| Vopr Med Khim. 1986 Sep-Oct;32(5):24-8. |
| Comparative study of the effect of ecdysterone, turkesterone and nerobol on the function of rat liver mitochondria in experimental diabetes[Pubmed: 3776112 ] |
METHODS AND RESULTS:
Oxidative phosphorylation and Ca2+-transport functions of liver mitochondria were normalized in rats with alloxane diabetes after peroral administration of phytoecdisteroids - ecdisterone and Turkesterone (5 mg/kg) or nerobol (10 mg/kg) within 15 days.
CONCLUSIONS:
These drugs normalized the activity of NADH dehydrogenase and succinate dehydrogenase in respiratory chain of mitochondria, increased distinctly stability of the enzymes to the effect of such factors as heating, effect of phospholipase A2 or trypsin. |
| Pharm.Chem. J., 2010, 44(1):7-9. |
| Immunomodulating and antistress activity of ecdysterone and turkesterone under immobilization-induced stress conditions in mice.[Reference: WebLink] |
METHODS AND RESULTS:
The phytoecdysteroids ecdysterone and turkesterone isolated from Rhaponticum integrifolium and Ajuga turkestanica herbs, respectively, increase the adaptation capacity of mice under immobilization-induced stress conditions. These compounds prevent involution of the thymicolymphatic system, decrease trophic disorders in gastric mucosa, prevent an increase in the weight of adrenal glands and a decrease in them of the content of ascorbic acid and cholesterol (to a much greater degree than does T-activin), and stimulate immunogenesis in animals with experimental immune deficiency developed on the background of immobilization-induced stress. Key wordsecdysterone-turkesterone-T-activin-immobilization-induced stress-immobilization. |
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