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  • 芹菜素; 芹黄素; 5,7,4'-三羟基黄酮

    Apigenin

    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮
    产品编号 CFN98843
    CAS编号 520-36-5
    分子式 = 分子量 C15H10O5 = 270.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria indica L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮 CFN98843 520-36-5 10mg QQ客服:215959384
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮 CFN98843 520-36-5 20mg QQ客服:215959384
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮 CFN98843 520-36-5 50mg QQ客服:215959384
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮 CFN98843 520-36-5 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Antioquia (Colombia)
  • University of Cincinnati (USA)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Universidade de Franca (Brazil)
  • Univerzita Karlova v Praze (Czech Republic)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Shanghai University of TCM (China)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Malaya (Malaysia)
  • Uniwersytet Gdański (Poland)
  • Lodz University of Technology (Poland)
  • University of Illinois (USA)
  • University of Medicine and Pharmacy (Romania)
  • University of Maryland School of Medicine (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Br J Pharmacol.2016, 173(2):396-410
  • Nat Prod Sci.2016, 22(2)
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Oncol Rep.2016, 35(3):1356-64
  • Bulletin of Health Research2016, 44(4):279-286
  • Oncotarget.2016, 8(51):88386-88400
  • Polytechnic University of Catalonia2017, 105826
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • J Ethnopharmacol.2017, 209:305-316
  • Phytochemistry Letters2017, 449-455
  • Nat Prod Commun.2018, 10.1177
  • Sci Rep. 2018, 1-9
  • Food Chem.2018, 252:207-214
  • Phytomedicine.2018, 40:37-47
  • Nat Commun.2019, 10(1):5169
  • Nutrients.2019, 12(1):E40
  • J Pharm Biomed Anal.2019, 172:268-277
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Journal of Third Military Medical University2019, 41(2):110-115
  • Appl Biol Chem2019, 62:46
  • Br J Pharmacol.2020, 10.1111
  • Plant Growth Regulation2020, 90(2):383-392
  • ...
  • 生物活性
    Description: Apigenin is a potent inhibitor of CYP2C9, which has anti-inflammatory, antiangiogenic, and anti-cancer effects, it may inhibit EV71 replication through suppressing viral IRES activity and modulating cellular JNK pathway.
    Targets: GSK-3 | TNF-α | IL Receptor | Akt | ROS | JNK | TGF-β/Smad | VEGFR | FAK | Src | CYP2C9
    In vitro:
    Antiviral Res. 2014 Sep;109:30-41.
    Apigenin inhibits enterovirus 71 replication through suppressing viral IRES activity and modulating cellular JNK pathway.[Pubmed: 24971492]
    Enterovirus 71 (EV71) is a member of genus Enterovirus in Picornaviridae family, which is one of the major causative agents for hand, foot and mouth disease (HFMD), and sometimes associated with severe central nervous system diseases in children. Currently there are no effective therapeutic medicines or vaccines for the disease.
    METHODS AND RESULTS:
    In this report, we found that apigenin and luteolin, two flavones that differ only in the number of hydroxyl groups could inhibit EV71-mediated cytopathogenic effect (CPE) and EV71 replication with low cytotoxicity. Both molecules also showed inhibitory effect on the viral polyprotein expression. They prevented EV71-induced cell apoptosis, intracellular reactive oxygen species (ROS) generation and cytokines up-regulation. Time-of-drug addition study demonstrated that apigenin and luteolin acted after viral entry. We examined the effect of apigenin and luteolin on 2A(pro) and 3C(pro) activity, two viral proteases responsible for viral polyprotein processing, and found that they showed less inhibitory activity on 2A(pro) or 3C(pro). Further studies demonstrated that apigenin, but not luteolin could interfere with viral IRES activity. Also, apigenin inhibited EV71-induced c-Jun N-terminal kinase (JNK) activation which is critical for viral replication, in contrast to luteolin that did not.
    CONCLUSIONS:
    This study demonstrated that apigenin may inhibit EV71 replication through suppressing viral IRES activity and modulating cellular JNK pathway. It also provided evidence that one hydroxyl group difference in the B ring between apigenin and luteolin resulted in the distinct antiviral mechanisms. This study will provide the basis for better drug development and further identification of potential drug targets.
    In vivo:
    Br J Nutr. 2015 Feb 28;113(4):618-26.
    Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium.[Pubmed: 25654996]
    Flavonoids are polyphenolic compounds that are widespread in nature, and consumed as part of the human diet in significant amounts. The aim of the present study was to test the intestinal anti-inflammatory activity of apigenin K, a soluble form of apigenin, in two models of rat colitis, namely the trinitrobenzenesulfonic acid (TNBS) model and the dextran sulphate sodium (DSS) model.
    METHODS AND RESULTS:
    Apigenin K (1, 3 and 10 mg/kg; by the oral route; n 4-6 per group) was administered as a pre-treatment to rats with TNBS and DSS colitis, and colonic status was checked by macroscopic and biochemical examination. Apigenin K pre-treatment resulted in the amelioration of morphological signs and biochemical markers in the TNBS model. The results demonstrated a reduction in the inflamed area, as well as lower values of score and colonic weight:length ratio compared with the TNBS group. Myeloperoxidase (MPO) activity was reduced by 30 % (P< 0·05). Moreover, apigenin K pre-treatment ameliorated morphological signs and biochemical markers in the DSS model. Thus, macroscopic damage was significantly reduced and the colonic weight:length ratio was lowered by approximately 10 %, while colonic MPO and alkaline phosphatase activities were decreased by 35 and 21 %, respectively (P< 0·05). Apigenin K pre-treatment also tended to normalise the expression of a number of colonic inflammatory markers (e.g. TNF-α, transforming growth factor-β, IL-6, intercellular adhesion molecule 1 or chemokine (C-C motif) ligand 2).
    CONCLUSIONS:
    In conclusion, apigenin K is found to have anti-inflammatory effects in two preclinical models of inflammatory bowel disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.701 mL 18.5048 mL 37.0096 mL 74.0192 mL 92.5241 mL
    5 mM 0.7402 mL 3.701 mL 7.4019 mL 14.8038 mL 18.5048 mL
    10 mM 0.3701 mL 1.8505 mL 3.701 mL 7.4019 mL 9.2524 mL
    50 mM 0.074 mL 0.3701 mL 0.7402 mL 1.4804 mL 1.8505 mL
    100 mM 0.037 mL 0.185 mL 0.3701 mL 0.7402 mL 0.9252 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    三甲基芹菜素; Trimethylapigenin CFN91890 5631-70-9 C18H16O5 = 312.32 5mg QQ客服:1148253675
    5,6-二羟基-7,4'-二甲氧基黄酮; Ladanein CFN96380 10176-71-3 C17H14O6 = 314.3 5mg QQ客服:2932563308
    柳穿鱼黄素; Pectolinarigenin CFN99010 520-12-7 C17H14O6 = 314.3 20mg QQ客服:3257982914
    三裂鼠尾草素; Salvigenin CFN99883 19103-54-9 C18H16O6 = 328.3 10mg QQ客服:2932563308
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:1148253675
    4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin CFN93255 6601-66-7 C19H18O6 = 342.4 5mg QQ客服:3257982914
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:215959384
    栀子黄素B; Gardenin B CFN93144 2798-20-1 C19H18O7 = 358.4 10mg QQ客服:3257982914
    桔皮素; Tangeretin CFN90240 481-53-8 C20H20O7 = 372.37 20mg QQ客服:1148253675
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 5mg QQ客服:1148253675

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