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  • 4'-羟基汉黄芩素

    4'-Hydroxywogonin

    4'-羟基汉黄芩素
    产品编号 CFN98960
    CAS编号 57096-02-3
    分子式 = 分子量 C16H12O6 = 300.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria baicalensis Georgi
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4'-羟基汉黄芩素 CFN98960 57096-02-3 1mg QQ客服:2159513211
    4'-羟基汉黄芩素 CFN98960 57096-02-3 5mg QQ客服:2159513211
    4'-羟基汉黄芩素 CFN98960 57096-02-3 10mg QQ客服:2159513211
    4'-羟基汉黄芩素 CFN98960 57096-02-3 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medical University of South Carolina (USA)
  • National Chung Hsing University (Taiwan)
  • Chulalongkorn University (Thailand)
  • Regional Crop Research Institute (Korea)
  • Macau University of Science and Technology (China)
  • Universidade do Porto (Portugal)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Colorado State University (USA)
  • Hamdard University (India)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Universit?t Basel (Switzerland)
  • Tohoku University (Japan)
  • Univerzita Karlova v Praze (Czech Republic)
  • The Ohio State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • FEBS Lett.2015, 589(1):182-7
  • J Pharm Biomed Anal2016, 118:183-194
  • Am J Chin Med.2016, 44(6):1255-1271
  • Am J Chin Med.2016, 44(8):1719-1735
  • Research on Crops.2017, 18(2)
  • Phytomedicine.2017, 24:77-86
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • Oncotarget.2017, 9(3):4161-4172
  • Front Aging Neurosci.2018, 10:269
  • European Journal of Integrative Medicine2018, 20:165-172
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • World J Mens Health.2019, 10.5534
  • Food Res Int.2019, 123:125-134
  • Chinese Medicine2019, 14(1)
  • BMC Complement Altern Med.2019, 19(1):339
  • J Ethnopharmacol.2019, 236:31-41
  • Molecules.2019, 24(9):E1719
  • The Malaysian journal of pathology2019, 41(3):243-251
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Planta Med.2019, 85(3):217-224
  • Nutrients2020, 12(2):488
  • Molecules.2020, 25(3):734
  • ...
  • 生物活性
    Description: 4'-Hydroxywogonin has positive effect on inhabiting those human tumor lines in vitro, with IC50 value is 8.3-38.4ug/mL .
    Targets: NO
    In vitro:
    Planta Med. 2011 Mar;77(4):388-93.
    Chromatographic fingerprint and quantitative analysis of seven bioactive compounds of Scutellaria barbata.[Pubmed: 20862635]
    Scutellaria barbata D. Don is widely used as a folk antitumor and anti-inflammatory agent in Asia. However, a simple and global quality control method for S. barbata was lacking. In this study, six phenolic compounds, including P-coumaric acid, scutellarin, apigenin 5-O-β-glucopyranoside, luteolin, apigenin and 4'-hydroxywogonin were obtained from S. barbata by phytochemical investigations.
    METHODS AND RESULTS:
    The six compounds plus baicalein show cytotoxcities to the nine human cancer cells, K562, MGC-803, HL60, SH-SY5Y, SW1116, SMMC-7221, SW480, HepG2 and KB. Subsequently, a high-performance liquid chromatography with photodiode array detector (HPLC-DAD) was developed for both fingerprint analysis of S. barbata and quantitative determination of the seven anticancer active compounds in S. barbata. The chromatographic separation was accomplished on an Ultimate™ XB-C18 column (4.6 x 250 mm, 5 µm) in 65 min. For fingerprinting, 26 common peaks were found and selected as characteristic peaks to assess the consistency of S. barbata samples. For quantitative analysis, the seven bioactive compounds showed good regression relationship ( R² > 0.999) within test ranges and the recovery of the method was in the range of 90-105 %.
    CONCLUSIONS:
    In brief, the present study provides the fingerprint analysis and quantitative methods for global and systematical quality control of S. barbata for its anticancer usage.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    三裂鼠尾草素; Salvigenin CFN99883 19103-54-9 C18H16O6 = 328.3 10mg QQ客服:1413575084
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:2932563308
    4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin CFN93255 6601-66-7 C19H18O6 = 342.4 5mg QQ客服:1413575084
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:2932563308
    栀子黄素B; Gardenin B CFN93144 2798-20-1 C19H18O7 = 358.4 10mg QQ客服:3257982914
    桔皮素; Tangeretin CFN90240 481-53-8 C20H20O7 = 372.37 20mg QQ客服:1148253675
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 5mg QQ客服:215959384
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:215959384
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:2159513211
    黄花夹竹桃黄酮; Thevetiaflavone CFN96124 29376-68-9 C16H12O5 = 284.3 5mg QQ客服:215959384

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