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  • 4β-羟基胆固醇

    4-Beta-Hydroxycholesterol

    4β-羟基胆固醇
    产品编号 CFN90611
    CAS编号 17320-10-4
    分子式 = 分子量 C27H46O2 = 402.66
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源
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    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4β-羟基胆固醇 CFN90611 17320-10-4 1mg QQ客服:3257982914
    4β-羟基胆固醇 CFN90611 17320-10-4 5mg QQ客服:3257982914
    4β-羟基胆固醇 CFN90611 17320-10-4 10mg QQ客服:3257982914
    4β-羟基胆固醇 CFN90611 17320-10-4 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Bordeaux (France)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Medizinische Universit?t Wien (Austria)
  • University of Amsterdam (Netherlands)
  • Universidade Católica Portuguesa (Portugal)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • J Med Food.2021, 24(2):151-160.
  • Drug Test Anal.2018, 10(10):1579-1589
  • Exp Parasitol.2017, 183:160-166
  • Natural Product Communications2021, 16(9):1-10.
  • Anal Chim Acta.2021, 1180:338874.
  • Processes2021, 9(11),2065.
  • Pathogens.2018, 7(3):E62
  • J Ethnopharmacol.2020, 249:112381
  • Int J Mol Sci.2020, 21(19):7209.
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • Foods.2021, 10(6):1378.
  • Front Pharmacol.2022, 13:919230.
  • FASEB J.2019, 33(8):9685-9694
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Integr Med Res.2021, 10(3):100723.
  • Nutrients2022, 14(14)2929
  • Cell Rep.2020, 32(11):108158.
  • Antioxidants (Basel).2020, 9(6):466.
  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • Anal Chim Acta.2018, 1039:162-171
  • Antioxidants (Basel).2021, 10(11): 1802.
  • BMC Complement Altern Med.2019, 19(1):11
  • ...
  • 生物活性
    Description: 4-Beta-hydroxycholesterol is a new endogenous CYP3A marker. 4-Beta-Hydroxycholesterol has exceptionally slow elimination and high plasma concentration properties, may it is a potential role of 4-Beta-Hydroxycholesterol as a ligand for the nuclear.
    Targets: P450 (e.g. CYP17) | Liver X Receptor
    In vivo:
    J Biol Chem. 2002 Aug 30;277(35):31534-40.
    Metabolism of 4 beta -hydroxycholesterol in humans.[Pubmed: 12077124]
    One of the major oxysterols in the human circulation is 4-Beta-Hydroxycholesterol formed from cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4.
    METHODS AND RESULTS:
    Deuterium-labeled 4-Beta-Hydroxycholesterol was injected into two healthy volunteers, and the apparent half-life was found to be 64 and 60 h, respectively. We have determined earlier the half-lives for 7 alpha-, 27-, and 24-hydroxycholesterol to be approximately 0.5, 0.75, and 14 h, respectively. Patients treated with certain antiepileptic drugs have up to 20-fold increased plasma concentrations of 4-Beta-Hydroxycholesterol. The apparent half-life of deuterium-labeled 4-Beta-Hydroxycholesterol in such a patient was found to be 52 h, suggesting that the high plasma concentration was because of increased synthesis rather than impaired clearance. 4-Beta-Hydroxycholesterol was converted into acidic products at a much slower rate than 7 alpha-hydroxycholesterol in primary human hepatocytes, and 4-Beta-Hydroxycholesterol was 7 alpha-hydroxylated at a slower rate than cholesterol by recombinant human CYP7A1. CYP7B1 and CYP39A1 had no activity toward 4-Beta-Hydroxycholesterol.
    CONCLUSIONS:
    These results suggest that the high plasma concentration of 4-Beta-Hydroxycholesterol is because of its exceptionally slow elimination, probably in part because of the low rate of 7 alpha-hydroxylation of the steroid. The findings are discussed in relation to a potential role of 4-Beta-Hydroxycholesterol as a ligand for the nuclear receptor LXR.
    J Biol Chem. 2001 Oct 19;276(42):38685-9.
    Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.[Pubmed: 11514559 ]
