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  • 14-去氧-12-羟基穿心莲内酯

    14-Deoxy-12-hydroxyandrographolide

    14-去氧-12-羟基穿心莲内酯
    产品编号 CFN97785
    CAS编号 219721-33-2
    分子式 = 分子量 C20H30O5 = 350.45
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Andrographis paniculata (Burm. f.) Nees
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    14-去氧-12-羟基穿心莲内酯 CFN97785 219721-33-2 1mg QQ客服:2056216494
    14-去氧-12-羟基穿心莲内酯 CFN97785 219721-33-2 5mg QQ客服:2056216494
    14-去氧-12-羟基穿心莲内酯 CFN97785 219721-33-2 10mg QQ客服:2056216494
    14-去氧-12-羟基穿心莲内酯 CFN97785 219721-33-2 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Malaya (Malaysia)
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  • Anna University (India)
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  • Instituto Politécnico de Bragan?a (Portugal)
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  • National Cancer Center Research Institute (Japan)
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  • Macau University of Science and Technology (China)
  • Aveiro University (Portugal)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2021, 26(8):2161.
  • J Biochem Mol Toxicol.2017, 31(9)
  • Invest New Drugs.2017, 35(2):166-179
  • Anal Chim Acta.2021, 1180:338874.
  • Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
  • Natural Product Communications2020, doi: 10.1177.
  • Korean J Pain.2021, 34(4):405-416.
  • J Chromatogr A.2017, 1518:46-58
  • J Appl Biol Chem2021, 64(3):245-251.
  • J Biomol Struct Dyn.2022, 5;1-17.
  • Biol Pharm Bull.2020, 43(10):1534-1541.
  • Molecules2022, 27(9):2827.
  • J Biomol Struct Dyn.2022, 1-21.
  • Int J Mol Sci.2022, 23(24):16000.
  • J Nat Prod.2019, 82(4):1002-1008
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Int. J. of Food Properties2017, S108-S118
  • Mediators Inflamm. 2016, 2016:6189590
  • Universidade Estadual Paulista2017, 42785
  • Toxicol In Vitro.2022, 81:105346.
  • Int J Mol Sci.2022, 23(11):6104.
  • Oncotarget.2015, 6(31):30831-49
  • J Nat Med.2020, 74(3):550-560.
  • ...
  • 生物活性
    Description: Standard reference
    Targets: Antifection
    In vitro:
    Nat Prod Commun. 2012 Apr;7(4):485-6.
    A new diterpene from the leaves of Andrographis paniculata Nees.[Pubmed: 22574448]

    METHODS AND RESULTS:
    Phytochemical investigation of the methanolic extract of the leaves of Andrographis paniculata Nees yielded a minor, new diterpene, 21-nor-3,19-isopropylidine-14-deoxy-ent-labda-8(17),13-dien-16,15-olide (1), together with five known labdane type diterpenes, andrographolide 3, 14-deoxyandrographolide 4, 14-deoxy-12-hydroxyandrographolide 5, 14-deoxy-11,12-dihydroandrographolide 6, neoandrographolide 7, and two acids, cinnamic acid 8, and ferulic acid 9. The chemical structures were established by spectroscopic analyses, including 1D- and 2D-NMR spectroscopic experiments, and on the basis of HR-ESI MS analyses.
    CONCLUSIONS:
    The methanolic extract of the leaves exhibited moderate antibacterial and antifungal activities at a dose of 200 microg/mL in comparison with the reference standards.
    In vivo:
    J Biomed Biotechnol. 2012;2012:876458.
    Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts.[Pubmed: 22536026]
    The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity.
    METHODS AND RESULTS:
    The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-Deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant.
    CONCLUSIONS:
    Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8535 mL 14.2674 mL 28.5347 mL 57.0695 mL 71.3369 mL
    5 mM 0.5707 mL 2.8535 mL 5.7069 mL 11.4139 mL 14.2674 mL
    10 mM 0.2853 mL 1.4267 mL 2.8535 mL 5.7069 mL 7.1337 mL
    50 mM 0.0571 mL 0.2853 mL 0.5707 mL 1.1414 mL 1.4267 mL
    100 mM 0.0285 mL 0.1427 mL 0.2853 mL 0.5707 mL 0.7134 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Andropanolide; Andropanolide CFN97600 869807-57-8 C20H30O5 = 350.45 5mg QQ客服:2159513211
    穿心莲内酯; Andrographolide CFN98923 5508-58-7 C20H30O5 = 350.5 20mg QQ客服:1457312923
    14-去氧-11,12-二去氢穿心莲内酯; 14-Deoxy-11,12-didehydroandrographolide CFN98666 42895-58-9 C20H28O4 = 332.4 20mg QQ客服:2056216494
    脱水穿心莲内酯; Dehydroandrographolide CFN99770 134418-28-3 C20H28O4 = 332.43 20mg QQ客服:215959384
    14-去氧穿心莲内酯; 14-Deoxyandrographolide CFN92802 4176-97-0 C20H30O4 = 334.45 10mg QQ客服:3257982914
    去氧穿心莲内酯; Deoxyandrographolide CFN90518 79233-15-1 C20H30O4 = 334.45 20mg QQ客服:3257982914
    14-去氧基-17-羟基穿心莲内酯; 14-Deoxy-17-hydroxyandrographolide CFN97601 869384-82-7 C20H32O5 = 352.47 5mg QQ客服:3257982914
    14-去氧基-11-羟基穿心莲内酯; 14-Deoxy-11-hydroxyandrographolide CFN97815 160242-09-1 C20H30O5 = 350.45 5mg QQ客服:215959384
    14-去氧-12-羟基穿心莲内酯; 14-Deoxy-12-hydroxyandrographolide CFN97785 219721-33-2 C20H30O5 = 350.45 5mg QQ客服:3257982914
    Vitexolide D; Vitexolide D CFN96446 1788090-69-6 C20H30O3 = 318.45 5mg QQ客服:2056216494

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