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  • 环氧泽泻烯

    Alismoxide

    环氧泽泻烯
    产品编号 CFN99775
    CAS编号 87701-68-6
    分子式 = 分子量 C15H26O2 = 238.37
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The tubers of Alisma plantago-aquatica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    环氧泽泻烯 CFN99775 87701-68-6 10mg QQ客服:1457312923
    环氧泽泻烯 CFN99775 87701-68-6 20mg QQ客服:1457312923
    环氧泽泻烯 CFN99775 87701-68-6 50mg QQ客服:1457312923
    环氧泽泻烯 CFN99775 87701-68-6 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kazusa DNA Research Institute (Japan)
  • Regional Crop Research Institute (Korea)
  • University of Auckland (New Zealand)
  • Chinese University of Hong Kong (China)
  • University of Hawaii Cancer Center (USA)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Monash University (Australia)
  • Julius Kühn-Institut (Germany)
  • University of the Basque Country (Spain)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • CSIRO - Agriculture Flagship (Australia)
  • University of Pretoria (South Africa)
  • Kyoto University (Japan)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Asian Nat Prod Res.2019, 5:1-17
  • Biomed Chromatogr.2022, 36(11):e5462.
  • Anal Bioanal Chem.2016, 408(1):177-90.
  • Molecules 2022, 27(3),960.
  • Molecules.2022, 27(2):451.
  • Phytother Res.2020, 34(4):788-795.
  • PLoS One.2018, 13(4):e0195642
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • J Biochem Mol Toxicol.2017, 31(9)
  • Asian Journal of Chemistry2014, 26(8):2425
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • BMC Complement Altern Med.2014, 14:242
  • International. J. of Food Properties 2017, 20:S131-S140
  • J Biomol Struct Dyn.2022, 1-21.
  • Journal of Food Composition and Analysis2021, 100:103905.
  • Pharmaceuticals (Basel). 2021, 14(10):986.
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Neurotox Res.2020, 38(1):163-174.
  • Sci Rep.2021, 11(1):14180.
  • J Pharm Anal.2016, 6(6):363-373
  • Nutrients.2021, 13(1):254.
  • Phytother Res.2022, 10.1002:ptr.7626.
  • ...
  • 生物活性
    Description: Alismoxide shows an inhibitory effect on the contraction of isolated bladder smooth muscle induced by carbachol; it demonstrates cytostatic action in HeLa cells, revealing potential use in virostatic cocktails. Alismoxide has inhibitory effects on vascular contraction induced by high concentration of KCl; it also shows an inhibitory effect on the direct passive Arthus reaction (DPAR) in rats in the type III allergic model.
    Targets: NO
    In vitro:
    Mar Drugs. 2013 Dec 10;11(12):4917-36.
    Cytotoxic, cytostatic and HIV-1 PR inhibitory activities of the soft coral Litophyton arboreum.[Pubmed: 24336129]
    Bioassay-guided fractionation using different chromatographic and spectroscopic techniques in the analysis of the Red Sea soft coral Litophyton arboreum led to the isolation of nine compounds; sarcophytol M (1), alismol (2), 24-methylcholesta-5,24(28)-diene-3β-ol (3), 10-O-methyl alismoxide (4), alismoxide (5), (S)-chimyl alcohol (6), 7β-acetoxy-24-methylcholesta-5-24(28)-diene-3,19-diol (7), erythro-N-dodecanoyl-docosasphinga-(4E,8E)-dienine (8), and 24-methylcholesta-5,24 (28)-diene-3β,7β,19-triol (9).
    METHODS AND RESULTS:
