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  • Teuclatriol


    产品编号 CFN99634
    CAS编号 152110-17-3
    分子式 = 分子量 C15H28O3 = 256.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Teucrium leucocladium.
    产品名称 产品编号 CAS编号 包装 QQ客服
    Teuclatriol CFN99634 152110-17-3 1mg QQ客服:2056216494
    Teuclatriol CFN99634 152110-17-3 5mg QQ客服:2056216494
    Teuclatriol CFN99634 152110-17-3 10mg QQ客服:2056216494
    Teuclatriol CFN99634 152110-17-3 20mg QQ客服:2056216494
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  • 生物活性
    Description: Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 312µM and higher. It showed a significant anti-proliferative effect on human activated-peripheral blood lymphocytes (IC50, 72.8 ± 5.4 µg/ml).
    Targets: NF-kB | TNF-α | TLR
    In vitro:
    J Ethnopharmacol. 2015 Feb 3;160:94-100.
    Inhibitory effects of teuclatriol, a sesquiterpene from salvia mirzayanii, on nuclear factor-κB activation and expression of inflammatory mediators.[Pubmed: 25446581]
    Salvia mirzayanii Rech. f. & Esfand. is an endemic plant, which is only distributed in the south of Iran. In traditional Iranian medicine, the aerial parts of Salvia mirzayanii have been used for infections, inflammatory diseases, and as a tonic. From this plant, the sesquiterpene Teuclatriol was isolated by bioactivity-guided fractionation due to its anti-proliferative actions on human lymphocytes. The guaiane sesquiterpene is lacking the methylene-γ-lactone function that is typically involved in the inhibiting properties of sesquiterpenes on NF-κB, a pivotal transcription factor in inflammatory processes. We here investigated anti-inflammatory effects of Teuclatriol on human macrophage-like and endothelial cells.
    Non-toxic doses of Teuclatriol were determined for both cell types by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)-assay. The effect of Teuclatriol on the activity of NF-κB in LPS-stimulated human monocytic THP-1 cells was studied using infrared electrophoretic mobility shift assay (IR-EMSA) using curcumin as positive control (32µM). THP-1 were differentiated into macrophage-like cells and evaluated for TNF-α secretion by L929 bioassay following stimulation with LPS and treatment with Teuclatriol. Inflammatory gene expression in human umbilical vein endothelial cells (HUVEC), modeling target cells for TNF-α-induced inflammatory gene activation, was investigated by real-time RT-PCR.The LPS-induced DNA binding activity of NF-κB in THP-1 was significantly decreased by non-toxic doses of Teuclatriol (312 and 390µM). Teuclatriol reduced the production of TNF-α in a dose-dependent manner. mRNA levels of both monocyte chemoattractant protein (MCP)-1 and toll-like receptor (TLR)2 were decreased in TNF-α-activated HUVEC.
    These data show an inhibitory effect of Teuclatriol on NF-κB signaling at doses of 312µM and higher, validating the traditional use of Salvia mirzayanii in the treatment of inflammatory diseases. Future work on the mode of action of Teuclatriol may provide new lead structures with NF-κB inhibiting properties, lacking possible side effects mediated via alkylating centers of sesquiterpene lactones.
    Iran J Immunol. 2011 Dec;8(4):226-35.
    Immunoinhibitory effect of teuclatriol a guaiane sesquiterpene from Salvia mirzayanii.[Pubmed: 22201620 ]
    Salvia mirzayanii, a native plant to Iran, is shown to have immunomodulatory effects on lymphocyte proliferation. To identify the bioactive immunomodulatory compound(s) present in S. mirzayanii.
    The crude extract was fractionated to five fractions in two steps using different solvents. The fractions were subjected to bioassay-guided fractionation. All the fractions were tested for bioactivity on human activated-peripheral blood lymphocytes (PBLs) using cell proliferation assay. The methanol fraction (Fr. M) showed the highest inhibitory effect on PBLs compared to other fractions. Fr. M was applied on a gravity column chromatography for further fractionation. Resultant fractions, demonstrated inhibitory effects at higher concentrations. Fr. 4 with an 18.9 ± 0.2% inhibitory activity at 200 µg/ml and with the highest quantity was applied on preparative TLC plates for further purification. The final purified compound was identified as Teuclatriol, a guaiane sesquiterpene, by NMR analysis. This compound showed a significant anti-proliferative effect on human activated-peripheral blood lymphocytes (IC50, 72.8 ± 5.4 µg/ml).
    Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii. We suggest further studies on Teuclatriol, exploring its mechanism of action as an immunomodulatory compound.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9002 mL 19.5008 mL 39.0016 mL 78.0031 mL 97.5039 mL
    5 mM 0.78 mL 3.9002 mL 7.8003 mL 15.6006 mL 19.5008 mL
    10 mM 0.39 mL 1.9501 mL 3.9002 mL 7.8003 mL 9.7504 mL
    50 mM 0.078 mL 0.39 mL 0.78 mL 1.5601 mL 1.9501 mL
    100 mM 0.039 mL 0.195 mL 0.39 mL 0.78 mL 0.975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Zedoarondiol; Zedoarondiol CFN92652 98644-24-7 C15H24O3 = 252.4 5mg QQ客服:215959384
    异原莪述烯醇; Isoprocurcumenol CFN92620 102130-90-5 C15H22O2 = 234.3 5mg QQ客服:1413575084
    原莪术烯醇; Procurcumenol CFN92647 21698-40-8 C15H22O2 = 234.3 5mg QQ客服:215959384
    表莪述烯醇; Epiprocurcumenol CFN91614 127214-97-5 C15H22O2 = 234.33 5mg QQ客服:2159513211
    Aerugidiol; Aerugidiol CFN92621 116425-35-5 C15H22O3 = 250.3 5mg QQ客服:2159513211
    新原莪述烯醇; Neoprocurcumenol CFN92789 102130-91-6 C15H22O2 = 234.3 5mg QQ客服:1413575084
    窃衣醇酮; Torilolone CFN96368 13018-09-2 C15H24O3 = 252.4 5mg QQ客服:1457312923
    8-O-乙酰窃衣醇酮; 8-O-Acetyltorilolone CFN96792 20482-21-7 C17H26O4 = 294.39 5mg QQ客服:1413575084
    窃衣素; Torilin CFN96316 13018-10-5 C22H32O5 = 376.5 5mg QQ客服:2159513211
    1alpha-羟基窃衣素; 1alpha-Hydroxytorilin CFN96357 887147-75-3 C22H32O6 = 392.5 5mg QQ客服:1413575084





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