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  • 柠檬苦素

    Limonin

    柠檬苦素
    产品编号 CFN99280
    CAS编号 1180-71-8
    分子式 = 分子量 C26H30O8 = 470.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The peels of Citrus maxima.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柠檬苦素 CFN99280 1180-71-8 10mg QQ客服:2159513211
    柠檬苦素 CFN99280 1180-71-8 20mg QQ客服:2159513211
    柠檬苦素 CFN99280 1180-71-8 50mg QQ客服:2159513211
    柠檬苦素 CFN99280 1180-71-8 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Toronto (Canada)
  • University of Ioannina (Greece)
  • Pennsylvania State University (USA)
  • University of Mysore (India)
  • Chungnam National University (Korea)
  • Universidad de Buenos Aires (Argentina)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Chiang Mai University (Thailand)
  • University of Illinois at Chicago (USA)
  • University of Canterbury (New Zealand)
  • University of East Anglia (United Kingdom)
  • Univerzita Karlova v Praze (Czech Republic)
  • Donald Danforth Plant Science Center (USA)
  • Universidade da Beira Interior (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • ACS Nano.2018, 12(4):3385-3396
  • Toxicol Mech Methods.2021, 1-12.
  • J Appl Toxicol.2020, 40(7):965-978.
  • Primary and Industrial.2018, 52(11)
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Eur J Pharmacol.2021, 899:174010.
  • SCOPUS.2020, 836-847.
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • PLoS One.2018, 13(4):e0195642
  • ACS Omega2020, 5,33,20825-20830
  • University of Limpopo2016, 1-237
  • Phytomedicine2022, 104:154337.
  • Int J Oncol.2019, 55(1):320-330
  • Tissue Cell.2022, 75:101728.
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Phytomedicine2022, 104:154318
  • Phytother Res.2022, 35844057.
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • J Pharm Pharmacol.2022, rgac033.
  • ...
  • 生物活性
    Description: Limonin is a widely used dietary supplement, one of the most prevalent citrus limonoids, which has antioxidant, anti-inflammatory, anticancer and anti-human immunodeficiency virus(HIV)activity. It induced a down regulation of TLR-2 ,TLR-4,TNF-α, TNF-α/IL-10,NF-κB and caspase. It showed the potent inhibition of CYP3A4, with IC50 values of 6.20 μM (CYP3A4/testosterone) and 19.10 μM (CYP3A4/midazolam).
    Targets: HIV | P450 (e.g. CYP17) | TLR | TNF-α | NF-κB
    In vitro:
    J Nat Sci Biol Med. 2013 Jan;4(1):126-33.
    Influence of limonin on Wnt signalling molecule in HepG2 cell lines.[Pubmed: 23633848]
    The role of limonin as potent anti carcinogenic, apoptosis and chemotherapeutic agents has been supported by limited studies.
    METHODS AND RESULTS:
    In this study, limonin is identified as a potent anti proliferative agent against human hepatoma HepG2 cells based on the cell viability study, LDH leakage assay. Induction of apoptosis in HepG2 cells by limonin was evidenced by western blot analysis of Bax, Cyclin D1, Caspase 3 and Caspase9. Since Wnt signalling is involved in the initiation and sustaining of hepatocellular carcinoma we studied differential expression of LRP5, LRP6 and DKK wnt players.
    CONCLUSIONS:
    Limonin found to down regulate these players which forms a rationale for further investigation on effect on limonin in cancer therapy.
    Planta Med. 2003 Oct;69(10):910-3.
    Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells.[Pubmed: 14648393]
    In the last years several plant-derived natural compounds have been screened for their anti-HIV activity in order to find lead compounds with novel structures or mechanisms of action. Among these, several triterpenoids have been found to exhibit an antiretroviral activity with different mechanisms of action.
    METHODS AND RESULTS:
    In this study the effect of two limonoids, limonin and nomilin, on the growth of human immunodeficiency virus-1 (HIV-1) in culture of human peripheral blood mononuclear cells (PBMC) and on monocytes/macrophages (M/M) is described. Limonin and nomilin were found to inhibit the HIV-1 replication in all cellular systems used. A dose-dependent inhibition of viral replication was observed in PBMC isolated from healthy donors and infected with HIV-1 strain after incubation with limonin and nomilin (EC (50) values: 60.0 microM and 52.2 microM, respectively). The two terpenoids inhibited at all concentrations studied the production of HIV-p24 antigen even when the PBMC employed were chronically infected (EC (50) values of 61.0 microM for limonin and 76.2 microM for nomilin). Moreover, these compounds inhibited the HIV-1 replication even in infected M/M. In this cellular system the inhibitory effect was significant at the concentrations of 20 microM, 40 microM and 80 microM starting from day 14 and reached the maximum effect after 18 days of incubation. As regards the mechanism of action, limonin and nomilin inhibit in vitro HIV-1 protease activity.
    CONCLUSIONS:
    In general, the results obtained point out a similar anti-HIV activity of limonin and nomilin indicating that this activity is not drastically influenced by the structural difference between the two compounds.
    In vivo:
    Eur J Pharmacol. 2014 Oct 5;740:676-82.
    Limonin attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway.[Pubmed: 24967531]
    Limonin has been shown to exhibit anti-inflammatory and antioxidant properties in the settings of chemically induced hepatic injury.
    METHODS AND RESULTS:
    The current study aimed to investigate the protective effects of limonin on experimentally-induced hepatic ischemia reperfusion (I/R) injury in rats. Rats were injected IP with either DMSO or limonin (100 mg/kg BW), 30 min before submission to 45 min of ischemia, followed by 1 h of reperfusion. Limonin ameliorated the deleterious effects of I/R as indicated by improvement in liver function tests, reduction of lactate dehydrogenase, reduction of oxidative stress, decrease in hepatocyte degeneration, and pyknosis. Furthermore, pretreatment of I/R rats with limonin, induced a significant down regulation in the various elements of the toll like receptor (TLR)pathway including TLR-2 and TLR-4, myeloid differentiation factor 88 (MYD88) and toll/IR-1(TIR)-domain-containing adaptor protein inducing interferon-beta (TRIF) and the downstream effectors TNF-α, TNF-α/IL-10 ratio and nuclear factor-κB (NF-κB). It also increased the anti-inflammatory cytokine IL-10 and decreased the activity of the apoptotic marker, caspase-3.
    CONCLUSIONS:
    These data indicate that limonin exerts antioxidant and anti-inflammatory effects in ischemic liver, thus, protecting hepatocytes against I/R injury in rats. The mechanism of these hepatoprotective effects appears to be related to the antioxidant and anti-inflammatory potential of limonin mediated by the down regulation of TLR- signaling pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1254 mL 10.627 mL 21.254 mL 42.508 mL 53.135 mL
    5 mM 0.4251 mL 2.1254 mL 4.2508 mL 8.5016 mL 10.627 mL
    10 mM 0.2125 mL 1.0627 mL 2.1254 mL 4.2508 mL 5.3135 mL
    50 mM 0.0425 mL 0.2125 mL 0.4251 mL 0.8502 mL 1.0627 mL
    100 mM 0.0213 mL 0.1063 mL 0.2125 mL 0.4251 mL 0.5313 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柠檬酸; Limonexic acid CFN97565 99026-99-0 C26H30O10 = 502.5 5mg QQ客服:3257982914
    Isolimonexic acid; Isolimonexic acid CFN96839 73904-93-5 C26H30O10 = 502.51 5mg QQ客服:3257982914
    Limonol; Limonol CFN97564 989-61-7 C26H32O8 = 472.5 5mg QQ客服:2056216494
    柠檬苦素; Limonin CFN99280 1180-71-8 C26H30O8 = 470.5 20mg QQ客服:1413575084
    海罂粟碱B; Glaucin B CFN99256 115458-73-6 C28H32O10 = 528.6 5mg QQ客服:2159513211
    吴茱萸苦素; Rutaevin CFN96685 33237-37-5 C26H30O9 = 486.51 20mg QQ客服:1457312923
    吴茱萸苦素 7-乙酯; Rutaevin 7-acetate CFN91983 62306-81-4 C28H32O10 = 528.55 5mg QQ客服:2159513211
    吴茱萸醇; Evodol CFN98214 22318-10-1 C26H28O9 = 484.5 5mg QQ客服:1413575084
    12alpha-羟基吴茱萸醇; 12alpha-Hydroxyevodol CFN99328 120722-04-5 C26H28O10 = 500.5 5mg QQ客服:2159513211

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