    The major cholesterol oxidation products in the human circulation are 27-hydroxycholesterol, 24-hydroxycholesterol, and 7alpha-hydroxycholesterol. These oxysterols are formed from cholesterol by specific cytochrome P450 enzymes, CYP27, CYP46, and CYP7A, respectively. An additional oxysterol present in concentrations comparable with 7alpha- and 24-hydroxycholesterol is 4-Beta-Hydroxycholesterol.
    METHODS AND RESULTS:
    We now report that patients treated with the antiepileptic drugs phenobarbital, carbamazepine, or phenytoin have highly elevated levels of plasma 4-Beta-Hydroxycholesterol. When patients with uncomplicated cholesterol gallstone disease were treated with ursodeoxycholic acid, plasma 4-Beta-Hydroxycholesterol increased by 45%. Ursodeoxycholic acid, as well as the antiepileptic drugs, are known to induce cytochrome P450 3A. Recombinant CYP3A4 was shown to convert cholesterol to 4beta-hydroxycholesterol, whereas no conversion was observed with CYP1A2, CYP2C9, or CYP2B6. The concentration of 4-alpha-hydroxycholesterol in plasma was lower than the concentration of 4beta-hydroxycholesterol and not affected by treatment with the antiepileptic drugs or ursodeoxycholic acid.
    CONCLUSIONS:
    Together, these data suggest that 4-Beta-Hydroxycholesterol in human circulation is formed by a cytochrome P450 enzyme.
    Pharmacogenet Genomics. 2008 Mar;18(3):201-8.
    4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.[Pubmed: 18300941]
    To study the potential endogenous marker of CYP3A activity, 4-Beta-Hydroxycholesterol, and its relation to sex and the CYP3A5 geno/haplotypes and compare with CYP3A4/5 catalyzed 3-hydroxylation of quinine in the three major races.
    METHODS AND RESULTS:
    The plasma concentration of 4-Beta-Hydroxycholesterol was measured in healthy Tanzanians (n=138), Swedes (n=161) and Koreans (n=149) by gas chromatography-mass spectrometry. The metabolic ratio of quinine/3-hydroxyquinine in plasma 16-h post dose was determined by high performance liquid chromatography, previously reported in Tanzanians and Swedes, and now also in Koreans. The participants were genotyped for relevant alleles of CYP3A5. Clear differences in the activity of both CYP3A4 and CYP3A5 were shown in the three major human races. Both 4-Beta-Hydroxycholesterol and quinine/3-hydroxyquinine metabolic ratio showed a higher CYP3A activity in women than in men.
    CONCLUSIONS:
    The results give strong evidence that the plasma concentration of 4-Beta-Hydroxycholesterol may be used as an endogenous marker of CYP3A activity (CYP3A4+5).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4835 mL 12.4174 mL 24.8348 mL 49.6697 mL 62.0871 mL
    5 mM 0.4967 mL 2.4835 mL 4.967 mL 9.9339 mL 12.4174 mL
    10 mM 0.2483 mL 1.2417 mL 2.4835 mL 4.967 mL 6.2087 mL
    50 mM 0.0497 mL 0.2483 mL 0.4967 mL 0.9934 mL 1.2417 mL
    100 mM 0.0248 mL 0.1242 mL 0.2483 mL 0.4967 mL 0.6209 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    维生素D3; Vitamin D3 CFN90027 67-97-0 C27H44O = 384.64 20mg QQ客服:215959384
    维生素D2; Ergocalciferol CFN90049 50-14-6 C28H44O = 396.65 20mg QQ客服:1457312923
    二氢胆固醇; Dihydrocholesterol CFN90608 80-97-7 C27H48O = 388.67 20mg QQ客服:3257982914
    胆固醇; 胆甾醇; Cholesterol CFN90040 57-88-5 C27H46O = 386.67 20mg QQ客服:215959384
    4β-羟基胆固醇; 4-Beta-Hydroxycholesterol CFN90611 17320-10-4 C27H46O2 = 402.66 5mg QQ客服:1457312923
    7β-羟基胆固醇; 7Beta-Hydroxycholesterol CFN90610 566-27-8 C27H46O2 = 402.65 5mg QQ客服:1413575084
    7-酮基胆固醇; 7-Ketocholesterol CFN91812 566-28-9 C27H44O2 = 400.6 5mg QQ客服:1457312923
    7-氧胆固醇乙酯; 7-Oxocholesteryl acetate CFN91647 809-51-8 C29H46O3 = 442.7 5mg QQ客服:1457312923
    27-羟基胆固醇; 27-Hydroxycholesterol CFN90609 20380-11-4 C27H46O2 = 402.65 10mg QQ客服:215959384
    胆甾-4,6-二烯-3-醇; Cholest-4,6-diene-3-ol CFN91582 14214-69-8 C27H44O = 384.6 5mg QQ客服:2159513211

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