14-去氧-12-羟基穿心莲内酯

14-Deoxy-12-hydroxyandrographolide

	产品编号	CFN97785
	CAS编号	219721-33-2
	分子式 = 分子量	C₂₀H₃₀O₅ = 350.45
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The herbs of Andrographis paniculata (Burm. f.) Nees
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
14-去氧-12-羟基穿心莲内酯	CFN97785	219721-33-2	1mg	QQ客服：215959384
14-去氧-12-羟基穿心莲内酯	CFN97785	219721-33-2	5mg	QQ客服：215959384
14-去氧-12-羟基穿心莲内酯	CFN97785	219721-33-2	10mg	QQ客服：215959384
14-去氧-12-羟基穿心莲内酯	CFN97785	219721-33-2	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Chiang Mai University (Thailand)

Shanghai Institute of Biochemistry and Cell Biology (China)

National Hellenic Research Foundation (Greece)

University of Beira Interior (Portugal)

Siksha O Anusandhan University (India)

Auburn University (USA)

Anna University (India)

Universidade da Beira Interior (Germany)

Uniwersytet Medyczny w ?odzi (Poland)

Instituto de Investigaciones Agropecuarias (Chile)

University of Parma (Italy)

University of Melbourne (Australia)

University of Perugia (Italy)

Universidade de Franca (Brazil)

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Description:

Standard reference

Targets:

Antifection

In vitro:

Nat Prod Commun. 2012 Apr;7(4):485-6.

A new diterpene from the leaves of Andrographis paniculata Nees.[Pubmed: 22574448]

METHODS AND RESULTS:
Phytochemical investigation of the methanolic extract of the leaves of Andrographis paniculata Nees yielded a minor, new diterpene, 21-nor-3,19-isopropylidine-14-deoxy-ent-labda-8(17),13-dien-16,15-olide (1), together with five known labdane type diterpenes, andrographolide 3, 14-deoxyandrographolide 4, 14-deoxy-12-hydroxyandrographolide 5, 14-deoxy-11,12-dihydroandrographolide 6, neoandrographolide 7, and two acids, cinnamic acid 8, and ferulic acid 9. The chemical structures were established by spectroscopic analyses, including 1D- and 2D-NMR spectroscopic experiments, and on the basis of HR-ESI MS analyses.
CONCLUSIONS:
The methanolic extract of the leaves exhibited moderate antibacterial and antifungal activities at a dose of 200 microg/mL in comparison with the reference standards.

In vivo:

J Biomed Biotechnol. 2012;2012:876458.

Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts.[Pubmed: 22536026]

The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity.
METHODS AND RESULTS:
The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-Deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant.
CONCLUSIONS:
Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Andropanolide; Andropanolide	CFN97600	869807-57-8	C₂₀H₃₀O₅ = 350.45	5mg	QQ客服：1457312923
穿心莲内酯; Andrographolide	CFN98923	5508-58-7	C₂₀H₃₀O₅ = 350.5	20mg	QQ客服：1413575084
14-去氧-11,12-二去氢穿心莲内酯; 14-Deoxy-11,12-didehydroandrographolide	CFN98666	42895-58-9	C₂₀H₂₈O₄ = 332.4	20mg	QQ客服：215959384
脱水穿心莲内酯; Dehydroandrographolide	CFN99770	134418-28-3	C₂₀H₂₈O₄ = 332.43	20mg	QQ客服：2159513211
14-去氧穿心莲内酯; 14-Deoxyandrographolide	CFN92802	4176-97-0	C₂₀H₃₀O₄ = 334.45	10mg	QQ客服：3257982914
去氧穿心莲内酯; Deoxyandrographolide	CFN90518	79233-15-1	C₂₀H₃₀O₄ = 334.45	20mg	QQ客服：1457312923
14-去氧基-17-羟基穿心莲内酯; 14-Deoxy-17-hydroxyandrographolide	CFN97601	869384-82-7	C₂₀H₃₂O₅ = 352.47	5mg	QQ客服：2159513211
14-去氧基-11-羟基穿心莲内酯; 14-Deoxy-11-hydroxyandrographolide	CFN97815	160242-09-1	C₂₀H₃₀O₅ = 350.45	5mg	QQ客服：3257982914
14-去氧-12-羟基穿心莲内酯; 14-Deoxy-12-hydroxyandrographolide	CFN97785	219721-33-2	C₂₀H₃₀O₅ = 350.45	5mg	QQ客服：2056216494
Vitexolide D; Vitexolide D	CFN96446	1788090-69-6	C₂₀H₃₀O₃ = 318.45	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8535 mL	14.2674 mL	28.5347 mL	57.0695 mL	71.3369 mL
5 mM	0.5707 mL	2.8535 mL	5.7069 mL	11.4139 mL	14.2674 mL
10 mM	0.2853 mL	1.4267 mL	2.8535 mL	5.7069 mL	7.1337 mL
50 mM	0.0571 mL	0.2853 mL	0.5707 mL	1.1414 mL	1.4267 mL
100 mM	0.0285 mL	0.1427 mL	0.2853 mL	0.5707 mL	0.7134 mL