灵芝醇B

Ganoderol B

	产品编号	CFN99064
	CAS编号	104700-96-1
	分子式 = 分子量	C₃₀H₄₈O₂ = 440.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The fruiting body of Ganoderma lucidum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
灵芝醇B	CFN99064	104700-96-1	1mg	QQ客服：215959384
灵芝醇B	CFN99064	104700-96-1	5mg	QQ客服：215959384
灵芝醇B	CFN99064	104700-96-1	10mg	QQ客服：215959384
灵芝醇B	CFN99064	104700-96-1	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Almansora University (Egypt)

University of the Basque Country (Spain)

Center for protein Engineering (CIP) (Belgium)

Copenhagen University (Denmark)

Universidad Miguel Hernández (Spain)

University of Hawaii Cancer Center (USA)

Amity University (India)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

University of Medicine and Pharmacy (Romania)

National Cancer Center Research Institute (Japan)

Korea Institute of Oriental Medicine (Korea)

The Institute of Cancer Research (United Kingdom)

Harvard University (USA)

Osmania University (India)

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Description:

Ganoderol B is a potent α-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of α-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.

Targets:

Androgen Receptor

In vitro:

Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum

Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum[Pubmed: 21596546]

Abstract α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC(50) of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC(50) of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3,26-diol (ganoderol B). It was found to have high α-glucosidase inhibition, with an IC(50) of 48.5 μg/ml (119.8 μM). Copyright © 2011 Elsevier GmbH. All rights reserved.

In vivo:

Bioorg Med Chem. 2007 Jul 15;15(14):4966-72. Epub 2007 Apr 25.

The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.[Pubmed: 17499997]

Ganoderol B with 5alpha-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Lucidal; Lucidal	CFN92234	252351-96-5	C₃₀H₄₆O₃ = 454.7	5mg	QQ客服：3257982914
Lucialdehyde B; Lucialdehyde B	CFN90305	480439-84-7	C₃₀H₄₄O₃ = 452.67	5mg	QQ客服：1457312923
灵芝醇B; Ganoderol B	CFN99064	104700-96-1	C₃₀H₄₈O₂ = 440.7	5mg	QQ客服：2056216494
灵芝醇A; Ganoderol A	CFN99065	104700-97-2	C₃₀H₄₆O₂ = 438.7	5mg	QQ客服：1413575084
15,26-二羟基羊毛甾-7,9(11),24-三烯-3-酮; 15,26-Dihydroxylanosta-7,9(11),24-trien-3-one	CFN95604	420781-85-7	C₃₀H₄₆O₃ = 454.7	5mg	QQ客服：1413575084
灵芝醇F; Ganoderiol F	CFN99244	114567-47-4	C₃₀H₄₆O₃ = 454.7	5mg	QQ客服：215959384
灵芝萜酮二醇 ; Ganodermanondiol	CFN99085	107900-76-5	C₃₀H₄₈O₃ = 456.7	5mg	QQ客服：2056216494
灵芝醇A; Ganoderiol A	CFN80461	106518-61-0	C₃₀H₅₀O₄ = 474.37	5mg	QQ客服：2159513211
灵芝马酮; Ganodermanontriol	CFN99077	106518-63-2	C₃₀H₄₈O₄ = 472.7	20mg	QQ客服：3257982914
新化合物25; New compound 25	CFN95617	N/A	C₃₀H₄₆O₄ = 470.7	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2691 mL	11.3456 mL	22.6912 mL	45.3823 mL	56.7279 mL
5 mM	0.4538 mL	2.2691 mL	4.5382 mL	9.0765 mL	11.3456 mL
10 mM	0.2269 mL	1.1346 mL	2.2691 mL	4.5382 mL	5.6728 mL
50 mM	0.0454 mL	0.2269 mL	0.4538 mL	0.9076 mL	1.1346 mL
100 mM	0.0227 mL	0.1135 mL	0.2269 mL	0.4538 mL	0.5673 mL