    Some of the isolated compounds demonstrated potent cytotoxic- and/or cytostatic activity against HeLa and U937 cancer cell lines and inhibitory activity against HIV-1 protease (PR). Compound 7 was strongly cytotoxic against HeLa cells (CC₅₀ 4.3 ± 0.75 µM), with selectivity index of SI 8.1, which was confirmed by real time cell electronic sensing (RT-CES). Compounds 2, 7, and 8 showed strong inhibitory activity against HIV-1 PR at IC₅₀s of 7.20 ± 0.7, 4.85 ± 0.18, and 4.80 ± 0.92 µM respectively. In silico docking of most compounds presented comparable scores to that of acetyl pepstatin, a known HIV-1 PR inhibitor. Interestingly, compound 8 showed potent HIV-1 PR inhibitory activity in the absence of cytotoxicity against the cell lines used. In addition, compounds 2 and 5 demonstrated cytostatic action in HeLa cells, revealing potential use in virostatic cocktails.
    CONCLUSIONS:
    Taken together, data presented here suggest Litophyton arboreum to contain promising compounds for further investigation against the diseases mentioned.
    In vivo:
    Biol Pharm Bull. 1997 May;20(5):511-6.
    Studies on Alismatis rhizoma. I. Anti-allergic effects of methanol extract and six terpene components from Alismatis rhizoma (dried rhizome of Alisma orientale).[Pubmed: 9178931]
    Methanol and aqueous extracts (TMe-ext and TAq-ext) from dried rhizomes of Alisma orientale have been screened for activity in experimental models of type I-IV allergies.
    METHODS AND RESULTS:
    In the type III allergic model, TMe-ext at oral doses of 50, 200 mg/kg showed an inhibitory effect on the direct passive Arthus reaction (DPAR) in rats, while TAq-ext did not. Four triterpenes (alisol A, alisol B, alisol A monoacetate and alisol B monoacetate) and two sesquiterpenes (alismol and Alismoxide) isolated from TMe-ext also exhibited this inhibitory effect. In a type I allergic model, TMe-ext inhibited 48-h homologous passive cutaneous anaphylaxis (PCA) in rats. In a type II allergic model, it was found that TMe-ext inhibits reversed cutaneous anaphylaxis (RCA) in rats. Furthermore, in a type IV allergic model, TMe-ext had an inhibitory effect on the induction phase in picryl chloride-induced contact dermatitis (PC-CD) in mice.
    CONCLUSIONS:
    These results indicate that Alismatis Rhizoma not only inhibits antibody-mediated allergic reactions but also influences cell reactions and should be recognized as a material for the treatment of allergic reactions, and the anti-type III allergic components are partially attributable to the terpenes mentioned above.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1952 mL 20.9758 mL 41.9516 mL 83.9032 mL 104.879 mL
    5 mM 0.839 mL 4.1952 mL 8.3903 mL 16.7806 mL 20.9758 mL
    10 mM 0.4195 mL 2.0976 mL 4.1952 mL 8.3903 mL 10.4879 mL
    50 mM 0.0839 mL 0.4195 mL 0.839 mL 1.6781 mL 2.0976 mL
    100 mM 0.042 mL 0.2098 mL 0.4195 mL 0.839 mL 1.0488 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新原莪述烯醇; Neoprocurcumenol CFN92789 102130-91-6 C15H22O2 = 234.3 5mg QQ客服:2159513211
    窃衣醇酮; Torilolone CFN96368 13018-09-2 C15H24O3 = 252.4 5mg QQ客服:3257982914
    8-O-乙酰窃衣醇酮; 8-O-Acetyltorilolone CFN96792 20482-21-7 C17H26O4 = 294.39 5mg QQ客服:3257982914
    窃衣素; Torilin CFN96316 13018-10-5 C22H32O5 = 376.5 5mg QQ客服:2056216494
    1alpha-羟基窃衣素; 1alpha-Hydroxytorilin CFN96357 887147-75-3 C22H32O6 = 392.5 5mg QQ客服:215959384
    1beta-羟基窃衣素; 1beta-Hydroxytorilin CFN96793 509078-16-4 C22H32O6 = 392.49 5mg QQ客服:215959384
    苏葛三醇 6,9-二乙酸酯; Sugetriol 6,9-diacetate CFN96652 17928-63-1 C19H28O5 = 336.43 5mg QQ客服:2159513211
    莪术醇; Curcumenol CFN92614 19431-84-6 C15H22O2 = 234.3 20mg QQ客服:2159513211
    异莪术醇; Isocurcumenol CFN92618 24063-71-6 C15H22O2 = 234.3 20mg QQ客服:3257982914
    莪术醇; 姜黄醇; Curcumol CFN99187 4871-97-0 C15H24O2 = 236.35 20mg QQ客服:3257982914

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