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  • Isolimonexic acid

    Isolimonexic acid

    Isolimonexic acid
    产品编号 CFN96839
    CAS编号 73904-93-5
    分子式 = 分子量 C26H30O10 = 502.51
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruits and leaves of Euodia daniellii.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Isolimonexic acid CFN96839 73904-93-5 1mg QQ客服:1457312923
    Isolimonexic acid CFN96839 73904-93-5 5mg QQ客服:1457312923
    Isolimonexic acid CFN96839 73904-93-5 10mg QQ客服:1457312923
    Isolimonexic acid CFN96839 73904-93-5 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Brasilia (Brazil)
  • National Cancer Center Research Institute (Japan)
  • University of Medicine and Pharmacy (Romania)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Max-Planck-Insitut (Germany)
  • Universitas Airlangga (Indonesia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Melbourne University (Australia)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Complutense University of Madrid (Spain)
  • University of Indonesia (Indonesia)
  • Osmania University (India)
  • University of Mysore (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • iScience.2023, 26(9):107602.
  • Front Microbiol.2019, 10:2806
  • J. of Med. Plant Research.2013, 90-151
  • Oxid Med Cell Longev2020, 12
  • Biomolecules.2020, 10(2):E184
  • Molecules.2021, 26(12):3652.
  • Journal of Food Quality2022, P:13, 6256310.
  • J Appl Biol Chem2022, 65:343−348.
  • Bioorg Med Chem.2020, 28(12):115553.
  • Pak J Pharm Sci.2018, 31:311-315
  • US20170000760 A12016, 42740
  • Microchemical Journal2024: 196:109676.
  • Food Funct.2022, doi: 10.1039
  • Int J Mol Sci.2022, 23(20):12516.
  • Natural Product Communications2020, doi: 10.1177.
  • Microchemical Journal2018, 137:168-173
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • Plant Physiol Biochem.2019, 144:355-364
  • J of l. Chroma.&Related Tech2020, 43(11-12):414-423.
  • Nutrients.2018, 10(12):E1998
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • Molecules.2019, 24(17):E3127
  • Toxins (Basel).2021, 13(12):898.
  • ...
  • 生物活性
    Description: Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
    Targets: Estrogen receptor | Bcl-2/Bax | Caspase | p53 | COX | Progestogen receptor
    In vitro:
    Food Funct. 2013 Feb;4(2):258-65.
    Limonoids and their anti-proliferative and anti-aromatase properties in human breast cancer cells.[Pubmed: 23117440 ]

    METHODS AND RESULTS:
    The compounds were identified by TLC, HPLC, and LC-MS techniques. A panel of 9 purified limonoids, including limonin, nomilin, obacunone, limonexic acid (LNA), Isolimonexic acid (ILNA), nomilinic acid glucoside (NAG), deacetyl nomilinic acid glucoside (DNAG), limonin glucoside (LG) and obacunone glucoside (OG) as well as 4 modified compounds such as limonin methoxime (LM), limonin oxime (LO), defuran limonin (DL), and defuran nomilin (DN), were screened for their cytotoxicity on estrogen receptor (ER)-positive (MCF-7) or ER-negative (MDA-MB-231) human breast cancer cells. We further tested the mechanism of the anti-proliferative activity of limonoids using an in vitro aromatase enzyme assay and western blot with anti-caspase-7. Among the tested limonoids, 11 limonoids exhibited cytotoxicity on MCF-7 whereas 8 limonoids showed cytotoxicity against the MDA-MB-231 cell lines. Although most of the limonoids showed anti-aromatase activity, the inhibition of proliferation was not related to the anti-aromatase activity. On the other hand, the anti-proliferative activity was significantly correlated with caspase-7 activation by limonoids.
    CONCLUSIONS:
    Our findings indicated that the citrus limonoids may have potential for the prevention of estrogen-responsive breast cancer (MCF-7) via caspase-7 dependent pathways.
    J Agric Food Chem. 2009 Nov 25;57(22):10933-42.
    Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells.[Pubmed: 19919125]
    Lime (Citrus aurantifolia Swingle) is one of the major citrus fruits and widely consumed, but there is limited evidence about its health-promoting properties.
    METHODS AND RESULTS:
    Hence, an investigation was conducted to understand the chemopreventive effects of lime juice on pancreatic cancer cells and the possible mechanism for induction of apoptosis using Panc-28 cells. Freeze-dried lime juice was extracted with different solvents, such as chloroform, acetone, MeOH, and MeOH/water (8:2). The chloroform extract showed the highest (85.4 and 90%) radical-scavenging activity by 1,1-diphenyl-2-picryl hydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) methods at 624 microg/mL, whereas the MeOH/water extract showed the lowest (<20%) activity. The active components were identified by high-performance liquid chromatography (HPLC) using a C-18 column as rutin, neohesperidin, hesperidin, and hesperitin. Furthermore, the limonoids identified are limonexic acid, Isolimonexic acid, and limonin. All of the extracts of lime juice inhibited Panc-28 cancer cell growth. The MeOH extract exhibited the maximum activity, with an IC50 value of 81.20 microg/mL after 72 h. The inhibition of Panc-28 cells was in the range of 73-89%, at 100 microg/mL at 96 h. The involvement of apoptosis in induction of cytotoxicity was confirmed by expression of Bax, Bcl-2, casapase-3, and p53.
    CONCLUSIONS:
    The results of the present study clearly indicate that antioxidant activity is proportionate to the content of flavonoids and proliferation inhibition ability is proportionate to the content of both flavonoids and limonoids.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.99 mL 9.9501 mL 19.9001 mL 39.8002 mL 49.7503 mL
    5 mM 0.398 mL 1.99 mL 3.98 mL 7.96 mL 9.9501 mL
    10 mM 0.199 mL 0.995 mL 1.99 mL 3.98 mL 4.975 mL
    50 mM 0.0398 mL 0.199 mL 0.398 mL 0.796 mL 0.995 mL
    100 mM 0.0199 mL 0.0995 mL 0.199 mL 0.398 mL 0.4975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柠檬酸; Limonexic acid CFN97565 99026-99-0 C26H30O10 = 502.5 5mg QQ客服:1413575084
    Isolimonexic acid; Isolimonexic acid CFN96839 73904-93-5 C26H30O10 = 502.51 5mg QQ客服:1413575084
    Limonol; Limonol CFN97564 989-61-7 C26H32O8 = 472.5 5mg QQ客服:2056216494
    柠檬苦素; Limonin CFN99280 1180-71-8 C26H30O8 = 470.5 20mg QQ客服:3257982914
    海罂粟碱B; Glaucin B CFN99256 115458-73-6 C28H32O10 = 528.6 5mg QQ客服:3257982914
    吴茱萸苦素; Rutaevin CFN96685 33237-37-5 C26H30O9 = 486.51 20mg QQ客服:3257982914
    吴茱萸苦素 7-乙酯; Rutaevin 7-acetate CFN91983 62306-81-4 C28H32O10 = 528.55 5mg QQ客服:3257982914
    吴茱萸醇; Evodol CFN98214 22318-10-1 C26H28O9 = 484.5 5mg QQ客服:2159513211
    12alpha-羟基吴茱萸醇; 12alpha-Hydroxyevodol CFN99328 120722-04-5 C26H28O10 = 500.5 5mg QQ客服:2056216494

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