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  • Vitexolide D

    Vitexolide D

    Vitexolide D
    产品编号 CFN96446
    CAS编号 1788090-69-6
    分子式 = 分子量 C20H30O3 = 318.45
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Vitex vestita
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Vitexolide D CFN96446 1788090-69-6 1mg QQ客服:3257982914
    Vitexolide D CFN96446 1788090-69-6 5mg QQ客服:3257982914
    Vitexolide D CFN96446 1788090-69-6 10mg QQ客服:3257982914
    Vitexolide D CFN96446 1788090-69-6 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • MTT Agrifood Research Finland (Finland)
  • Wroclaw Medical University (Poland)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Max-Planck-Insitut (Germany)
  • Julius Kühn-Institut (Germany)
  • Heidelberg University (Germany)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Illinois at Chicago (USA)
  • University of Hawaii Cancer Center (USA)
  • Charles University in Prague (Czech Republic)
  • Kyushu University (Japan)
  • Shanghai University of TCM (China)
  • Universit?t Basel (Switzerland)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chem Biol Interact.2018, 283:59-74
  • Molecules.2018, 23(10):E2638
  • Food Engineering Progress2019, 23(3)209-216
  • Front Microbiol.2020, 11:583594.
  • J Food Biochem.2020, 44(6):e13198.
  • Chem Biol Interact.2019, 298:1-7
  • J Sep Sci.2022, 45(18):3556-3566.
  • 2023, 24(6):5769.Int J Mol Sci.
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Front Pharmacol.2016, 7:460
  • Food Analytical Methods2017, 10:3225-3234
  • Natural Product Communications2020, doi: 10.1177.
  • Toxicol Res.2019, 35(4):371-387
  • Planta Medica International2022, 9(01):e108-e115.
  • Natural Product Communications2020, doi: 10.1177.
  • J Agric Food Chem.2016, 64(35):6783-90
  • J Ginseng Res.2020, 44(4):611-618.
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • Pharmaceuticals.2022, 15(4), 402.
  • Front Immunol. 2020, 11:62.
  • Int J Biol Macromol.2018, 112:1093-1103
  • Nutr Res Pract.2020, 14(3):203-217.
  • ...
  • 生物活性
    Description: Vitexolide D shows moderate antibacterial activity against a panel of 46 Gram-positive strains. It also shows cytotoxic activities against the HCT-116 cancer cell line and human fetal lung fibroblast MRC5 cell line (1 < IC50s < 10 uM).
    Targets: Antifection
    In vitro:
    J Nat Prod. 2015 Jun 26;78(6):1348-56.
    Antibacterial Labdane Diterpenoids from Vitex vestita.[Pubmed: 26034885 ]

    METHODS AND RESULTS:
    Bioassay-guided purification of the dichloromethane extract of the leaves of the Malaysian species Vitex vestita, led to the isolation of six new labdane-type diterpenoids, namely, 12-epivitexolide A (2), vitexolides B and C (3 and 4), vitexolide E (8), and vitexolins A and B (5 and 6), along with six known compounds, vitexolide A (1) and Vitexolide D (7), acuminolide (9), 3β-hydroxyanticopalic acid (10), 8α-hydroxyanticopalic acid (11), and 6α-hydroxyanticopalic acid (12). Their structures were elucidated on the basis of 1D and 2D NMR analyses and HRMS experiments. Both variable-temperature NMR spectroscopic studies and chemical modifications were performed to investigate the dynamic epimerization of the γ-hydroxybutenolide moiety of compounds 1-4. Compounds were assayed against a panel of 46 Gram-positive strains.
    CONCLUSIONS:
    Vitexolide A (1) exhibited the most potent antibacterial activity with minimal inhibitory concentration values ranging from 6 to 96 μM, whereas compounds 2 and 6-9 showed moderate antibacterial activity. The presence of a β-hydroxyalkyl-γ-hydroxybutenolide subunit contributed significantly to antibacterial activity. Compounds 1-4 and 6-9 showed cytotoxic activities against the HCT-116 cancer cell line (1 < IC50s < 10 μM) and human fetal lung fibroblast MRC5 cell line (1 < IC50s < 10 μM for compounds 1, 2, 7, 8, and 9).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1402 mL 15.7011 mL 31.4021 mL 62.8042 mL 78.5053 mL
    5 mM 0.628 mL 3.1402 mL 6.2804 mL 12.5608 mL 15.7011 mL
    10 mM 0.314 mL 1.5701 mL 3.1402 mL 6.2804 mL 7.8505 mL
    50 mM 0.0628 mL 0.314 mL 0.628 mL 1.2561 mL 1.5701 mL
    100 mM 0.0314 mL 0.157 mL 0.314 mL 0.628 mL 0.7851 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Andropanolide; Andropanolide CFN97600 869807-57-8 C20H30O5 = 350.45 5mg QQ客服:3257982914
    穿心莲内酯; Andrographolide CFN98923 5508-58-7 C20H30O5 = 350.5 20mg QQ客服:2056216494
    14-去氧-11,12-二去氢穿心莲内酯; 14-Deoxy-11,12-didehydroandrographolide CFN98666 42895-58-9 C20H28O4 = 332.4 20mg QQ客服:3257982914
    脱水穿心莲内酯; Dehydroandrographolide CFN99770 134418-28-3 C20H28O4 = 332.43 20mg QQ客服:2159513211
    14-去氧穿心莲内酯; 14-Deoxyandrographolide CFN92802 4176-97-0 C20H30O4 = 334.45 10mg QQ客服:3257982914
    去氧穿心莲内酯; Deoxyandrographolide CFN90518 79233-15-1 C20H30O4 = 334.45 20mg QQ客服:3257982914
    14-去氧基-17-羟基穿心莲内酯; 14-Deoxy-17-hydroxyandrographolide CFN97601 869384-82-7 C20H32O5 = 352.47 5mg QQ客服:2056216494
    14-去氧基-11-羟基穿心莲内酯; 14-Deoxy-11-hydroxyandrographolide CFN97815 160242-09-1 C20H30O5 = 350.45 5mg QQ客服:2056216494
    14-去氧-12-羟基穿心莲内酯; 14-Deoxy-12-hydroxyandrographolide CFN97785 219721-33-2 C20H30O5 = 350.45 5mg QQ客服:2056216494
    Vitexolide D; Vitexolide D CFN96446 1788090-69-6 C20H30O3 = 318.45 5mg QQ客服:1413575084

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