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  • 14-去氧穿心莲内酯

    14-Deoxyandrographolide

    14-去氧穿心莲内酯
    产品编号 CFN92802
    CAS编号 4176-97-0
    分子式 = 分子量 C20H30O4 = 334.45
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Andrographis paniculata (Burm. f.) Nees
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    14-去氧穿心莲内酯 CFN92802 4176-97-0 1mg QQ客服:2159513211
    14-去氧穿心莲内酯 CFN92802 4176-97-0 5mg QQ客服:2159513211
    14-去氧穿心莲内酯 CFN92802 4176-97-0 10mg QQ客服:2159513211
    14-去氧穿心莲内酯 CFN92802 4176-97-0 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Cornell University (USA)
  • University of Ioannina (Greece)
  • Colorado State University (USA)
  • Universidad Veracuzana (Mexico)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Universidade da Beira Interior (Germany)
  • University of Wollongong (Australia)
  • University of Liège (Belgium)
  • University of Vigo (Spain)
  • Charles Sturt University (Denmark)
  • Indian Institute of Science (India)
  • University of Virginia (USA)
  • Aarhus University (Denmark)
  • Universita' Degli Studi Di Cagliari (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • FEBS J.2022, 10.1111:febs.16676.
  • Research Square2020, doi: 10.21203.
  • Wageningen University & Research2018, January 2018
  • J Ethnopharmacol.2018, 210:88-94
  • Cell.2022, 185(23):4298-4316.e21.
  • JMSACL2023, 09.002
  • Drug Invention Today2019, 12(6):1303-1306
  • Journal of Apicultural Research2021, 60(1)
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Molecules.2021, 26(9):2526.
  • J.Food Processing & Preservation2022, jfpp.16666
  • J Mater Chem B.2019, 7(39):5896-5919
  • Food Chem.2019, 279:80-87
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Phytomedicine.2015, 22(14):1262-8
  • Molecules.2022, 27(7):2360.
  • Plants (Basel).2022, 11(16):2126.
  • J Food Biochem.2021, 45(7):e13774.
  • Front Cell Dev Biol.2020, 8:32.
  • Food Chemistry: X2023, 101032.
  • Chinese Medicine2019, 14(1)
  • Food Funct.2021, 12(13):5892-5902.
  • BMC Plant Biol.2020, 20(1):214.
  • ...
  • 生物活性
    Description: 14-Deoxyandrographolide has hepatoprotective activity, mediates activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS, may provide a promising approach in the prevention of liver diseases during chronic alcoholism. It desensitizes hepatocytes to TNF-alpha-mediated apoptosis through the release of TNFRSF1A.
    Targets: AMPK | NOS | cAMP | TNF-α | ATPase | Calcium Channel
    In vitro:
    Br J Pharmacol. 2010 Aug;160(7):1823-43.
    14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway.[Pubmed: 20649583]
    Andrographis paniculata (AP) has been found to display hepatoprotective effect, although the mechanism of action of the active compounds of AP in this context still remains unclear. Here, we evaluated the hepatoprotective efficacy of 14-deoxyandrographolide (14-DAG), a bioactive compound of AP, particularly its role in desensitization of hepatocytes to tumour necrosis factor-alpha (TNF-alpha)-induced signalling of apoptosis.
    METHODS AND RESULTS:
    TNF-alpha-mediated ligand receptor interaction in hepatocytes in the presence of 14-DAG was studied in vitro in primary hepatocyte cultures, with the help of co-immunoprecipitation, confocal microscopy and FACS analysis. Events associated with 14-DAG-induced TNFRSF1A release from hepatocytes were determined using immunoblotting, biochemical assay and fluorimetric studies. Pulse-chase experiments with radiolabelled TNF-alpha and detection of apoptotic nuclei by terminal transferase-mediated dUTP nick-end labelling were performed under in vivo conditions. 