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  • 吴茱萸苦素

    Rutaevin

    吴茱萸苦素
    产品编号 CFN96685
    CAS编号 33237-37-5
    分子式 = 分子量 C26H30O9 = 486.51
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The root barks of Dictamnus dasycarpus.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    吴茱萸苦素 CFN96685 33237-37-5 10mg QQ客服:215959384
    吴茱萸苦素 CFN96685 33237-37-5 20mg QQ客服:215959384
    吴茱萸苦素 CFN96685 33237-37-5 50mg QQ客服:215959384
    吴茱萸苦素 CFN96685 33237-37-5 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Lodz (Poland)
  • Northeast Normal University Changchun (China)
  • The Australian National University (Australia)
  • Gyeongsang National University (Korea)
  • Kyung Hee University (Korea)
  • Heidelberg University (Germany)
  • Cornell University (USA)
  • Harvard University (USA)
  • Nanjing University of Chinese Medicine (China)
  • The Institute of Cancer Research (United Kingdom)
  • Universite Libre de Bruxelles (Belgium)
  • Kazusa DNA Research Institute (Japan)
  • Colorado State University (USA)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • Pharmacia2022, 69(3): 883-890.
  • Pharm Biol.2021, 59(1):134-145.
  • Mol Med Rep.2022, 25(1):8.
  • Biochem Biophys Res Commun.2020, 530(1):4-9.
  • J Nat Prod.2019, 82(4):1002-1008
  • Plants (Basel).2021, 10(12):2795.
  • Biomolecules.2023, 13(2):227.
  • J Ginseng Res.2022, 46(1):104-114.
  • J Cell Mol Med . 2023, jcmm.17954.
  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.
  • Planta Med.2019, 85(3):217-224
  • TCI CO.2019, US20190151257A1
  • Biomol Ther (Seoul).2019, 10.4062
  • Appl. Sci. 2021, 11(8),3437.
  • Plant Physiol Biochem.2023, 202:107913.
  • Exp Mol Med.2020, 52(4):629-642.
  • Front Pharmacol.2018, 9:236
  • Antioxidants.2022, 11(3):491.
  • Front Pharmacol.2022, 13:906763.
  • Biochem Systematics and Ecology2017, 11-18
  • Eur J Pharmacol.2021, 906:174220.
  • Front Pharmacol.2016, 7:460
  • ...
  • 生物活性
    Description: Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.
    Targets: NO
    In vitro:
    J. Asian Nat. Prod. Res.,2013;15(10):1130-8.
    Limonoid constituents of Euodia rutaecarpa var. bodinieri and their inhibition on NO production in lipopolysaccharide-activated RAW264.7 macrophages.[Pubmed: 23869424 ]

    METHODS AND RESULTS:
    A new limonoid compound, named evorubodinin (1), was isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang (family Rutaceae), together with two known limonoid compounds, limonin (2) and evolimorutanin (3). The chemical structure of 1 was elucidated by spectroscopic method and single-crystal X-ray diffraction. The inhibitory effects of the isolated compounds 1-3 and the structurally related compounds evodol (4), shihulimonin A1 (5), evodirutaenin (6), 12α-hydroxyRutaevin (7), and Rutaevin (8) on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages were also assayed.
    CONCLUSIONS:
    All compounds 1-8 showed the inhibitory activity, in which both 7 and 8 with the uncommon 5β-H configuration more efficiently inhibited NO production. The results provided valuable information for further investigation of compounds 1-8 as anti-inflammatory agents or lead compounds.
    Chem. Biodivers.,2017 Mar;14(3)
    Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation.[Pubmed: 27797447 ]

    METHODS AND RESULTS:
    One new chromone 3,3-dimethylallylspatheliachromene methyl ether (1), as well as five known chromones, 6-(3-methylbut-2-enyl) allopteroxylin methyl ether (2), 6-(3-methylbut-2-enyl) allopteroxylin (3), 3,3-dimethylallylspatheliachromene (4), 5-O-methylcneorumchromone K (5) and spatheliabischromene (6), two alkaloids, 8-methoxy-N-methylflindersine (7) and 8-methoxyflindersine (8), and two limonoids, limonin diosphenol (9) and rutaevin (10), were isolated from Dictyoloma vandellianum A. Juss (Rutaceae). Cytotoxic activities towards tumor cell lines B16-F10, HepG2, K562 and HL60 and non-tumor cells PBMC were evaluated for compounds 1 - 6.
    CONCLUSIONS:
    Compound 1 was the most active showing IC50 values ranging from 6.26 to 14.82 μg/ml in B16-F10 and K562 cell lines, respectively, and presented IC50 value of 11.65 μg/ml in PBMC cell line.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0555 mL 10.2773 mL 20.5546 mL 41.1091 mL 51.3864 mL
    5 mM 0.4111 mL 2.0555 mL 4.1109 mL 8.2218 mL 10.2773 mL
    10 mM 0.2055 mL 1.0277 mL 2.0555 mL 4.1109 mL 5.1386 mL
    50 mM 0.0411 mL 0.2055 mL 0.4111 mL 0.8222 mL 1.0277 mL
    100 mM 0.0206 mL 0.1028 mL 0.2055 mL 0.4111 mL 0.5139 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柠檬酸; Limonexic acid CFN97565 99026-99-0 C26H30O10 = 502.5 5mg QQ客服:2056216494
    Isolimonexic acid; Isolimonexic acid CFN96839 73904-93-5 C26H30O10 = 502.51 5mg QQ客服:2159513211
    Limonol; Limonol CFN97564 989-61-7 C26H32O8 = 472.5 5mg QQ客服:1457312923
    柠檬苦素; Limonin CFN99280 1180-71-8 C26H30O8 = 470.5 20mg QQ客服:1457312923
    海罂粟碱B; Glaucin B CFN99256 115458-73-6 C28H32O10 = 528.6 5mg QQ客服:2056216494
    吴茱萸苦素; Rutaevin CFN96685 33237-37-5 C26H30O9 = 486.51 20mg QQ客服:215959384
    吴茱萸苦素 7-乙酯; Rutaevin 7-acetate CFN91983 62306-81-4 C28H32O10 = 528.55 5mg QQ客服:2056216494
    吴茱萸醇; Evodol CFN98214 22318-10-1 C26H28O9 = 484.5 5mg QQ客服:3257982914
    12alpha-羟基吴茱萸醇; 12alpha-Hydroxyevodol CFN99328 120722-04-5 C26H28O10 = 500.5 5mg QQ客服:1413575084

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