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  • 柳穿鱼黄素

    Pectolinarigenin

    柳穿鱼黄素
    产品编号 CFN99010
    CAS编号 520-12-7
    分子式 = 分子量 C17H14O6 = 314.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Linaria vulgaris Mill
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    柳穿鱼黄素 CFN99010 520-12-7 10mg QQ客服:1148253675
    柳穿鱼黄素 CFN99010 520-12-7 20mg QQ客服:1148253675
    柳穿鱼黄素 CFN99010 520-12-7 50mg QQ客服:1148253675
    柳穿鱼黄素 CFN99010 520-12-7 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Gdański (Poland)
  • Universidade de Franca (Brazil)
  • University of Minnesota (USA)
  • Aarhus University (Denmark)
  • Mahatma Gandhi University (India)
  • University of Dicle (Turkey)
  • Calcutta University (India)
  • Max Rubner-Institut (MRI) (Germany)
  • University of British Columbia (Canada)
  • Complutense University of Madrid (Spain)
  • Agricultural Research Organization (ARO) (Israel)
  • Copenhagen University (Denmark)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Medical University of Gdansk (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Auburn University2015, 1-58
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Am J Chin Med.2016, 44(8):1719-1735
  • Current Pharmaceutical Analysis2017, 13(5)
  • J Ethnopharmacol.2017, 198:205-213
  • J Ethnopharmacol.2017, 198:91-97
  • Nutrients.2018, 10(7)
  • Exp Parasitol.2018, 194:67-78
  • Korean J of Medicinal Crop Science2018, 220-226
  • Molecules.2018, 23(12):E3103
  • Mol Cells.2018, 41(8):771-780
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Primary and Industrial.2018, 52(11)
  • Toxicol In Vitro.2018, 52:94-105
  • Front Cell Infect Microbiol.2018, 8:292
  • Nat Commun.2019, 10(1):2745
  • Drug Invention Today2019, 12(6):1303-1306
  • Molecules.2019, 24(10):E1930
  • Molecules.2019, 24(16):E3003
  • Nat Prod Sci.2019, 25(3):238
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Phytomedicine.2019, 55:229-237
  • Food Res Int.2020, 128:108778
  • ...
  • 生物活性
    Description: Pectolinarigenin possesses anti-inflammatory, antiallergic and hepatoprotective activities.It is a dual inhibitor of COX-2/5-LOX,and the IC50 >1 microM; it also can increase activity levels of GSH, GR, GCS, and GST, as well as SOD.
    Targets: COX | LOX | SOD
    In vitro:
    Biol Pharm Bull. 2008 Nov;31(11):2063-7.
    Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum.[Pubmed: 18981574]

    CONCLUSIONS:
    In order to identify the active anti-inflammatory ingredient(s) in Cirsium chanroenicum (Compositae), its methanol extract and several solvent fractions were prepared; the methanol extract and the ethylacetate fraction inhibited cyclooxygenase-2 (COX-2)-mediated prostaglandin E2 (PGE2) and 5-lipoxygenase (5-LOX)-mediated leukotriene (LT) production in lipopolysaccharide-treated RAW 264.7 cells and A23187-treated rat basophilic leukemia (RBL-1) cells, respectively. Further bioactivity-guided fractionation of the ethylacetate fraction using column chromatography led to the isolation of pectolinarigenin (5,7-dihydroxy-4',6-dimethoxyflavone), along with pectolinarin [pectolinarigenin 7-rhamnosyl-(1-->6)-glucoside]. Pectolinarigenin strongly inhibited COX-2-mediated PGE2 and 5-LOX-mediated LT production at >1 microM, indicating that it is a dual inhibitor of COX-2/5-LOX. However, pectolinarigenin did not affect COX-2 expression or nuclear transcription factor (NF-kappaB) activation. In addition, in vivo studies demonstrated that oral administration of these two compounds at 20-100 mg/kg resulted in similar inhibitory activities against several animal models of inflammation/allergy: arachidonic acid-induced mouse ear edema, carrageenan-induced mouse paw edema and passive cutaneous anaphylaxis.
    CONCLUSIONS:
    All of these results suggest that pectolinarigenin and pectolinarin possess anti-inflammatory activity and that they may inhibit eicosanoid formation in inflammatory lesions. These activities certainly contribute to the anti-inflammatory mechanism of C. chanroenicum.
    In vivo:
    Evid Based Complement Alternat Med. 2014;2014:828760.
    Inhibitory Effect on β -Hexosaminidase Release from RBL-2H3 Cells of Extracts and Some Pure Constituents of Benchalokawichian, a Thai Herbal Remedy, Used for Allergic Disorders.[Pubmed: 25580152]
    Benchalokawichian (BCW), a Thai traditional herbal formulation, has long been used as antipyretic and to treat skin disorders. It comprises roots from five herbs: Ficus racemosa, Capparis micracantha, Clerodendrum petasites, Harrisonia perforata, and Tiliacora triandra. This polyherbal remedy has recently been included in the Thailand National List of Essential Medicines (Herbal Products list).
    METHODS AND RESULTS:
    A Bioassay-guided fractionation technique was used to evaluate antiallergy activities of crude extracts, and those obtained by the multistep column chromatography isolation of pure compounds. Inhibitory effect on the release of β-hexosaminidase from RBL-2H3 cells was used to determine antiallergic activity. Two pure compounds from BCW formulation showed higher antiallergic activity than crude or semipure extracts. Pectolinarigenin showed the highest antiallergic activity, followed by O-methylalloptaeroxylin, with IC50 values of 6.3 μg/mL and 14.16 μg/mL, respectively. Moreover, the highest activities of pure compounds were significantly higher than chlorpheniramine (16.2 μg/mL).
    CONCLUSIONS:
    This study provides some support for the use of BCW in reducing itching and treatment of other skin allergic disorders. The two isolated constituents exhibited high antiallergic activity and it is necessary to determine their mechanism of action. Further phytochemical and safety studies of pure compounds are required before development of these as antiallergy commercial remedies.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1817 mL 15.9084 mL 31.8167 mL 63.6335 mL 79.5418 mL
    5 mM 0.6363 mL 3.1817 mL 6.3633 mL 12.7267 mL 15.9084 mL
    10 mM 0.3182 mL 1.5908 mL 3.1817 mL 6.3633 mL 7.9542 mL
    50 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.2727 mL 1.5908 mL
    100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6363 mL 0.7954 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    金合欢素; 刺槐素; Acacetin CFN98744 480-44-4 C16H12O5 = 284.3 20mg QQ客服:2932563308
    5-羟基-4’,7-二甲氧基黄酮; 7,4'-Di-O-methylapigenin CFN98819 5128-44-9 C17H14O5 = 298.3 5mg QQ客服:1413575084
    三甲基芹菜素; Trimethylapigenin CFN91890 5631-70-9 C18H16O5 = 312.32 5mg QQ客服:1413575084
    5,6-二羟基-7,4'-二甲氧基黄酮; Ladanein CFN96380 10176-71-3 C17H14O6 = 314.3 5mg QQ客服:215959384
    柳穿鱼黄素; Pectolinarigenin CFN99010 520-12-7 C17H14O6 = 314.3 20mg QQ客服:2932563308
    三裂鼠尾草素; Salvigenin CFN99883 19103-54-9 C18H16O6 = 328.3 10mg QQ客服:3257982914
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:1148253675
    4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin CFN93255 6601-66-7 C19H18O6 = 342.4 5mg QQ客服:215959384
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:3257982914
    栀子黄素B; Gardenin B CFN93144 2798-20-1 C19H18O7 = 358.4 10mg QQ客服:1413575084

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