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  • Zedoarondiol

    Zedoarondiol

    Zedoarondiol
    产品编号 CFN92652
    CAS编号 98644-24-7
    分子式 = 分子量 C15H24O3 = 252.4
    产品纯度 >=98%
    物理属性 Solid
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma phaeocaulis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Zedoarondiol CFN92652 98644-24-7 1mg QQ客服:2159513211
    Zedoarondiol CFN92652 98644-24-7 5mg QQ客服:2159513211
    Zedoarondiol CFN92652 98644-24-7 10mg QQ客服:2159513211
    Zedoarondiol CFN92652 98644-24-7 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Oslo (Norway)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Pennsylvania State University (USA)
  • Kyoto University (Japan)
  • University of Dicle (Turkey)
  • National Cancer Center Research Institute (Japan)
  • Florida International University (USA)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Hull (United Kingdom)
  • Nanjing University of Chinese Medicine (China)
  • Worcester Polytechnic Institute (USA)
  • Max-Planck-Insitut (Germany)
  • University of Pretoria (South Africa)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tumour Biol.2015, 36(9):7027-34
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Korean J. Food Sci. & Technol.2022, 54(2):241-246
  • Molecules. 2013, 18(7):7376-88
  • Sci Rep.2021, 11(1):11936.
  • LWT2020, 110397
  • Kor. J. Herbol.2019, 34(2):59-66
  • Microchemical Journal2018, 137:168-173
  • The Korea Society of Pha.2014, 300-314
  • Arch Toxicol.2017, 91(10):3225-3245
  • Front Pharmacol.2019, 10:1226
  • Phytother Res.2016, 30(12):2020-2026
  • Food Sci Nutr.2019, 8(1):246-256
  • Foods.2020, 9(10):1348.
  • J Biomol Struct Dyn.2022, 5;1-17.
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Curr Res Virol Sci.2022, 3:100019.
  • Anal Chim Acta.2021, 1180:338874.
  • Eur J Pharm Sci.2016, 94:33-45
  • Int J Mol Sci.2019, 20(21):E5488
  • Front Plant Sci.2017, 8:723
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Front Plant Sci.2022, 13: 905275.
  • ...
  • 生物活性
    Description: Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequently inactivating the NF-kappaB pathway. It dose-dependently inhibits LPS-stimulated nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) productions in RAW 264.7 macrophage and in mouse peritoneal macrophage cells.
    Targets: NOS | COX | NF-kB | IkB | NO | PGE | IL Receptor | TNF-α | ERK | p38MAPK | JNK | IKK
    In vitro:
    Int Immunopharmacol. 2009 Aug;9(9):1049-57.
    Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-kappaB pathway in LPS-stimulated murine macrophages.[Pubmed: 19398040 ]
    Several sesquiterpene lactones that have been isolated from medicinal plants are known to have many pharmacological activities.
    METHODS AND RESULTS:
    In this study, we investigated the anti-inflammatory effects of Zedoarondiol, a sesquiterpene lactone isolated from the rhizoma of Curcuma heyneana, in lipopolysaccharide (LPS)-stimulated macrophage cells. Zedoarondiol dose-dependently inhibited LPS-stimulated nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) productions in RAW 264.7 macrophage and in mouse peritoneal macrophage cells. Consistent with these findings, in RAW 264.7 cells, Zedoarondiol suppressed the LPS-stimulated protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and the mRNA expressions of iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta in a concentration-dependent manner. Moreover, molecular data revealed that Zedoarondiol inhibited LPS-stimulated DNA binding activity and the transcription activity of nuclear factor-kappa B (NF-kappaB), and this effect was accompanied by decreases in the degradation and phosphorylation of inhibitory kappaB (IkappaB)-alpha, and in the subsequent blocking of NF-kappaB translocations to the nucleus. Furthermore, Zedoarondiol attenuated the phosphorylations of IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (p38), and c-Jun N-terminal kinase (JNK) in LPS-stimulated RAW 264.7 cells.
    CONCLUSIONS:
    Taken together, the findings of the present study indicate that Zedoarondiol inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequently inactivating the NF-kappaB pathway. These relations reveal, in part, the mechanism underlying the anti-inflammatory properties of Zedoarondiol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.962 mL 19.8098 mL 39.6197 mL 79.2393 mL 99.0491 mL
    5 mM 0.7924 mL 3.962 mL 7.9239 mL 15.8479 mL 19.8098 mL
    10 mM 0.3962 mL 1.981 mL 3.962 mL 7.9239 mL 9.9049 mL
    50 mM 0.0792 mL 0.3962 mL 0.7924 mL 1.5848 mL 1.981 mL
    100 mM 0.0396 mL 0.1981 mL 0.3962 mL 0.7924 mL 0.9905 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    莪术醇; Curcumenol CFN92614 19431-84-6 C15H22O2 = 234.3 20mg QQ客服:2056216494
    异莪术醇; Isocurcumenol CFN92618 24063-71-6 C15H22O2 = 234.3 20mg QQ客服:1457312923
    莪术醇; 姜黄醇; Curcumol CFN99187 4871-97-0 C15H24O2 = 236.35 20mg QQ客服:2056216494
    4beta,12-dihydroxyguaian-6,10-diene; 4beta,12-dihydroxyguaian-6,10-diene CFN90947 461644-90-6 C15H24O2 = 236.34 5mg QQ客服:2056216494
    Chrysothol; Chrysothol CFN97477 911714-91-5 C15H26O2 = 238.4 5mg QQ客服:2159513211
    泽泻醇; Alismol CFN97446 87827-55-2 C15H24O = 220.4 10mg QQ客服:2159513211
    环氧泽泻烯; Alismoxide CFN99775 87701-68-6 C15H26O2 = 238.37 20mg QQ客服:2056216494
    愈创醇; Guaiol CFN96326 489-86-1 C15H26O = 222.4 5mg QQ客服:2056216494
    Teuclatriol; Teuclatriol CFN99634 152110-17-3 C15H28O3 = 256.4 5mg QQ客服:3257982914
    苍术苷A; Atractyloside A CFN98560 126054-77-1 C21H36O10 = 448.5 20mg QQ客服:2056216494

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