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  • 吴茱萸醇

    Evodol

    吴茱萸醇
    产品编号 CFN98214
    CAS编号 22318-10-1
    分子式 = 分子量 C26H28O9 = 484.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruits of Evodia rutaecarpa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    吴茱萸醇 CFN98214 22318-10-1 1mg QQ客服:1457312923
    吴茱萸醇 CFN98214 22318-10-1 5mg QQ客服:1457312923
    吴茱萸醇 CFN98214 22318-10-1 10mg QQ客服:1457312923
    吴茱萸醇 CFN98214 22318-10-1 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Massachusetts General Hospital (USA)
  • Universidade Católica Portuguesa (Portugal)
  • Mendel University in Brno (Czech Republic)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Toulouse (France)
  • University of East Anglia (United Kingdom)
  • Utah State University (USA)
  • University of Eastern Finland (Finland)
  • Hamdard University (India)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Semmelweis Unicersity (Hungary)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Kazusa DNA Research Institute (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2020, 2020:2584783.
  • Wageningen University & Research2018, January 2018
  • Sci Rep.2017, 7(1):3249
  • Chem Biol Interact.2018, 290:44-51
  • Saudi Pharm J.2019, 27(1):145-153
  • Appl. Sci. 2021, 11(17),7829
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Int J Mol Med.2019, 43(6):2516-2522
  • PLoS One.2015, 10(5):e0127060
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Kangwon National University2022, 37(1):29-37
  • Planta Med.2023, a-2192-2281.
  • J Pharm Biomed Anal.2019, 172:268-277
  • Biomedicines.2021, 9(8):996.
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Anticancer Res.2018, 38(4):2127-2135
  • Korean J of Medicinal Crop Science2018, 220-226
  • Applied Biological Chemistry2023, 66(58):112.
  • Appl. Sci. 2021, 11(22), 10552
  • Journal of Functional Foods2021, 84:104581
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • Molecules.2023, 28(16):6025.
  • Molecules.2022, 27(7):2360.
  • ...
  • 生物活性
    Description: Evodol may as an anti-inflammatory agent or lead compound, it shows inhibitory activity on nitric oxide (NO) production in lipopolysaccharide -activated RAW264.7 macrophages. Evodol and limonin possess larvicidal activity against the Asian tiger mosquitoes with LC50 values of 52.22 and 32.43 ug/ml, respectively.
    Targets: NO
    In vitro:
    J Asian Nat Prod Res. 2013;15(10):1130-8.
    Limonoid constituents of Euodia rutaecarpa var. bodinieri and their inhibition on NO production in lipopolysaccharide-activated RAW264.7 macrophages.[Pubmed: 23869424 ]

    METHODS AND RESULTS:
    A new limonoid compound, named evorubodinin (1), was isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang (family Rutaceae), together with two known limonoid compounds, limonin (2) and evolimorutanin (3). The chemical structure of 1 was elucidated by spectroscopic method and single-crystal X-ray diffraction. The inhibitory effects of the isolated compounds 1-3 and the structurally related compounds Evodol (4), shihulimonin A1 (5), evodirutaenin (6), 12α-hydroxyrutaevin (7), and rutaevin (8) on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages were also assayed.
    CONCLUSIONS:
    All compounds 1-8 showed the inhibitory activity, in which both 7 and 8 with the uncommon 5β-H configuration more efficiently inhibited NO production. The results provided valuable information for further investigation of compounds 1-8 as anti-inflammatory agents or lead compounds.
    In vivo:
    Parasitol Res. 2012 Sep;111(3):991-6.
    Mosquito larvicidal activity of alkaloids and limonoids derived from Evodia rutaecarpa unripe fruits against Aedes albopictus (Diptera: Culicidae).[Pubmed: 22526296]

    METHODS AND RESULTS:
    Bioactivity-directed chromatographic separation of chloroform extract on repeated silica gel columns led to the isolation of three alkaloids (evodiamine, rutaecarpine, and wuchuyuamide I) and two limonoids (Evodol and limonin). The structures of the constituent compounds were elucidated based on high-resolution electron impact mass spectrometry and nuclear magnetic resonance. Evodiamine, rutaecarpine, and wuchuyuamide I exhibited strong larvicidal activity against the early fourth instar larvae of A. albopictus with LC(50) values of 12.51, 17.02, and 26.16 μg/ml, respectively. Limonin and Evodol also possessed larvicidal activity against the Asian tiger mosquitoes with LC(50) values of 32.43 and 52.22 μg/ml, respectively, while the ethanol extract had a LC(50) value of 43.21 μg/ml.
    CONCLUSIONS:
    The results indicated that the ethanol extract of E. rutaecarpa and the five isolated constituents have a good potential as a source for natural larvicides.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.064 mL 10.3199 mL 20.6398 mL 41.2797 mL 51.5996 mL
    5 mM 0.4128 mL 2.064 mL 4.128 mL 8.2559 mL 10.3199 mL
    10 mM 0.2064 mL 1.032 mL 2.064 mL 4.128 mL 5.16 mL
    50 mM 0.0413 mL 0.2064 mL 0.4128 mL 0.8256 mL 1.032 mL
    100 mM 0.0206 mL 0.1032 mL 0.2064 mL 0.4128 mL 0.516 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柠檬酸; Limonexic acid CFN97565 99026-99-0 C26H30O10 = 502.5 5mg QQ客服:1457312923
    Isolimonexic acid; Isolimonexic acid CFN96839 73904-93-5 C26H30O10 = 502.51 5mg QQ客服:3257982914
    Limonol; Limonol CFN97564 989-61-7 C26H32O8 = 472.5 5mg QQ客服:215959384
    柠檬苦素; Limonin CFN99280 1180-71-8 C26H30O8 = 470.5 20mg QQ客服:2159513211
    海罂粟碱B; Glaucin B CFN99256 115458-73-6 C28H32O10 = 528.6 5mg QQ客服:1457312923
    吴茱萸苦素; Rutaevin CFN96685 33237-37-5 C26H30O9 = 486.51 20mg QQ客服:2159513211
    吴茱萸苦素 7-乙酯; Rutaevin 7-acetate CFN91983 62306-81-4 C28H32O10 = 528.55 5mg QQ客服:1457312923
    吴茱萸醇; Evodol CFN98214 22318-10-1 C26H28O9 = 484.5 5mg QQ客服:2056216494
    12alpha-羟基吴茱萸醇; 12alpha-Hydroxyevodol CFN99328 120722-04-5 C26H28O10 = 500.5 5mg QQ客服:1457312923

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