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  • 台湾高黄酮 A

    Taiwanhomoflavone A

    台湾高黄酮 A
    产品编号 CFN96541
    CAS编号 265120-00-1
    分子式 = 分子量 C33H24O10 = 580.55
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The stems of Cephalotaxus wilsoniana.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    台湾高黄酮 A CFN96541 265120-00-1 1mg QQ客服:2159513211
    台湾高黄酮 A CFN96541 265120-00-1 5mg QQ客服:2159513211
    台湾高黄酮 A CFN96541 265120-00-1 10mg QQ客服:2159513211
    台湾高黄酮 A CFN96541 265120-00-1 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Worcester Polytechnic Institute (USA)
  • University of South Australia (Australia)
  • Mahatma Gandhi University (India)
  • Universitas Airlangga (Indonesia)
  • Universidad de La Salle (Mexico)
  • University of Padjajaran (Indonesia)
  • Regional Crop Research Institute (Korea)
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  • Universidad Veracuzana (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian J Beauty Cosmetol2022, 20(2):183-191
  • Chemistry of Plant Materials.2016, 33-46
  • Acta Chromatographica2016, 29(3)
  • Drug Des Devel Ther.2020, 14:61-71
  • Molecules.2016, 21(6)
  • Molecules2020, 25(4):892
  • Research Square2021, 10.21203.
  • Heliyon2020, 6(6):e04337.
  • J Pharm Pharmacol.2022, rgac033.
  • Eur J Pharmacol.2020, 889:173589.
  • Ind Crops Prod.2015, 67:185-191
  • Food Control2022, 132:108434.
  • Metabolites2023, 13(1), 3.
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • J Agric Food Chem.2016, 64(35):6783-90
  • Asian Pac J Tropical Bio.2020, 10(6):239-247
  • Cancers (Basel).2021, 13(17):4327.
  • South African Journal of Botany2021, 142:114-123.
  • Appl. Sci. 2021, 11(8),3437.
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  • ...
  • 生物活性
    Description: Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.
    Targets: COX
    In vitro:
    Chem Pharm Bull (Tokyo). 2000 Mar;48(3):440-1.
    A novel cytotoxic C-methylated biflavone from the stem of Cephalotaxus wilsoniana.[Pubmed: 10726874]

    METHODS AND RESULTS:
    Bioassay-directed fractionation of an ethanolic extract of Cephalotaxus wilsoniana has resulted in the isolation of a novel C-methylated biflavone, taiwanhomoflavone A (1). Its structure was elucidated on the basis of spectroscopic analysis.
    CONCLUSIONS:
    Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.
    Int J Mol Sci. 2007 Aug; 8(8): 830–841.
    Antiplatelet Effect and Selective Binding to Cyclooxygenase (COX) by Molecular Docking Analysis of Flavonoids and Lignans.[Reference: WebLink]
    The known flavonoids ginkgetin (1), Taiwanhomoflavone A (2), taiwanhomoflavone B (3), and taiwanhomoflavone C (4) and eight known lignans: justicidin B (9), justicidin C (10), justicidin D (11), chinensinaphthol methyl ether (12), procumphthalide A (13), procumbenoside A (15), and ciliatosides A (16) and B (17) were isolated from Cephalotaxus wilsoniana and Justicia species, respectively.
    METHODS AND RESULTS:
    The antiplatelet effects of the above constituents on human platelet-rich plasma (PRP) were evaluated. Of the compounds tested on human PRP, compounds 1, 4, 9, and 11 showed inhibition of secondary aggregation induced by adrenaline. Compound 1 had an inhibitory effect on cyclooxygenase-1 (COX-1). Molecular docking studies revealed that 1 and the related compounds apigenin (5), cycloheterophyllin (6), broussoflavone F (7), and quercetin (8) were docked near the gate of active site of COX-1.
    CONCLUSIONS:
    It indicated that the antiplatelet effect of 1, 4, 9, and 11 is partially owed to suppression of COX-1 activity and reduced thromboxane formation. Flavonoids, 1, 5, 6, 7, and 8 may block the gate of the active site of COX-1 and interfere the conversion of arachidonic acid to prostaglandin (PG) H2 in the COX-1 active site.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7225 mL 8.6125 mL 17.225 mL 34.4501 mL 43.0626 mL
    5 mM 0.3445 mL 1.7225 mL 3.445 mL 6.89 mL 8.6125 mL
    10 mM 0.1723 mL 0.8613 mL 1.7225 mL 3.445 mL 4.3063 mL
    50 mM 0.0345 mL 0.1723 mL 0.3445 mL 0.689 mL 0.8613 mL
    100 mM 0.0172 mL 0.0861 mL 0.1723 mL 0.3445 mL 0.4306 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    GB 1b; GB 1b CFN89091 19360-72-6 C30H22O10 = 542.49 5mg QQ客服:1413575084
    GB 2a; GB 2a CFN89133 18412-96-9 C30H22O11 = 558.49 5mg QQ客服:215959384
    荛花醇A; Wikstrol A CFN92960 159736-35-3 C30H22O10 = 542.49 5mg QQ客服:3257982914
    柏木双黄酮; Cupressuflavone CFN70356 3952-18-9 C30H18O10 = 538.5 5mg QQ客服:1413575084
    4',4'''-双-O-甲基姜黄素; 4',4'''-Di-O-methylcupressuflavone CFN97224 74336-91-7 C32H22O10 = 566.5 5mg QQ客服:215959384
    8,8''-二黄芩素; 8,8''-Bibaicalein CFN95007 135309-02-3 C30H18O10 = 538.5 5mg QQ客服:2159513211
    Acuminatanol; Acuminatanol CFN96555 948884-38-6 C30H22O16 = 638.49 5mg QQ客服:2056216494
    2,3-Dihydroamentoflavone 7,4'-dimethyl ether; 2,3-Dihydroamentoflavone 7,4'-dimethyl ether CFN96163 873999-88-3 C32H24O10 = 568.5 5mg QQ客服:215959384
    2,3-二羟基三叶橡胶黄酮; 2,3-Dihydroheveaflavone CFN96119 110382-42-8 C33H26O10 = 582.6 5mg QQ客服:1457312923
    2,3-二羟基金松双黄酮; 2,3-dihydrosciadopitysin CFN96134 34421-19-7 C33H26O10 = 582.6 5mg QQ客服:1413575084

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