Info: Read More
  • 中药标准品生产商,产品定制服务
  • 柠檬酸

    Limonexic acid

    柠檬酸
    产品编号 CFN97565
    CAS编号 99026-99-0
    分子式 = 分子量 C26H30O10 = 502.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruits of Evodia rutaecarpa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柠檬酸 CFN97565 99026-99-0 1mg QQ客服:1457312923
    柠檬酸 CFN97565 99026-99-0 5mg QQ客服:1457312923
    柠檬酸 CFN97565 99026-99-0 10mg QQ客服:1457312923
    柠檬酸 CFN97565 99026-99-0 20mg QQ客服:1457312923
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of East Anglia (United Kingdom)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Toronto (Canada)
  • Wroclaw Medical University (Poland)
  • University of Liège (Belgium)
  • Technical University of Denmark (Denmark)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Yale University (USA)
  • Monash University Sunway Campus (Malaysia)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Amity University (India)
  • Shanghai Institute of Organic Chemistry (China)
  • Mendel University in Brno (Czech Republic)
  • Kazusa DNA Research Institute (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Molecular Liquids2021, 334:116014.
  • Vietnam J. Chemistry2022, 60(2):211-222
  • BMC Plant Biol.2022, 22(1):128.
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Front Pharmacol.2016, 7:460
  • Plant Physiol Biochem.2023, 201:107795.
  • Anat Rec2018, 24264
  • Applied Biological Chemistry2021, 64(4)
  • Int Immunopharmacol.2020, 90:107268.
  • Molecules2022, 27(12):3824.
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Saudi Pharm J2020, 10.1016
  • Acta Physiologiae Plantarum2016, 38:7
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • Reprod Toxicol.2020, 96:1-10.
  • Heliyon.2023, 9:e21652.
  • Biomolecules2021, 11(10),1513.
  • Food Chem.2023, 404(Pt A):134517.
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Int J Pharm.2022, 618:121636.
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • ...
  • 生物活性
    Description: Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte against CCl4-induced injury.
    Targets: GABA Receptor
    In vitro:
    Food Chem Toxicol. 2013 Dec;62:432-5.
    Protective effect of compounds from the flowers of Citrus aurantium L. var. amara Engl against carbon tetrachloride-induced hepatocyte injury.[Pubmed: 23985451]
    5-Hydroxy-6,7,3',4'-tetramethoxyflavone (HTF), Limonexic acid (LA) are two compounds isolated from the flowers of Citrus aurantium L. var. amara Engl with various biological activities.
    METHODS AND RESULTS:
    This study was designed to investigate their protective effects against carbon tetrachloride (CCl4)-induced hepatocyte injury, using human hepatic cell line HL-7702 to determine the cell cytotoxicity, cell viability, levels of hepatic marker enzymes, malondialdehyde (MDA). Results showed that pretreatment with HTF, Limonexic acid could significantly reverse CCl4-induced HL-7702 cell viability decrease, Limonexic acid displayed a higher activity. HTF, Limonexic acid also showed their capability of decreasing the CCl4-induced leakage of lactate dehydrogenase (LDH), aspartate aminotransferase (AST), inhibiting the lipid peroxidation, HTF showed more significant activity.
    CONCLUSIONS:
    Given that HTF, Limonexic acid were not toxic, it is concluded that HTF, Limonexic acid could effectively protect hepatocyte against CCl4-induced injury.
    In vivo:
    J Pharm Pharmacol. 2007 Nov;59(11):1573-81.
    Antinociceptive action of limonexic acid obtained from Raulinoa echinata.[Pubmed: 17976270]
    The antinociceptive effect of the Limonexic acid isolate of Raulinoa echinata Cowan in four models of pain in mice is described.
    METHODS AND RESULTS:
    When evaluated against acetic acid-induced abdominal constrictions, Limonexic acid (10, 30 and 60 mg kg(-1), i.p.) produced dose-related inhibition of the number of constrictions, with a mean ID50 value of 43 (2.3-79) micromol kg(-1), and was more potent than some standard drugs. In the formalin test, Limonexic acid inhibited both the first and second phases of formalin-induced pain. Furthermore, the effect was more pronounced in the second phase, with a mean ID50 value of 13.66 (9.35-19.61) micromol kg(-1), and had a pharmacological profile that was similar to standard drugs such as acetaminophen and acetyl salicylic acid. Limonexic acid also produced dose-related inhibition of glutamate- and capsaicin-induced pain, with mean ID50 values of 11.67 (8.51-16.0) micromol kg(-1) and 47.17 (36.51-60.93) micromol kg(-1), respectively.
    CONCLUSIONS:
    The mechanism of action is not completely understood, but seems to involve direct interaction with the GABAergic and nitroxidergic pathways.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.99 mL 9.9502 mL 19.9005 mL 39.801 mL 49.7512 mL
    5 mM 0.398 mL 1.99 mL 3.9801 mL 7.9602 mL 9.9502 mL
    10 mM 0.199 mL 0.995 mL 1.99 mL 3.9801 mL 4.9751 mL
    50 mM 0.0398 mL 0.199 mL 0.398 mL 0.796 mL 0.995 mL
    100 mM 0.0199 mL 0.0995 mL 0.199 mL 0.398 mL 0.4975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柠檬酸; Limonexic acid CFN97565 99026-99-0 C26H30O10 = 502.5 5mg QQ客服:1413575084
    Isolimonexic acid; Isolimonexic acid CFN96839 73904-93-5 C26H30O10 = 502.51 5mg QQ客服:1413575084
    Limonol; Limonol CFN97564 989-61-7 C26H32O8 = 472.5 5mg QQ客服:2159513211
    柠檬苦素; Limonin CFN99280 1180-71-8 C26H30O8 = 470.5 20mg QQ客服:2056216494
    海罂粟碱B; Glaucin B CFN99256 115458-73-6 C28H32O10 = 528.6 5mg QQ客服:1457312923
    吴茱萸苦素; Rutaevin CFN96685 33237-37-5 C26H30O9 = 486.51 20mg QQ客服:2056216494
    吴茱萸苦素 7-乙酯; Rutaevin 7-acetate CFN91983 62306-81-4 C28H32O10 = 528.55 5mg QQ客服:2159513211
    吴茱萸醇; Evodol CFN98214 22318-10-1 C26H28O9 = 484.5 5mg QQ客服:215959384
    12alpha-羟基吴茱萸醇; 12alpha-Hydroxyevodol CFN99328 120722-04-5 C26H28O10 = 500.5 5mg QQ客服:2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产