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  • 异莪术醇

    Isocurcumenol

    异莪术醇
    产品编号 CFN92618
    CAS编号 24063-71-6
    分子式 = 分子量 C15H22O2 = 234.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma wenyujin Y.H.Chen et C.Ling.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    异莪术醇 CFN92618 24063-71-6 10mg QQ客服:2056216494
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    异莪术醇 CFN92618 24063-71-6 50mg QQ客服:2056216494
    异莪术醇 CFN92618 24063-71-6 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chiang Mai University (Thailand)
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  • Institute of Chinese Materia Medica (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Communications2018, 10.1177
  • Acta Chromatographica2021, 00960.
  • Primary and Industrial.2018, 52(11)
  • Biomolecules.2019, 9(11):E696
  • Food Funct.2022, doi: 10.1039
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • University of Stuttgart2021, 11682.
  • Plos One.2019, 15(2):e0220084
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • J Appl Biol Chem.2022, 65(4):pp.463-469.
  • Nutraceuticals2022, 2(3),150-161
  • Pharmaceutics.2022, 14(12):2765.
  • Food Chem.2019, 278:683-691
  • Plants (Basel).2021, 10(11):2317.
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Sci Rep.2017, 7:40345
  • J Pharm Pharmacol.2022, rgac033.
  • Chem Biol Interact.2018, 290:44-51
  • Front. Pharmacol.2022, 901563.
  • J Adv Res.2019, 17:85-94
  • Molecules.2021, 26(6):1738.
  • Molecules 2022, 27(3),1047.
  • Plants (Basel).2023, 12(1):163.
  • ...
  • 生物活性
    Description: Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).
    Targets: 5α-Reductase
    In vivo:
    Fitoterapia. 2012 Jul;83(5):864-71.
    Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb.[Pubmed: 22465508]

    METHODS AND RESULTS:
    Six sesquiterpenes: germacrone (1), zederone (2), dehydrocurdione (3), curcumenol (4), zedoarondiol (5) and isocurcumenol (6) were isolated from rhizomes of Curcuma aeruginosa Roxb. (Zingiberaceae). They inhibited 5α-reductase which converts testosterone to dihydrotestosterone (DHT). Germacrone (1) was the most potent (IC(50)=0.42±0.05 mg/mL). Compound 1 was anti-androgenic in LNCaP cells when proliferation was testosterone-induced. The growth of flank gland of male Syrian hamsters is dependent on circulating androgen and when maintained with testosterone, 1 (3, 30, 100μg) inhibited growth but was ineffective against DHT. The similar activity profile was observed on the 5α-reductase inhibitor, finasteride (100 μg) treatment group. The androgen receptor binding assay showed that 1 did not bind to the androgen receptor.
    CONCLUSIONS:
    In conclusion, 1 showed anti-androgenic effect on in vitro and in vivo assays. One of the possible mechanisms was inhibition 5α-reductase activity. Thus, 1 is a potential lead compound for treatment of androgen-dependent disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    窃衣醇酮; Torilolone CFN96368 13018-09-2 C15H24O3 = 252.4 5mg QQ客服:2159513211
    8-O-乙酰窃衣醇酮; 8-O-Acetyltorilolone CFN96792 20482-21-7 C17H26O4 = 294.39 5mg QQ客服:3257982914
    窃衣素; Torilin CFN96316 13018-10-5 C22H32O5 = 376.5 5mg QQ客服:1457312923
    1alpha-羟基窃衣素; 1alpha-Hydroxytorilin CFN96357 887147-75-3 C22H32O6 = 392.5 5mg QQ客服:1457312923
    1beta-羟基窃衣素; 1beta-Hydroxytorilin CFN96793 509078-16-4 C22H32O6 = 392.49 5mg QQ客服:215959384
    苏葛三醇 6,9-二乙酸酯; Sugetriol 6,9-diacetate CFN96652 17928-63-1 C19H28O5 = 336.43 5mg QQ客服:2159513211
    莪术醇; Curcumenol CFN92614 19431-84-6 C15H22O2 = 234.3 20mg QQ客服:1457312923
    异莪术醇; Isocurcumenol CFN92618 24063-71-6 C15H22O2 = 234.3 20mg QQ客服:1457312923
    莪术醇; 姜黄醇; Curcumol CFN99187 4871-97-0 C15H24O2 = 236.35 20mg QQ客服:1457312923
    4beta,12-dihydroxyguaian-6,10-diene; 4beta,12-dihydroxyguaian-6,10-diene CFN90947 461644-90-6 C15H24O2 = 236.34 5mg QQ客服:215959384

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