QQ客服:2056216494
    高车前素; Hispidulin CFN99491 1447-88-7 C16H12O6 = 300.3 20mg QQ客服:1413575084
    蓟黄素; Cirsimaritin CFN97126 6601-62-3 C17H14O6 = 314.3 5mg QQ客服:2932563308
    4'-羟基汉黄芩素; 4'-Hydroxywogonin CFN98960 57096-02-3 C16H12O6 = 300.3 10mg QQ客服:2056216494
    5,8-二羟基-2-(4-羟基苯基)-6,7-二甲氧基-4H- 1-苯并吡喃-4-酮; Isothymusin CFN97562 98755-25-0 C17H14O7 = 330.3 5mg QQ客服:2932563308
    金合欢素; 刺槐素; Acacetin CFN98744 480-44-4 C16H12O5 = 284.3 20mg QQ客服:1457312923

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