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  • 灵芝醛A

    Ganoderal A

    灵芝醛A
    产品编号 CFN90306
    CAS编号 104700-98-3
    分子式 = 分子量 C30H44O2 = 436.68
    产品纯度 >=98%
    物理属性 White cryst.
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝醛A CFN90306 104700-98-3 1mg QQ客服:2159513211
    灵芝醛A CFN90306 104700-98-3 5mg QQ客服:2159513211
    灵芝醛A CFN90306 104700-98-3 10mg QQ客服:2159513211
    灵芝醛A CFN90306 104700-98-3 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Osmania University (India)
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  • Macau University of Science and Technology (China)
  • Universidad Miguel Hernández (Spain)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Med Food.2021, 24(3):209-217.
  • Current Pharmaceutical Analysis2017, 13(5)
  • Appl. Sci.2021, 11(24),12080
  • Food Res Int.2018, 106:909-919
  • Analytical sci. & Tech2020, 33(5):224-231
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Int J Mol Sci.2018, 19(9):E2528
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Am J Chin Med.2016, 44(6):1255-1271
  • Plant Cell Tiss Org2017, 479-486
  • Int J Mol Sci.2019, 20(14):E3538
  • FASEB J.2019, 33(2):2026-2036
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Front Cell Dev Biol.2020, 8:32.
  • Ind Crops Prod.2014, 62:173-178
  • J Nat Sc Biol Med2019, 10(2):149-156
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Food Chem.2019, 276:768-775
  • Food Chem.2020, 327:126992.
  • FEBS Lett.2015, 589(1):182-7
  • ACS Omega2020, 5,33,20825-20830
  • Chem Biol Interact.2016, 258:59-68
  • ...
  • 生物活性
    Description: The oxygenated sterols( 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y) from G. lucidum can inhibit cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol.
    In vitro:
    Appl Environ Microbiol. 2005 Jul;71(7):3653-8.
    Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.[Pubmed: 16000773]
    Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine.
    METHODS AND RESULTS:
    We report the isolation and identification of the 26-oxygenosterols ganoderol A, ganoderol B, Ganoderal A, and ganoderic acid Y and their biological effects on cholesterol synthesis in a human hepatic cell line in vitro. We also investigated the site of inhibition in the cholesterol synthesis pathway. We found that these oxygenated sterols from G. lucidum inhibited cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol. By incorporation of 24,25-dihydro-[24,25-3H2]lanosterol and [3-3H]lathosterol in the presence of ganoderol A, we determined that the point of inhibition of cholesterol synthesis is between lanosterol and lathosterol.
    CONCLUSIONS:
    These results demonstrate that the lanosterol 14alpha-demethylase, which converts 24,25-dihydrolanosterol to cholesterol, can be inhibited by the 26-oxygenosterols from G. lucidum. These 26-oxygenosterols could lead to novel therapeutic agents that lower blood cholesterol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.29 mL 11.45 mL 22.9001 mL 45.8001 mL 57.2502 mL
    5 mM 0.458 mL 2.29 mL 4.58 mL 9.16 mL 11.45 mL
    10 mM 0.229 mL 1.145 mL 2.29 mL 4.58 mL 5.725 mL
    50 mM 0.0458 mL 0.229 mL 0.458 mL 0.916 mL 1.145 mL
    100 mM 0.0229 mL 0.1145 mL 0.229 mL 0.458 mL 0.5725 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝醇A; Ganoderol A CFN99065 104700-97-2 C30H46O2 = 438.7 5mg QQ客服:2159513211
    灵芝醇F; Ganoderiol F CFN99244 114567-47-4 C30H46O3 = 454.7 5mg QQ客服:1148253675
    灵芝萜酮二醇 ; Ganodermanondiol CFN99085 107900-76-5 C30H48O3 = 456.7 5mg QQ客服:2159513211
    灵芝醇A; Ganoderiol A CFN80461 106518-61-0 C30H50O4 = 474.37 5mg QQ客服:2159513211
    灵芝马酮; Ganodermanontriol CFN99077 106518-63-2 C30H48O4 = 472.7 10mg QQ客服:1413575084
    Lucialdehyde A; Lucialdehyde A CFN90304 420781-84-6 C30H46O2 = 438.69 5mg QQ客服:3257982914
    灵芝醛A; Ganoderal A CFN90306 104700-98-3 C30H44O2 = 436.68 5mg QQ客服:2932563308
    灵芝酮A; Ganoderone A CFN90303 873061-79-1 C30H48O3 = 456.70 5mg QQ客服:2159513211
    赤芝二醇; Lucidadiol CFN96840 252351-95-4 C30H48O3 = 456.71 5mg QQ客服:3257982914
    Lucidal; Lucidal CFN92234 252351-96-5 C30H46O3 = 454.7 5mg QQ客服:1413575084

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