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  • 泽泻醇

    Alismol

    泽泻醇
    产品编号 CFN97446
    CAS编号 87827-55-2
    分子式 = 分子量 C15H24O = 220.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The tubers of Alisma plantago-aquatica Linn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    泽泻醇 CFN97446 87827-55-2 1mg QQ客服:1457312923
    泽泻醇 CFN97446 87827-55-2 5mg QQ客服:1457312923
    泽泻醇 CFN97446 87827-55-2 10mg QQ客服:1457312923
    泽泻醇 CFN97446 87827-55-2 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • University of Liège (Belgium)
  • Kitasato University (Japan)
  • University of Indonesia (Indonesia)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
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  • Funda??o Universitária de Desenvolvimento (Brazil)
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  • University of Oslo (Norway)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • Mediators Inflamm. 2016, 2016:6189590
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  • ...
  • 生物活性
    Description: Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. Alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release. Alismol has inhibitory effect to MMP3 expression and nitric oxide produced in microglial cells. It holds great promise for use in chemopreventive and chemotherapeutic strategies.
    Targets: Calcium Channel | Potassium Channel | PI3K | Akt | ERK | JNK | Caspase | MMP(e.g.TIMP)
    In vitro:
    Jpn J Pharmacol. 1988 Apr;46(4):331-5.
    Effect of alismol on adrenergic mechanism in isolated rabbit ear artery.[Pubmed: 3404764 ]
    Effects of alismol, a sesquiterpenoid isolated from the rhyzome of Alisma orientale, on adrenergic mechanisms were examined in the isolated rabbit ear artery.
    METHODS AND RESULTS:
    Alismol (10(-6) to 10(-4) M) inhibited the contraction of isolated rabbit ear artery by electrical stimulation of the perivascular nerves. The inhibition was concentration-dependent; at a concentration of 10(-4) M, the inhibition was 90% (n = 8). Treatment with 10(-4) M alismol inhibited the increase in 3H-noradrenaline (3H-NAd) release induced by electrical stimulation by 63 +/- 6%. Alismol at 10(-4) M did not affect the neuronal uptake of 3H-NAd in the artery. Alismol at 10(-4) M slightly inhibited contractions induced by exogenously administered NAd.
    CONCLUSIONS:
    These results demonstrate that alismol inhibits the adrenergic neuro-effector mechanisms in rabbit ear artery, and they suggest that alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release.
    Life Sci. 1987 Oct 12;41(15):1845-52.
    Effects of alismol isolated from Alismatis Rhizoma on calcium-induced contraction in the rabbit thoracic aorta.[Pubmed: 3657386]

    METHODS AND RESULTS:
    We examined the inhibitory effects of alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, on vascular contractions induced by high concentrations of K+ and Ca2+, and on 45Ca2+ retention in normal and in high K+-containing medium. Alismol affected neither the resting tension nor the 45Ca2+ retention in normal medium, but it inhibited sustained contraction and increased 45Ca2+ retention induced by high K+ concentrations. Alismol did not affect norepinephrine-induced contractions in normal medium, nor phasic contractions in Ca2+-free medium.
    CONCLUSIONS:
    These results suggested that alismol inhibited mainly Ca2+ influx through a voltage-dependent Ca2+ channel.
    Phytother. Res., 1989, 3(2):72-4.
    Effect of alismol isolated from Alismatis Rhizoma on working heart perfusion in rat.[Reference: WebLink]

    METHODS AND RESULTS:
    The effect of Alismol (Oshima et al., 1983), a sesquiterpenoid isolated from Alismatis Rhizoma which is used as a Chinese crude drug, was studied on rat isolated heart using the working heart perfusion technique. Alismol decreased cardiac output, heart rate and left ventricular pressure, but it increased coronary flow.
    CONCLUSIONS:
    The drug has been used for the prevention of anginal attacks and our results provide a pharmacological basis for one of the traditional medicinal effects of Alismatis Rhizoma.
    In vivo:
    Phytother. Res., 1989, 3(2):57-60.
    The effect of alismol isolated from Alismatis Rhizoma on experimental hypertensive models in rats.[Reference: WebLink]

    METHODS AND RESULTS:
    The antihypertensive action of Alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, the rhizome of Alisma orientale Juzepczuk (Alismataceae), was examined in various experimental hypertensive models in rats and the effect of Alismol on the activation of plasma renin, angiotensin-converting enzyme (ACE) and the level of aldosterone were examined in 2-kidney, 1-clip hypertensive model.
    CONCLUSIONS:
    Alismol caused a sustained, though weak, antihypertensive action in all the experimental models, but did not significantly affect the plasma renin activity, ACE activity and the level of aldosterone.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5372 mL 22.686 mL 45.3721 mL 90.7441 mL 113.4301 mL
    5 mM 0.9074 mL 4.5372 mL 9.0744 mL 18.1488 mL 22.686 mL
    10 mM 0.4537 mL 2.2686 mL 4.5372 mL 9.0744 mL 11.343 mL
    50 mM 0.0907 mL 0.4537 mL 0.9074 mL 1.8149 mL 2.2686 mL
    100 mM 0.0454 mL 0.2269 mL 0.4537 mL 0.9074 mL 1.1343 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-O-乙酰窃衣醇酮; 8-O-Acetyltorilolone CFN96792 20482-21-7 C17H26O4 = 294.39 5mg QQ客服:1413575084
    窃衣素; Torilin CFN96316 13018-10-5 C22H32O5 = 376.5 5mg QQ客服:215959384
    1alpha-羟基窃衣素; 1alpha-Hydroxytorilin CFN96357 887147-75-3 C22H32O6 = 392.5 5mg QQ客服:215959384
    1beta-羟基窃衣素; 1beta-Hydroxytorilin CFN96793 509078-16-4 C22H32O6 = 392.49 5mg QQ客服:2056216494
    苏葛三醇 6,9-二乙酸酯; Sugetriol 6,9-diacetate CFN96652 17928-63-1 C19H28O5 = 336.43 5mg QQ客服:1457312923
    莪术醇; Curcumenol CFN92614 19431-84-6 C15H22O2 = 234.3 20mg QQ客服:2159513211
    异莪术醇; Isocurcumenol CFN92618 24063-71-6 C15H22O2 = 234.3 20mg QQ客服:215959384
    莪术醇; 姜黄醇; Curcumol CFN99187 4871-97-0 C15H24O2 = 236.35 20mg QQ客服:2056216494
    4beta,12-dihydroxyguaian-6,10-diene; 4beta,12-dihydroxyguaian-6,10-diene CFN90947 461644-90-6 C15H24O2 = 236.34 5mg QQ客服:3257982914
    Chrysothol; Chrysothol CFN97477 911714-91-5 C15H26O2 = 238.4 5mg QQ客服:1457312923

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