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  • 金松双黄酮

    Sciadopitysin

    金松双黄酮
    产品编号 CFN98847
    CAS编号 521-34-6
    分子式 = 分子量 C33H24O10 = 580.6
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Ginkgo biloba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    金松双黄酮 CFN98847 521-34-6 10mg QQ客服:2159513211
    金松双黄酮 CFN98847 521-34-6 20mg QQ客服:2159513211
    金松双黄酮 CFN98847 521-34-6 50mg QQ客服:2159513211
    金松双黄酮 CFN98847 521-34-6 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Fribourg (Switzerland)
  • VIT University (India)
  • University of Medicine and Pharmacy (Romania)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Siksha O Anusandhan University (India)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Sapienza University of Rome (Italy)
  • University of Mysore (India)
  • Kyung Hee University (Korea)
  • Calcutta University (India)
  • National Hellenic Research Foundation (Greece)
  • Seoul National University of Science and Technology (Korea)
  • Universidad Industrial de Santander (Colombia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Separation Science Plus2022, sscp.202200048.
  • Biomol Ther (Seoul).2019, 10.4062
  • Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
  • J Cachexia Sarcopenia Muscle.2022, 13(6):3149-3162.
  • Molecules.2021, 26(9):2791.
  • Int J Mol Sci.2020, 21(24):9369.
  • Primary and Industrial.2018, 52(11)
  • Enzyme Microb Technol.2019, 122:64-73
  • Mie University2019, 10076.
  • Front Pharmacol.2021, 12:765521.
  • J Agric Food Chem.2020, 68(43):12164-12172.
  • Neuropharmacology.2018, 131:68-82
  • Plant Pathology2022, 13527
  • Research on Crops.2017, 18(2)
  • Synthetic and Systems Biotechnology2023, j.synbio.
  • LWT2021, 147:111620.
  • Int J Mol Med.2016, 37(2):501-8
  • Analytical Methods2018, 10(27)
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Antioxidants (Basel).2021, 10(10):1638.
  • Industrial Crops and Products2020, 146:112186
  • Nutrients.2021, 13(3):978.
  • Toxicol In Vitro.2019, 59:161-178
  • ...
  • 生物活性
    Description: Sciadopitysin shows protective effects on antimycin A-induced toxicity in osteoblastic MC3T3-E1 cells, it may reduce or prevent osteoblasts degeneration; it also may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis. Sciadopitysin can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.
    Targets: ROS | MMP(e.g.TIMP) | NO | TNF-α | ATPase | cAMP | Beta Amyloid
    In vitro:
    Free Radic Res. 2014 Jul;48(7):729-39.
    Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis.[Pubmed: 24628445]
    Methylglyoxal (MG) is a precursor of advanced glycation end products, which contribute to diabetic complications, including bone defects.
    METHODS AND RESULTS:
    In the present study, the effect of Sciadopitysin on MG-induced cytotoxicity was investigated using osteoblastic MC3T3-E1 cells. Pretreatment of MC3T3-E1 cells with Sciadopitysin prevented the MG-induced cell death and protein adducts formation. Sciadopitysin restored the MG-induced change in glyoxalase activity almost to the control level and increased glutathione levels. In addition, Sciadopitysin decreased MG-induced formation of intracellular reactive oxygen species (ROS), mitochondrial superoxide, and cardiolipin peroxidation. These findings suggest that Sciadopitysin provides a protective action against MG-induced glycation by increasing MG detoxification system and by reducing oxidative stress. Pretreatment with Sciadopitysin prior to MG exposure reduced MG-induced mitochondrial dysfunction by preventing mitochondrial membrane potential (MMP) dissipation and adenosine triphosphate (ATP) loss. The nitric oxide (NO) level was decreased by MG treatment, but it was significantly increased by Sciadopitysin, suggesting that Sciadopitysin may induce NO-dependent mitochondrial biogenesis. Furthermore, Sciadopitysin treatment increased the levels of sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), nuclear respiratory factor 1 (NRF-1), and mitochondrial transcription factor A (TFAM).
    CONCLUSIONS:
    These findings indicate that Sciadopitysin might exert its therapeutic effects via upregulation of mitochondrial biogenesis. Therefore, Sciadopitysin may prevent the development of diabetic osteopathy.
    Nat Prod Res. 2013;27(22):2157-60.
    Sciadopitysin: active component from Taxus chinensis for anti-Alzheimer's disease.[Pubmed: 23627438]

    METHODS AND RESULTS:
    Five taxane diterpenoids derived from the 95% ethanol extract of Taxus chinensis were tested for the inhibitory activities on amyloid-beta (Aβ) peptide aggregation. Using thioflavin-T fluorescence assay, sciadopitysin was found to exhibit the most potency against Aβ aggregation and the formation of fibrils. Further cellular assay indicated that sciadopitysin increased the cell viability of SH-SY5Y cell and demonstrated neuroprotection against Aβ protein-induced insult in primary cortical neurons.
    CONCLUSIONS:
    According to the authors' best knowledge, this is the first report that sciadopitysin can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7224 mL 8.6118 mL 17.2236 mL 34.4471 mL 43.0589 mL
    5 mM 0.3445 mL 1.7224 mL 3.4447 mL 6.8894 mL 8.6118 mL
    10 mM 0.1722 mL 0.8612 mL 1.7224 mL 3.4447 mL 4.3059 mL
    50 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.6889 mL 0.8612 mL
    100 mM 0.0172 mL 0.0861 mL 0.1722 mL 0.3445 mL 0.4306 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4',4'''-双-O-甲基姜黄素; 4',4'''-Di-O-methylcupressuflavone CFN97224 74336-91-7 C32H22O10 = 566.5 5mg QQ客服:3257982914
    8,8''-二黄芩素; 8,8''-Bibaicalein CFN95007 135309-02-3 C30H18O10 = 538.5 5mg QQ客服:2159513211
    Acuminatanol; Acuminatanol CFN96555 948884-38-6 C30H22O16 = 638.49 5mg QQ客服:2056216494
    2,3-Dihydroamentoflavone 7,4'-dimethyl ether; 2,3-Dihydroamentoflavone 7,4'-dimethyl ether CFN96163 873999-88-3 C32H24O10 = 568.5 5mg QQ客服:1457312923
    2,3-二羟基三叶橡胶黄酮; 2,3-Dihydroheveaflavone CFN96119 110382-42-8 C33H26O10 = 582.6 5mg QQ客服:215959384
    2,3-二羟基金松双黄酮; 2,3-dihydrosciadopitysin CFN96134 34421-19-7 C33H26O10 = 582.6 5mg QQ客服:2159513211
    2,3-二氢罗汉松黄酮A; 2,3-Dihydropodocarpusflavone A CFN96378 852875-96-8 C31H22O10 = 554.5 5mg QQ客服:215959384
    四氢阿曼托黄素; Tetrahydroamentoflavone CFN98755 48236-96-0 C30H22O10 = 542.5 5mg QQ客服:1457312923
    3',3'''-二柚皮素; 3',3'''-Binaringenin CFN95558 145399-99-1 C30H22O10 = 542.5 5mg QQ客服:1413575084
    穗花杉双黄酮; 阿曼托黄酮; Amentoflavone CFN99526 1617-53-4 C30H18O10 = 538.46 20mg QQ客服:215959384

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