柠檬酸

Limonexic acid

	产品编号	CFN97565
	CAS编号	99026-99-0
	分子式 = 分子量	C₂₆H₃₀O₁₀ = 502.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The fruits of Evodia rutaecarpa
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
柠檬酸	CFN97565	99026-99-0	1mg	QQ客服：1413575084
柠檬酸	CFN97565	99026-99-0	5mg	QQ客服：1413575084
柠檬酸	CFN97565	99026-99-0	10mg	QQ客服：1413575084
柠檬酸	CFN97565	99026-99-0	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Ioannina (Greece)

University of Parma (Italy)

University of Padjajaran (Indonesia)

Gyeongsang National University (Korea)

Ateneo de Manila University (Philippines)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

University of Perugia (Italy)

Melbourne University (Australia)

Siksha O Anusandhan University (India)

University of Melbourne (Australia)

Leibniz Institute of Plant Biochemistry (Germany)

Tokyo Woman's Christian University (Japan)

University of Stirling (United Kingdom)

Universidade Católica Portuguesa (Portugal)

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Description:

Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte against CCl4-induced injury.

Targets:

GABA Receptor

In vitro:

Food Chem Toxicol. 2013 Dec;62:432-5.

Protective effect of compounds from the flowers of Citrus aurantium L. var. amara Engl against carbon tetrachloride-induced hepatocyte injury.[Pubmed: 23985451]

5-Hydroxy-6,7,3',4'-tetramethoxyflavone (HTF), Limonexic acid (LA) are two compounds isolated from the flowers of Citrus aurantium L. var. amara Engl with various biological activities.
METHODS AND RESULTS:
This study was designed to investigate their protective effects against carbon tetrachloride (CCl4)-induced hepatocyte injury, using human hepatic cell line HL-7702 to determine the cell cytotoxicity, cell viability, levels of hepatic marker enzymes, malondialdehyde (MDA). Results showed that pretreatment with HTF, Limonexic acid could significantly reverse CCl4-induced HL-7702 cell viability decrease, Limonexic acid displayed a higher activity. HTF, Limonexic acid also showed their capability of decreasing the CCl4-induced leakage of lactate dehydrogenase (LDH), aspartate aminotransferase (AST), inhibiting the lipid peroxidation, HTF showed more significant activity.
CONCLUSIONS:
Given that HTF, Limonexic acid were not toxic, it is concluded that HTF, Limonexic acid could effectively protect hepatocyte against CCl4-induced injury.

In vivo:

J Pharm Pharmacol. 2007 Nov;59(11):1573-81.

Antinociceptive action of limonexic acid obtained from Raulinoa echinata.[Pubmed: 17976270]

The antinociceptive effect of the Limonexic acid isolate of Raulinoa echinata Cowan in four models of pain in mice is described.
METHODS AND RESULTS:
When evaluated against acetic acid-induced abdominal constrictions, Limonexic acid (10, 30 and 60 mg kg(-1), i.p.) produced dose-related inhibition of the number of constrictions, with a mean ID50 value of 43 (2.3-79) micromol kg(-1), and was more potent than some standard drugs. In the formalin test, Limonexic acid inhibited both the first and second phases of formalin-induced pain. Furthermore, the effect was more pronounced in the second phase, with a mean ID50 value of 13.66 (9.35-19.61) micromol kg(-1), and had a pharmacological profile that was similar to standard drugs such as acetaminophen and acetyl salicylic acid. Limonexic acid also produced dose-related inhibition of glutamate- and capsaicin-induced pain, with mean ID50 values of 11.67 (8.51-16.0) micromol kg(-1) and 47.17 (36.51-60.93) micromol kg(-1), respectively.
CONCLUSIONS:
The mechanism of action is not completely understood, but seems to involve direct interaction with the GABAergic and nitroxidergic pathways.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
柠檬酸; Limonexic acid	CFN97565	99026-99-0	C₂₆H₃₀O₁₀ = 502.5	5mg	QQ客服：215959384
Isolimonexic acid; Isolimonexic acid	CFN96839	73904-93-5	C₂₆H₃₀O₁₀ = 502.51	5mg	QQ客服：1457312923
Limonol; Limonol	CFN97564	989-61-7	C₂₆H₃₂O₈ = 472.5	5mg	QQ客服：3257982914
柠檬苦素; Limonin	CFN99280	1180-71-8	C₂₆H₃₀O₈ = 470.5	20mg	QQ客服：215959384
脱氧柠檬苦素; Desoxylimonin	CFN91424	989-23-1	C₂₆H₃₀O₇ = 454.5	5mg	QQ客服：215959384
海罂粟碱B; Glaucin B	CFN99256	115458-73-6	C₂₈H₃₂O₁₀ = 528.6	5mg	QQ客服：215959384
吴茱萸苦素; Rutaevin	CFN96685	33237-37-5	C₂₆H₃₀O₉ = 486.51	20mg	QQ客服：2159513211
吴茱萸苦素 7-乙酯; Rutaevin 7-acetate	CFN91983	62306-81-4	C₂₈H₃₂O₁₀ = 528.55	5mg	QQ客服：1457312923
吴茱萸醇; Evodol	CFN98214	22318-10-1	C₂₆H₂₈O₉ = 484.5	5mg	QQ客服：215959384
12alpha-羟基吴茱萸醇; 12alpha-Hydroxyevodol	CFN99328	120722-04-5	C₂₆H₂₈O₁₀ = 500.5	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.99 mL	9.9502 mL	19.9005 mL	39.801 mL	49.7512 mL
5 mM	0.398 mL	1.99 mL	3.9801 mL	7.9602 mL	9.9502 mL
10 mM	0.199 mL	0.995 mL	1.99 mL	3.9801 mL	4.9751 mL
50 mM	0.0398 mL	0.199 mL	0.398 mL	0.796 mL	0.995 mL
100 mM	0.0199 mL	0.0995 mL	0.199 mL	0.398 mL	0.4975 mL

柠檬酸

Limonexic acid

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