灵芝醇F

Ganoderiol F

	产品编号	CFN99244
	CAS编号	114567-47-4
	分子式 = 分子量	C₃₀H₄₆O₃ = 454.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The fruit body of Ganoderma lucidum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
灵芝醇F	CFN99244	114567-47-4	1mg	QQ客服：1457312923
灵芝醇F	CFN99244	114567-47-4	5mg	QQ客服：1457312923
灵芝醇F	CFN99244	114567-47-4	10mg	QQ客服：1457312923
灵芝醇F	CFN99244	114567-47-4	20mg	QQ客服：1457312923

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

Description:

Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced HO-1 expression, activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 and suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production.

Targets:

Androgen Receptor | HIV | NO | HO-1

In vitro:

Toxicol Appl Pharmacol. 2014 Nov 1;280(3):434-42.

Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells.[Pubmed: 25239868]

Ganoderma lucidum is a popular medicinal mushroom used in traditional medicine for preventing or treating a variety of diseases.
METHODS AND RESULTS:
In the present study, we investigated the anti-inflammatory and heme oxygenase (HO)-1 inducing effects of 12 lanostane triterpenes from G. lucidum in RAW264.7 cells. Of these, seven triterpenes, butyl lucidenateE2, butyl lucidenateD2 (GT-2), butyl lucidenate P, butyl lucidenateQ, Ganoderiol F, methyl ganodenate J and butyl lucidenate N induced HO-1 expression and suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Inhibiting HO-1 activity abrogated the inhibitory effects of these triterpenes on the production of NO in LPS-stimulated RAW264.7 cells, suggesting the involvement of HO-1 in the anti-inflammatory effects of these triterpenes. We further studied the anti-inflammatory and HO-1 inducing effects of GT-2. Mitogen-activated protein kinase inhibitors or N-acetylcysteine, an antioxidant, did not suppress GT-2-mediated HO-1 induction; however, LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, blocked GT-2-induced HO-1 mRNA and protein expression. GT-2 increased nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) and knockdown of Nrf2 by small interfering RNA blocked GT-2-mediated HO-1 induction, suggesting that GT-2 induced HO-1 expression via the PI3K/AKT-Nrf2 pathway. Consistent with the notion that HO-1 has anti-inflammatory properties, GT-2 inhibited the production of tumor necrosis factor-α and interleukin-6, as well as inducible nitric oxide synthase and cyclooxygenase-2 expression.
CONCLUSIONS:
These findings suggest that HO-1 inducing activities of these lanostane triterpenes may be important in the understanding of a novel mechanism for the anti-inflammatory activity of G. lucidum.

In vivo:

Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1076-80.

Anti-human immunodeficiency virus-1 protease activity of new lanostane-type triterpenoids from Ganoderma sinense.[Pubmed: 19801861]

Five new highly oxygenated lanostane-type triterpenoids [ganoderic acid GS-1 (1), ganoderic acid GS-2 (2), ganoderic acid GS-3 (3), 20(21)-dehydrolucidenic acid N (4) and 20-hydroxylucidenic acid A (5)] were isolated from the fruiting body of Ganoderma sinense, together with known compounds including 6 triterpenoids and 3 sterols.
METHODS AND RESULTS:
The structures of the new triterpenoids determined by spectroscopic means including 2D NMR were 7beta-hydroxy-3,11,15-trioxo-lanosta-8,24(E)-dien-26-oic acid (1), 7beta,15alpha-dihydroxy-3,11-dioxo-lanosta-8,24(E)-dien-26-oic acid (2), 12beta-acetoxy-3beta,7beta-dihydroxy-11,15-dioxo-lanosta-8,24(E)-dien-26-oic acid (3), 3beta,7beta-dihydroxy-11,15-dioxo-25,26,27-trinorlanosta-8,20-dien-24-oic acid (4), and 7beta,20xi-dihydroxy-3,11,15-trioxo-25,26,27-trinorlanost-8-en-24-oic acid (5), respectively.
CONCLUSIONS:
Among these, ganoderic acid GS-2, 20-hydroxylucidenic acid N, 20(21)-dehydrolucidenic acid N and ganoderiol F inhibited human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
灵芝萜酮二醇 ; Ganodermanondiol	CFN99085	107900-76-5	C₃₀H₄₈O₃ = 456.7	5mg	QQ客服：1457312923
灵芝醇A; Ganoderiol A	CFN80461	106518-61-0	C₃₀H₅₀O₄ = 474.37	5mg	QQ客服：1457312923
灵芝马酮; Ganodermanontriol	CFN99077	106518-63-2	C₃₀H₄₈O₄ = 472.7	20mg	QQ客服：1413575084
新化合物25; New compound 25	CFN95617	N/A	C₃₀H₄₆O₄ = 470.7	5mg	QQ客服：215959384
Lucialdehyde A; Lucialdehyde A	CFN90304	420781-84-6	C₃₀H₄₆O₂ = 438.69	5mg	QQ客服：215959384
灵芝醛A; Ganoderal A	CFN90306	104700-98-3	C₃₀H₄₄O₂ = 436.68	5mg	QQ客服：1457312923
灵芝酮A; Ganoderone A	CFN90303	873061-79-1	C₃₀H₄₈O₃ = 456.70	5mg	QQ客服：2056216494
赤芝二醇; Lucidadiol	CFN96840	252351-95-4	C₃₀H₄₈O₃ = 456.71	5mg	QQ客服：215959384
Lucidal; Lucidal	CFN92234	252351-96-5	C₃₀H₄₆O₃ = 454.7	5mg	QQ客服：2056216494
Lucialdehyde B; Lucialdehyde B	CFN90305	480439-84-7	C₃₀H₄₄O₃ = 452.67	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1993 mL	10.9963 mL	21.9925 mL	43.985 mL	54.9813 mL
5 mM	0.4399 mL	2.1993 mL	4.3985 mL	8.797 mL	10.9963 mL
10 mM	0.2199 mL	1.0996 mL	2.1993 mL	4.3985 mL	5.4981 mL
50 mM	0.044 mL	0.2199 mL	0.4399 mL	0.8797 mL	1.0996 mL
100 mM	0.022 mL	0.11 mL	0.2199 mL	0.4399 mL	0.5498 mL

灵芝醇F

Ganoderiol F

信息支持

联系方式