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  • 异莪术醇

    Isocurcumenol

    异莪术醇
    产品编号 CFN92618
    CAS编号 24063-71-6
    分子式 = 分子量 C15H22O2 = 234.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma wenyujin Y.H.Chen et C.Ling.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异莪术醇 CFN92618 24063-71-6 10mg QQ客服:215959384
    异莪术醇 CFN92618 24063-71-6 20mg QQ客服:215959384
    异莪术醇 CFN92618 24063-71-6 50mg QQ客服:215959384
    异莪术醇 CFN92618 24063-71-6 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mendel University in Brno (Czech Republic)
  • University of Maryland School of Medicine (USA)
  • Agricultural Research Organization (ARO) (Israel)
  • University of Hull (United Kingdom)
  • Universite de Lille1 (France)
  • Imperial College London (United Kingdom)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Universidade Federal de Santa Catarina (Brazil)
  • Florida International University (USA)
  • University of Oslo (Norway)
  • University of Toulouse (France)
  • Universidad Miguel Hernández (Spain)
  • FORTH-IMBB (Greece)
  • Istanbul University (Turkey)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2017, 7:467-479
  • Eur Endod J.2020, 5(1):23-27.
  • Plant Physiol.2023, 193(3):1758-1771.
  • Environ Toxicol.2023, 38(7):1641-1650.
  • Bioorg Med Chem.2020, 28(12):115553.
  • Food Chem.2018, 262:78-85
  • Mol Med Rep.2022, 25(1):8.
  • Drug Chem Toxicol.2024, 1-10.
  • Chem Biol Interact.2022, 368:110248.
  • BMC Complement Altern Med.2019, 19(1):367
  • Acta Edulis Fungi2020, 27(02):63-76.
  • Plant Cell, Tissue and Organ Culture (PCTOC)2020, 143, 45-60(2020)
  • Molecules.2019, 24(11):E2102
  • J Food Composition and Analysis2022, 104417.
  • Int J Pharm.2022, 618:121636.
  • Pharmacognosy Journal, 2021, 13(5).
  • Applied Biological Chemistry2021, 64(4)
  • New Zealand J. Forestry Sci.2014, 44:17
  • Curr Med Sci.2024, 44(2):355-368.
  • Food Bioscience2023, 59:103903
  • J Clin Transl Hepatol.2023, 11(4):863-876.
  • Sci Rep. 2017, 17332(7)
  • Enzyme Microb Technol.2022, 153:109941.
  • ...
  • 生物活性
    Description: Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).
    Targets: 5α-Reductase
    In vivo:
    Fitoterapia. 2012 Jul;83(5):864-71.
    Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb.[Pubmed: 22465508]

    METHODS AND RESULTS:
    Six sesquiterpenes: germacrone (1), zederone (2), dehydrocurdione (3), curcumenol (4), zedoarondiol (5) and isocurcumenol (6) were isolated from rhizomes of Curcuma aeruginosa Roxb. (Zingiberaceae). They inhibited 5α-reductase which converts testosterone to dihydrotestosterone (DHT). Germacrone (1) was the most potent (IC(50)=0.42±0.05 mg/mL). Compound 1 was anti-androgenic in LNCaP cells when proliferation was testosterone-induced. The growth of flank gland of male Syrian hamsters is dependent on circulating androgen and when maintained with testosterone, 1 (3, 30, 100μg) inhibited growth but was ineffective against DHT. The similar activity profile was observed on the 5α-reductase inhibitor, finasteride (100 μg) treatment group. The androgen receptor binding assay showed that 1 did not bind to the androgen receptor.
    CONCLUSIONS:
    In conclusion, 1 showed anti-androgenic effect on in vitro and in vivo assays. One of the possible mechanisms was inhibition 5α-reductase activity. Thus, 1 is a potential lead compound for treatment of androgen-dependent disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Chrysothol; Chrysothol CFN97477 911714-91-5 C15H26O2 = 238.4 5mg QQ客服:2056216494
    泽泻醇; Alismol CFN97446 87827-55-2 C15H24O = 220.4 10mg QQ客服:215959384
    环氧泽泻烯; Alismoxide CFN99775 87701-68-6 C15H26O2 = 238.37 20mg QQ客服:215959384
    愈创醇; Guaiol CFN96326 489-86-1 C15H26O = 222.4 5mg QQ客服:2056216494
    Teuclatriol; Teuclatriol CFN99634 152110-17-3 C15H28O3 = 256.4 5mg QQ客服:1413575084
    苍术苷A; Atractyloside A CFN98560 126054-77-1 C21H36O10 = 448.5 20mg QQ客服:2159513211
    Isonardoperoxide; Isonardoperoxide CFN89350 205248-65-3 C15H22O4 = 266.33 5mg QQ客服:2159513211
    Orobanone; Orobanone CFN92654 78916-35-5 C15H20O = 216.3 5mg QQ客服:3257982914
    Zedoarondiol; Zedoarondiol CFN92652 98644-24-7 C15H24O3 = 252.4 5mg QQ客服:2159513211
    异原莪述烯醇; Isoprocurcumenol CFN92620 102130-90-5 C15H22O2 = 234.3 5mg QQ客服:2159513211

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