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  • Limonol

    Limonol

    Limonol
    产品编号 CFN97564
    CAS编号 989-61-7
    分子式 = 分子量 C26H32O8 = 472.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The barks of Melia azedarach L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Limonol CFN97564 989-61-7 1mg QQ客服:215959384
    Limonol CFN97564 989-61-7 5mg QQ客服:215959384
    Limonol CFN97564 989-61-7 10mg QQ客服:215959384
    Limonol CFN97564 989-61-7 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Ioannina (Greece)
  • Seoul National University of Science and Technology (Korea)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Stanford University (USA)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Donald Danforth Plant Science Center (USA)
  • University of Canterbury (New Zealand)
  • Sanford Burnham Medical Research Institute (USA)
  • Universidade Federal de Santa Catarina (Brazil)
  • Tohoku University (Japan)
  • University of Wollongong (Australia)
  • Calcutta University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Key Engineering Materials2022, 931(47-53).
  • Plant Foods Hum Nutr.2020, 10.1007
  • Phytother Res.2019, 33(5):1490-1500
  • Foods2023, 12(23), 4342.
  • Int J Mol Sci.2021, 22(19):10220.
  • Food Chem.2019, 275:746-753
  • Molecules.2022, 27(2):451.
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • Kasetsart University2022, ethesis.1144.
  • Int J Mol Sci.2019, 20(16):E4015
  • Antiviral Res.2021, 193:105142.
  • J of Dentistry & Oral Health2019, 2641-1962
  • Anal Bioanal Chem. 2016, 408(15)
  • Appl. Sci.2023, 13(17), 9653.
  • J. Food Composition and Analysis2022, 114:104731
  • Metabolites2022, 12(6),507.
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Int J Mol Sci.2020, 21(8):2790.
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • Molecules.2020, 25(21):5087.
  • Anal Sci.2019, 35(12):1317-1325
  • Biomol Ther (Seoul).2023, 31(1):40-47.
  • ...
  • 生物活性
    Description: Limonol-derivatives could as promising scaffolds for the design of novel Hsp90α inhibitors.
    Targets: Raf | ATPase | Akt | HSP (e.g. HSP90)
    In vitro:
    Fitoterapia. 2000 Jun;71(3):317-20.
    Antifungal activity of some tetranortriterpenoids.[Pubmed: 10844171]

    METHODS AND RESULTS:
    Natural tetranortriterpenoids such as cedrelone from Toona ciliata, azadiradione from Azadirachta indica, limonin, Limonol and nomilinic acid from Citrus medica, along with some cedrelone derivatives were tested for their antifungal activity against Puccinia arachidis, a groundnut rust pathogen. Results show that cedrelone was the most effective in reducing rust pustule emergence.
    CONCLUSIONS:
    Replacement of functional groups or modification of the A or the B ring in cedrelone reduced the effectiveness indicating the importance of specific structural features for activity.
    Chemistry. 2016 Sep 5;22(37):13236-50.
    Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach.[Pubmed: 27492719 ]
    The identification of inhibitors of Hsp90 is currently a primary goal in the development of more effective drugs for the treatment of various types of multidrug resistant malignancies.
    METHODS AND RESULTS:
    In an attempt to identify new small molecules modulating the activity of Hsp90, we screened a small library of tetranortriterpenes. A high-affinity interaction with Hsp90 inducible form was uncovered for eight of these compounds, five of which are described here for the first time. By monitoring the ATPase activity and the citrate synthase thermal induced aggregation, compound 1 (cedrelosin A), 3 (7α-limonylacetate), and 5 (cedrelosin B), containing a Limonol moiety, were found to be the most effective in compromising the Hsp90α chaperone activity. Consistent with these findings, the three compounds caused a depletion of c-Raf and pAkt Hsp90 client proteins in HeLa and MCF/7 cell lines. Induced fit docking protocol and molecular dynamics were used to rationalize the structural basis of the biological activity of the Limonol derivatives.
    CONCLUSIONS:
    Taken together, these results point to Limonol-derivatives as promising scaffolds for the design of novel Hsp90α inhibitors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1164 mL 10.582 mL 21.164 mL 42.328 mL 52.9101 mL
    5 mM 0.4233 mL 2.1164 mL 4.2328 mL 8.4656 mL 10.582 mL
    10 mM 0.2116 mL 1.0582 mL 2.1164 mL 4.2328 mL 5.291 mL
    50 mM 0.0423 mL 0.2116 mL 0.4233 mL 0.8466 mL 1.0582 mL
    100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4233 mL 0.5291 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柠檬酸; Limonexic acid CFN97565 99026-99-0 C26H30O10 = 502.5 5mg QQ客服:3257982914
    Isolimonexic acid; Isolimonexic acid CFN96839 73904-93-5 C26H30O10 = 502.51 5mg QQ客服:2159513211
    Limonol; Limonol CFN97564 989-61-7 C26H32O8 = 472.5 5mg QQ客服:1457312923
    柠檬苦素; Limonin CFN99280 1180-71-8 C26H30O8 = 470.5 20mg QQ客服:1457312923
    海罂粟碱B; Glaucin B CFN99256 115458-73-6 C28H32O10 = 528.6 5mg QQ客服:1413575084
    吴茱萸苦素; Rutaevin CFN96685 33237-37-5 C26H30O9 = 486.51 20mg QQ客服:2056216494
    吴茱萸苦素 7-乙酯; Rutaevin 7-acetate CFN91983 62306-81-4 C28H32O10 = 528.55 5mg QQ客服:1457312923
    吴茱萸醇; Evodol CFN98214 22318-10-1 C26H28O9 = 484.5 5mg QQ客服:2159513211
    12alpha-羟基吴茱萸醇; 12alpha-Hydroxyevodol CFN99328 120722-04-5 C26H28O10 = 500.5 5mg QQ客服:1413575084

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