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  • 去氧穿心莲内酯

    Deoxyandrographolide

    去氧穿心莲内酯
    产品编号 CFN90518
    CAS编号 79233-15-1
    分子式 = 分子量 C20H30O4 = 334.45
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Andrographis paniculata (Burm. f.) Nees
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去氧穿心莲内酯 CFN90518 79233-15-1 10mg QQ客服:2056216494
    去氧穿心莲内酯 CFN90518 79233-15-1 20mg QQ客服:2056216494
    去氧穿心莲内酯 CFN90518 79233-15-1 50mg QQ客服:2056216494
    去氧穿心莲内酯 CFN90518 79233-15-1 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of East Anglia (United Kingdom)
  • Monash University Sunway Campus (Malaysia)
  • National Chung Hsing University (Taiwan)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Julius Kühn-Institut (Germany)
  • University of Toronto (Canada)
  • Mahatma Gandhi University (India)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • St. Jude Children Research Hospital (USA)
  • Griffith University (Australia)
  • Pennsylvania State University (USA)
  • University of Brasilia (Brazil)
  • University of Parma (Italy)
  • Istanbul University (Turkey)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutrients.2019, 11(4):E936
  • Preprints2022, 202211.0388.v1.
  • Pharmacol Rep.2017, 69(6):1224-1231
  • FEBS Lett.2015, 589(1):182-7
  • J Nat Prod.2019, 82(4):1002-1008
  • Biol Pharm Bull.2020, 43(10):1534-1541.
  • Biochem Pharmacol.2017, 130:10-20
  • J Am Soc Mass Spectrom.2021, 32(5):1205-1214.
  • Molecules.2020, 25(18),4089.
  • J Med Food.2021, 24(3):209-217.
  • Front Immunol.2018, 9:2655
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Nutr Res Pract.2020, 14(5):478-489.
  • J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
  • Molecules2020, 25(4):892
  • Int. J of Herbal Med.2023, 11(1): 06-14
  • Food Chem.2020, 327:126992.
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • Antioxidants.2022, 11(3):592.
  • National University of Pharmacy2022, 1:73-76
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • ...
  • 生物活性
    Description: Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo.
    Targets: PI3K | Akt | AMPK | GLUT | LDL
    In vivo:
    Eur J Pharmacol. 2015 Dec 5;768:207-16.
    Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo.[Pubmed: 26528798 ]
    Skeletal muscle is the principal site for postprandial glucose utilization and augmenting the rate of glucose utilization in this tissue may help to control hyperglycemia associated with diabetes mellitus.
    METHODS AND RESULTS:
    Here, we explored the effect of Deoxyandrographolide (DeoAn) isolated from the Andrographis paniculata Nees on glucose utilization in skeletal muscle and investigated its antihyperglycemic effect in vivo in streptozotocin-induced diabetic rats and genetically diabetic db/db mice. In L6 myotubes, DeoAn dose-dependently stimulated glucose uptake by enhancing the translocation of glucose transporter 4 (GLUT4) to cell surface, without affecting the total cellular GLUT4 and GLUT1 content. These effects of DeoAn were additive to insulin. Further analysis revealed that DeoAn activated PI-3-K- and AMPK-dependent signaling pathways, account for the augmented glucose transport in L6 myotubes. Furthermore, DeoAn lowered postprandial blood glucose levels in streptozotocin-induced diabetic rats and also suppressed the rises in the fasting blood glucose, serum insulin, triglycerides and LDL-Cholesterol levels of db/db mice.
    CONCLUSIONS:
    These findings suggest the therapeutic efficacy of the DeoAn for type 2 diabetes mellitus and can be potential phytochemical for its management.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.99 mL 14.9499 mL 29.8998 mL 59.7997 mL 74.7496 mL
    5 mM 0.598 mL 2.99 mL 5.98 mL 11.9599 mL 14.9499 mL
    10 mM 0.299 mL 1.495 mL 2.99 mL 5.98 mL 7.475 mL
    50 mM 0.0598 mL 0.299 mL 0.598 mL 1.196 mL 1.495 mL
    100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.598 mL 0.7475 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Andropanolide; Andropanolide CFN97600 869807-57-8 C20H30O5 = 350.45 5mg QQ客服:215959384
    穿心莲内酯; Andrographolide CFN98923 5508-58-7 C20H30O5 = 350.5 20mg QQ客服:215959384
    14-去氧-11,12-二去氢穿心莲内酯; 14-Deoxy-11,12-didehydroandrographolide CFN98666 42895-58-9 C20H28O4 = 332.4 20mg QQ客服:1457312923
    脱水穿心莲内酯; Dehydroandrographolide CFN99770 134418-28-3 C20H28O4 = 332.43 20mg QQ客服:2159513211
    14-去氧穿心莲内酯; 14-Deoxyandrographolide CFN92802 4176-97-0 C20H30O4 = 334.45 10mg QQ客服:2056216494
    去氧穿心莲内酯; Deoxyandrographolide CFN90518 79233-15-1 C20H30O4 = 334.45 20mg QQ客服:2056216494
    14-去氧基-17-羟基穿心莲内酯; 14-Deoxy-17-hydroxyandrographolide CFN97601 869384-82-7 C20H32O5 = 352.47 5mg QQ客服:215959384
    14-去氧基-11-羟基穿心莲内酯; 14-Deoxy-11-hydroxyandrographolide CFN97815 160242-09-1 C20H30O5 = 350.45 5mg QQ客服:215959384
    14-去氧-12-羟基穿心莲内酯; 14-Deoxy-12-hydroxyandrographolide CFN97785 219721-33-2 C20H30O5 = 350.45 5mg QQ客服:2056216494
    Vitexolide D; Vitexolide D CFN96446 1788090-69-6 C20H30O3 = 318.45 5mg QQ客服:1413575084

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