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  • 三甲基芹菜素

    Trimethylapigenin

    三甲基芹菜素
    产品编号 CFN91890
    CAS编号 5631-70-9
    分子式 = 分子量 C18H16O5 = 312.32
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria indica L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三甲基芹菜素 CFN91890 5631-70-9 1mg QQ客服:3257982914
    三甲基芹菜素 CFN91890 5631-70-9 5mg QQ客服:3257982914
    三甲基芹菜素 CFN91890 5631-70-9 10mg QQ客服:3257982914
    三甲基芹菜素 CFN91890 5631-70-9 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Illinois (USA)
  • CSIRO - Agriculture Flagship (Australia)
  • Universidade do Porto (Portugal)
  • National Hellenic Research Foundation (Greece)
  • Michigan State University (USA)
  • University of Indonesia (Indonesia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Lund University (Sweden)
  • Chungnam National University (Korea)
  • University of Toulouse (France)
  • University of Otago (New Zealand)
  • Utah State University (USA)
  • University of Queensland (Australia)
  • University of Cincinnati (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:352
  • Sci. Rep.2015, 14-23
  • Auburn University2015, 1-58
  • Tumour Biol.2015, 36(9):7027-34
  • FEBS Lett.2015, 589(1):182-7
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Acta Chromatographica2016, 29(3)
  • Int J Oncol.2016, 49(4):1497-504
  • PLoS One.2017, 12(3):e0173585
  • Int J Mol Sci.2017, 18(12)
  • Int J Anal Chem.2017, 2017:1254721
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • J Nat Med.2017, 71(2):457-462
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Planta Med.2018, 84(6-07):465-474
  • Mol Microbiol.2019, 112(1):317-332
  • Spectrochim Acta A2019, 210:372-380
  • Molecules.2019, 24(22):E4022
  • Food Chem.2019, 279:80-87
  • Phytother Res.2019, 33(3):676-689
  • Academic J of Second Military Medical University2019, 40(1)
  • Br J Pharmacol.2020, 10.1111
  • Evid-Based Compl Alt2020, 7202519:13
  • ...
  • 生物活性
    Description: Trimethyapigenin has anti-inflammatory activity, it can moderately inhibit production of TNF-α. ,iNOS mRNA and iNOS protein in a dose-dependent manner. It may be a potential candidate for anti-atrial fibrillation, it can significantly inhibit the atrial potassium currents hKv1.5/I(Kur) and I(KACh).
    Targets: Potassium Channel | AChR | TNF-α | NO | NOS | ERK | JNK | IkB | MAPK | IKK
    In vitro:
    Biochem Pharmacol. 2012 Aug 15;84(4):498-506.
    Effects of the natural flavone trimethylapigenin on cardiac potassium currents.[Pubmed: 22583923 ]
    The natural flavones and polymethylflavone have been reported to have cardiovascular protective effects.
    METHODS AND RESULTS:
    In the present study, we determined whether quecertin, apigenin and their methylated compounds (3,7,3',4'-tetramethylquecertin, 3,5,7,3',4'-pentamethylquecertin, 7,4'-dimethylapigenin, and 5,7,4'-Trimethylapigenin) would block the atrial specific potassium channel hKv1.5 using a whole-cell patch voltage-clamp technique. We found that only Trimethylapigenin showed a strong inhibitory effect on hKv1.5 channel current. This compound suppressed hKv1.5 current in HEK 293 cell line (IC₅₀=6.4 μM), and the ultra-rapid delayed rectify K⁺ current I(Kur) in human atrial myocytes (IC₅₀=8.0 μM) by binding to the open channels and showed a use- and frequency-dependent manner. In addition, Trimethylapigenin decreased transient outward potassium current (I(to)) in human atrial myocytes, inhibited acetylcholine-activated K⁺ current (IC₅₀=6.8μM) in rat atrial myocytes. Interestingly, Trimethylapigenin had a weak inhibition of hERG channel current.
    CONCLUSIONS:
    Our results indicate that trimethyapigenin significantly inhibits the atrial potassium currents hKv1.5/I(Kur) and I(KACh), which suggests that Trimethylapigenin may be a potential candidate for anti-atrial fibrillation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2018 mL 16.0092 mL 32.0184 mL 64.0369 mL 80.0461 mL
    5 mM 0.6404 mL 3.2018 mL 6.4037 mL 12.8074 mL 16.0092 mL
    10 mM 0.3202 mL 1.6009 mL 3.2018 mL 6.4037 mL 8.0046 mL
    50 mM 0.064 mL 0.3202 mL 0.6404 mL 1.2807 mL 1.6009 mL
    100 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:3257982914
    黄花夹竹桃黄酮; Thevetiaflavone CFN96124 29376-68-9 C16H12O5 = 284.3 5mg QQ客服:2932563308
    野黄芩素; Scutellarein CFN98557 529-53-3 C15H10O6 = 286.24 20mg QQ客服:2159513211
    高车前素; Hispidulin CFN99491 1447-88-7 C16H12O6 = 300.3 20mg QQ客服:215959384
    蓟黄素; Cirsimaritin CFN97126 6601-62-3 C17H14O6 = 314.3 5mg QQ客服:1413575084
    4'-羟基汉黄芩素; 4'-Hydroxywogonin CFN98960 57096-02-3 C16H12O6 = 300.3 10mg QQ客服:2159513211
    5,8-二羟基-2-(4-羟基苯基)-6,7-二甲氧基-4H- 1-苯并吡喃-4-酮; Isothymusin CFN97562 98755-25-0 C17H14O7 = 330.3 5mg QQ客服:215959384
    金合欢素; 刺槐素; Acacetin CFN98744 480-44-4 C16H12O5 = 284.3 20mg QQ客服:3257982914
    5-羟基-4’,7-二甲氧基黄酮; 7,4'-Di-O-methylapigenin CFN98819 5128-44-9 C17H14O5 = 298.3 5mg QQ客服:215959384
    三甲基芹菜素; Trimethylapigenin CFN91890 5631-70-9 C18H16O5 = 312.32 5mg QQ客服:2932563308

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