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  • 二氢胆固醇

    Dihydrocholesterol

    二氢胆固醇
    产品编号 CFN90608
    CAS编号 80-97-7
    分子式 = 分子量 C27H48O = 388.67
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The testes of White Carneau pigeons.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢胆固醇 CFN90608 80-97-7 10mg QQ客服:2056216494
    二氢胆固醇 CFN90608 80-97-7 20mg QQ客服:2056216494
    二氢胆固醇 CFN90608 80-97-7 50mg QQ客服:2056216494
    二氢胆固醇 CFN90608 80-97-7 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Shanghai Institute of Organic Chemistry (China)
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  • Biotech R&D Institute (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta horticulturae2017, 1158:257-268
  • J Biochem Mol Toxicol.2021, 35(5):e22731.
  • J Nat Med.2020, 74(3):550-560.
  • Asian Pac J Cancer Prev.2021, 22(S1):97-106.
  • Oncotarget.2017, 8(64):108006-108019
  • Front Cell Dev Biol.2021, 9:588093.
  • Onco Targets Ther.2017, 10:3467-3474
  • J Ethnopharmacol.2017, 206:327-336
  • Green Chemistry2021, ISSUE 2.
  • Cancers (Basel).2021, 13(9):2223.
  • LWT2021, 150:112021.
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • PLoS One.2020, 15(2):e0220084.
  • LWT-Food Sci Technol2020, 109163
  • Acta Chromatographica2021, 00960.
  • Plant Methods.2017, 13:108
  • Oncol Rep.2021, 46(1):143.
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Journal of Apiculture2019, 34(2):131-136
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Int J Mol Sci.2020, 21(6):2190.
  • Evid Based Complement Alternat Med.2022, 9767292,2.
  • International Food Research Journal2018, 25(6):2560-2571
  • ...
  • 生物活性
    Description: Dihydrocholesterol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. Dihydrocholesterol is equally effective in reducing plasma cholesterol as β-sitosterol at a low dose, which is mediated by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.
    In vivo:
    Br J Exp Pathol. 1979 Jun;60(3):231-8.
    Dihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury.[Pubmed: 383127]
    Rabbits fed a diet containing 0.75% dihydrocholesterol for 7 days develop bile acid allodeoxycholic (ADCA) and deoxycholic acid (DCA) stones in the gallbladder.
    METHODS AND RESULTS:
    In this model, inflammatory changes in the gallbladder mucosa are often observed even before stones are formed. Within 3 days of the lithogenic diet, abnormalities of platelet function were detectable. Platelet aggregation upon addition of adenosine diphosphate (ADP) was impaired. At the same time the red cells became crenated and developed thorny spicules (echinocytes). This morphological changes was associated with intracellular dehydration and excessive loss of potassium. These changes coincided with a rise in serum ADCA and DCA and preceded a slow rise in serum cholesterol. In vitro incubation studies also suggested that the bile acids had probably caused membrane injury to the platelets and red cells.
    CONCLUSIONS:
    It is concluded that changes in the bile ADCA and DCA probably induce gallbladder epithelial injury in this model of experimental cholelithiasis.
    Atherosclerosis. 2015 Sep;242(1):77-86.
    Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters.[Pubmed: 26184696 ]
    Cholesterol analogs have been used to treat hypercholesterolemia. The present study was to examine the effect of Dihydrocholesterol (DC) on plasma total cholesterol (TC) compared with that of β-sitosterol (SI) in hamsters fed a high cholesterol diet.
    METHODS AND RESULTS:
    Forty-five male hamsters were randomly divided into 6 groups, fed either a non-cholesterol diet (NCD) or one of five high-cholesterol diets without addition of DC and SI (HCD) or with addition of 0.2% DC (DA), 0.3% DC (DB), 0.2% SI (SA), and 0.3% SI (SB), respectively, for 6 weeks. Results showed that DC added into diet at a dose of 0.2% could reduce plasma TC by 21%, comparable to that of SI (19%). At a higher dose of 0.3%, DC reduced plasma TC by 15%, less effective than SI (32%). Both DC and SI could increase the excretion of fecal sterols, however, DC was more effective in increasing the excretion of neutral sterols but it was less effective in increasing the excretion of acidic sterols compared with SI. Results on the incorporation of sterols in micellar solutions clearly demonstrated both DC and SI could displace the cholesterol from micelles with the former being more effective than the latter.
    CONCLUSIONS:
    DC was equally effective in reducing plasma cholesterol as SI at a low dose. Plasma TC-lowering activity of DC was mediated by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5729 mL 12.8644 mL 25.7288 mL 51.4575 mL 64.3219 mL
    5 mM 0.5146 mL 2.5729 mL 5.1458 mL 10.2915 mL 12.8644 mL
    10 mM 0.2573 mL 1.2864 mL 2.5729 mL 5.1458 mL 6.4322 mL
    50 mM 0.0515 mL 0.2573 mL 0.5146 mL 1.0292 mL 1.2864 mL
    100 mM 0.0257 mL 0.1286 mL 0.2573 mL 0.5146 mL 0.6432 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    胆固醇; 胆甾醇; Cholesterol CFN90040 57-88-5 C27H46O = 386.67 20mg QQ客服:3257982914
    4β-羟基胆固醇; 4-Beta-Hydroxycholesterol CFN90611 17320-10-4 C27H46O2 = 402.66 5mg QQ客服:1457312923
    7β-羟基胆固醇; 7Beta-Hydroxycholesterol CFN90610 566-27-8 C27H46O2 = 402.65 5mg QQ客服:1457312923
    7-酮基胆固醇; 7-Ketocholesterol CFN91812 566-28-9 C27H44O2 = 400.6 5mg QQ客服:215959384
    7-氧胆固醇乙酯; 7-Oxocholesteryl acetate CFN91647 809-51-8 C29H46O3 = 442.7 5mg QQ客服:1457312923
    27-羟基胆固醇; 27-Hydroxycholesterol CFN90609 20380-11-4 C27H46O2 = 402.65 10mg QQ客服:2056216494
    胆甾-4,6-二烯-3-醇; Cholest-4,6-diene-3-ol CFN91582 14214-69-8 C27H44O = 384.6 5mg QQ客服:2056216494
    松甾酮A; Ponasterone A CFN99419 13408-56-5 C27H44O6 = 464.6 5mg QQ客服:1413575084
    筋骨草甾酮C; Ajugasterone C CFN90616 23044-80-6 C27H44O7 = 480.64 5mg QQ客服:215959384
    牛膝甾酮; Inokosterone CFN92515 15130-85-5 C27H44O7 = 480.6 5mg QQ客服:1413575084

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