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  • Zedoarondiol

    Zedoarondiol

    Zedoarondiol
    产品编号 CFN92652
    CAS编号 98644-24-7
    分子式 = 分子量 C15H24O3 = 252.4
    产品纯度 >=98%
    物理属性 Solid
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma phaeocaulis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Zedoarondiol CFN92652 98644-24-7 1mg QQ客服:1413575084
    Zedoarondiol CFN92652 98644-24-7 5mg QQ客服:1413575084
    Zedoarondiol CFN92652 98644-24-7 10mg QQ客服:1413575084
    Zedoarondiol CFN92652 98644-24-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Cornell University (USA)
  • Medical University of Gdansk (Poland)
  • Florida International University (USA)
  • Sant Gadge Baba Amravati University (India)
  • Texas A&M University (USA)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Lodz (Poland)
  • Kamphaengphet Rajabhat University (Thailand)
  • Universitas Airlangga (Indonesia)
  • Colorado State University (USA)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Srinakharinwirot University (Thailand)
  • Anna University (India)
  • Imperial College London (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anticancer Res.2018, 38(4):2127-2135
  • J Ethnopharmacol.2020, 254:112733.
  • Processes 2021, 9(5),894.
  • Cancer Manag Res.2019, 11:483-500
  • Nutrients.2018, 10(12):E1998
  • Appl. Sci.2021, 11(24),12080
  • Nat Prod Sci.2019, 25(3):238
  • Phytochem Anal.2023, pca.3305.
  • American Association for Anatomy2020, doi: 10.1002.
  • Neurotox Res.2022, 40(6):1937-1947.
  • Nat Commun.2023, 14(1):4540.
  • J. of The Korean Society of Food Culture2017, 144-149
  • Food Chem.2019, 278:683-691
  • Sci Rep.2018, 8:9267
  • Int Immunopharmacol.2023, 123:110572.
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • Primary and Industrial.2018, 52(11)
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Antioxidants (Basel).2020, 9(2):E99
  • Analytical methods2019, 11(6)
  • Front Immunol.2023, 14:1240800.
  • Vietnam J. Chemistry2022, 60(2):211-222
  • Phytomedicine.2015, 22(4):498-503
  • ...
  • 生物活性
    Description: Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequently inactivating the NF-kappaB pathway. It dose-dependently inhibits LPS-stimulated nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) productions in RAW 264.7 macrophage and in mouse peritoneal macrophage cells.
    Targets: NOS | COX | NF-kB | IkB | NO | PGE | IL Receptor | TNF-α | ERK | p38MAPK | JNK | IKK
    In vitro:
    Int Immunopharmacol. 2009 Aug;9(9):1049-57.
    Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-kappaB pathway in LPS-stimulated murine macrophages.[Pubmed: 19398040 ]
    Several sesquiterpene lactones that have been isolated from medicinal plants are known to have many pharmacological activities.
    METHODS AND RESULTS:
    In this study, we investigated the anti-inflammatory effects of Zedoarondiol, a sesquiterpene lactone isolated from the rhizoma of Curcuma heyneana, in lipopolysaccharide (LPS)-stimulated macrophage cells. Zedoarondiol dose-dependently inhibited LPS-stimulated nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) productions in RAW 264.7 macrophage and in mouse peritoneal macrophage cells. Consistent with these findings, in RAW 264.7 cells, Zedoarondiol suppressed the LPS-stimulated protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and the mRNA expressions of iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta in a concentration-dependent manner. Moreover, molecular data revealed that Zedoarondiol inhibited LPS-stimulated DNA binding activity and the transcription activity of nuclear factor-kappa B (NF-kappaB), and this effect was accompanied by decreases in the degradation and phosphorylation of inhibitory kappaB (IkappaB)-alpha, and in the subsequent blocking of NF-kappaB translocations to the nucleus. Furthermore, Zedoarondiol attenuated the phosphorylations of IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (p38), and c-Jun N-terminal kinase (JNK) in LPS-stimulated RAW 264.7 cells.
    CONCLUSIONS:
    Taken together, the findings of the present study indicate that Zedoarondiol inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequently inactivating the NF-kappaB pathway. These relations reveal, in part, the mechanism underlying the anti-inflammatory properties of Zedoarondiol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.962 mL 19.8098 mL 39.6197 mL 79.2393 mL 99.0491 mL
    5 mM 0.7924 mL 3.962 mL 7.9239 mL 15.8479 mL 19.8098 mL
    10 mM 0.3962 mL 1.981 mL 3.962 mL 7.9239 mL 9.9049 mL
    50 mM 0.0792 mL 0.3962 mL 0.7924 mL 1.5848 mL 1.981 mL
    100 mM 0.0396 mL 0.1981 mL 0.3962 mL 0.7924 mL 0.9905 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    苍术苷A; Atractyloside A CFN98560 126054-77-1 C21H36O10 = 448.5 20mg QQ客服:3257982914
    Isonardoperoxide; Isonardoperoxide CFN89350 205248-65-3 C15H22O4 = 266.33 5mg QQ客服:1413575084
    Orobanone; Orobanone CFN92654 78916-35-5 C15H20O = 216.3 5mg QQ客服:2159513211
    Zedoarondiol; Zedoarondiol CFN92652 98644-24-7 C15H24O3 = 252.4 5mg QQ客服:215959384
    异原莪述烯醇; Isoprocurcumenol CFN92620 102130-90-5 C15H22O2 = 234.3 5mg QQ客服:2056216494
    原莪术烯醇; Procurcumenol CFN92647 21698-40-8 C15H22O2 = 234.3 5mg QQ客服:3257982914
    表莪述烯醇; Epiprocurcumenol CFN91614 127214-97-5 C15H22O2 = 234.33 5mg QQ客服:1457312923
    Aerugidiol; Aerugidiol CFN92621 116425-35-5 C15H22O3 = 250.3 5mg QQ客服:1413575084
    新原莪述烯醇; Neoprocurcumenol CFN92789 102130-91-6 C15H22O2 = 234.3 5mg QQ客服:215959384
    窃衣醇酮; Torilolone CFN96368 13018-09-2 C15H24O3 = 252.4 5mg QQ客服:1413575084

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