14-DAG down-regulated the formation of death-inducing signalling complex, resulting in desensitization of hepatocytes to TNF-alpha-induced apoptosis. Pretreatment of hepatocytes with 14-DAG accentuated microsomal Ca-ATPase activity through induction of NO/cGMP pathway. This resulted in enhanced calcium influx into microsomal lumen with the formation of TNFRSF1A-ARTS-1-NUCB2 complex in cellular vesicles. It was followed by the release of full-length 55 kDa TNFRSF1A and a reduction in the number of cell surface TNFRSF1A, which eventually caused diminution of TNF-alpha signal in hepatocytes.
    CONCLUSIONS:
    Taken together, the results demonstrate for the first time that 14-DAG desensitizes hepatocytes to TNF-alpha-mediated apoptosis through the release of TNFRSF1A. This can be used as a strategy against cytokine-mediated hepatocyte apoptosis in liver dysfunctions.
    In vivo:
    Food Chem Toxicol. 2013 Sep;59:236-48.
    14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats.[Pubmed: 23764359]
    Chronic alcoholism is one of the most common causes of liver diseases worldwide. Nitric oxide (NO) has been proposed to have potential for clinical application against chronic hepatocellular injuries. However, mechanisms underlying hepatoprotective functions of NO in ethanol-induced apoptosis are largely unknown.
    METHODS AND RESULTS:
    Sprauge-Dawley rats were exposed to ethanol for 8 weeks. Half of the ethanol-fed animals received 14-Deoxyandrographolide (14-DAG) treatment for the last 4 weeks of study. Preventive effect of 14-Deoxyandrographolide against ethanol-induced hepatotoxicity involved constitutive nitric oxide synthase (cNOS) activation followed by up-regulation of γ-glutamylcysteine synthetase activity and reduced oxidative stress. 14-Deoxyandrographolide acted as activator of adenylate cyclase and modulated cyclic AMP (cAMP) mediated expression of caveolin-1 and calmodulin.
    CONCLUSIONS:
    Our results suggest that, protective effect of 14-Deoxyandrographolide against ethanol-induced hepatic injury is based on its ability to reduce oxidative stress through cNOS dependent improvement of redox status. 14-Deoxyandrographolide mediated activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.99 mL 14.9499 mL 29.8998 mL 59.7997 mL 74.7496 mL
    5 mM 0.598 mL 2.99 mL 5.98 mL 11.9599 mL 14.9499 mL
    10 mM 0.299 mL 1.495 mL 2.99 mL 5.98 mL 7.475 mL
    50 mM 0.0598 mL 0.299 mL 0.598 mL 1.196 mL 1.495 mL
    100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.598 mL 0.7475 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Andropanolide; Andropanolide CFN97600 869807-57-8 C20H30O5 = 350.45 5mg QQ客服:1413575084
    穿心莲内酯; Andrographolide CFN98923 5508-58-7 C20H30O5 = 350.5 20mg QQ客服:1457312923
    14-去氧-11,12-二去氢穿心莲内酯; 14-Deoxy-11,12-didehydroandrographolide CFN98666 42895-58-9 C20H28O4 = 332.4 20mg QQ客服:3257982914
    脱水穿心莲内酯; Dehydroandrographolide CFN99770 134418-28-3 C20H28O4 = 332.43 20mg QQ客服:215959384
    14-去氧穿心莲内酯; 14-Deoxyandrographolide CFN92802 4176-97-0 C20H30O4 = 334.45 10mg QQ客服:3257982914
    去氧穿心莲内酯; Deoxyandrographolide CFN90518 79233-15-1 C20H30O4 = 334.45 20mg QQ客服:215959384
    14-去氧基-17-羟基穿心莲内酯; 14-Deoxy-17-hydroxyandrographolide CFN97601 869384-82-7 C20H32O5 = 352.47 5mg QQ客服:3257982914
    14-去氧基-11-羟基穿心莲内酯; 14-Deoxy-11-hydroxyandrographolide CFN97815 160242-09-1 C20H30O5 = 350.45 5mg QQ客服:1413575084
    14-去氧-12-羟基穿心莲内酯; 14-Deoxy-12-hydroxyandrographolide CFN97785 219721-33-2 C20H30O5 = 350.45 5mg QQ客服:1413575084
    Vitexolide D; Vitexolide D CFN96446 1788090-69-6 C20H30O3 = 318.45 5mg QQ客服:2159513211

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