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  • 三尖杉宁碱

    Cephalomannine

    三尖杉宁碱
    产品编号 CFN98518
    CAS编号 71610-00-9
    分子式 = 分子量 C45H53NO14 = 831.91
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Diterpenoids
    植物来源 The barks of Cephalotaxus sinensis (Rehd. et Wils.) Li
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三尖杉宁碱 CFN98518 71610-00-9 10mg QQ客服:2159513211
    三尖杉宁碱 CFN98518 71610-00-9 20mg QQ客服:2159513211
    三尖杉宁碱 CFN98518 71610-00-9 50mg QQ客服:2159513211
    三尖杉宁碱 CFN98518 71610-00-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Canterbury (New Zealand)
  • Imperial College London (United Kingdom)
  • Stanford University (USA)
  • John Innes Centre (United Kingdom)
  • Korea Food Research Institute(KFRI) (Korea)
  • The Institute of Cancer Research (United Kingdom)
  • Massachusetts General Hospital (USA)
  • VIT University (India)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • The University of Newcastle (Australia)
  • Sant Gadge Baba Amravati University (India)
  • University of Medicine and Pharmacy (Romania)
  • Aarhus University (Denmark)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J of Apicultural Research2020, 10.1080
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Cells.2021, 10(11):2919.
  • Molecules.2019, 24(6):E1177
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Toxins (Basel).2022, 14(12):824.
  • China Pharmacy2015, 26(27)
  • J Agric Food Chem.2023, 71(47):18510-18523.
  • Food Chem.2019, 276:768-775
  • Phytomedicine.2023, 116:154841.
  • Front Pharmacol.2021, 12:764297.
  • J Nat Med.2020, 74(1):65-75
  • Korean J Dent Mater2020, 47(2):63-70.
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Mol Biol Rep.2022, doi: 10.1007
  • Life (Basel).2021, 11(12):1399.
  • Research on Crops.2017, 18(3):569
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Planta Med.2018, 84(6-07):465-474
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Front Pharmacol.2022, 13:883475.
  • Drug Chem Toxicol.2020, 1-14.
  • Natural Product Communications2020, doi: 10.1177.
  • ...
  • 生物活性
    Description: Cephalomannine is a taxol derivative with antitumor, antiproliferative properties, it shows cytotoxicity in human glial and neuroblastoma cell-lines.
    Targets: P450 (e.g. CYP17)
    In vitro:
    Int J Oncol. 1993 Feb;2(2):297-9.
    Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines.[Pubmed: 21573554]

    METHODS AND RESULTS:
    The cytotoxic effects of taxol, 10-deacetyltaxol, and cephalomannine at concentrations of 0.1 mug/ml to 10.0 mug/ml for one and 24 hours exposure were determined in two human glioblastoma multiforme and two neuroblastoma cell lines using the MTT method. The neuroblastoma cell lines were established from previously treated patients, while the glioblastomas were from untreated patients. There was a proportionate concentration-toxicity relationship for all four cell lines. The neuroblastoma SK-N-FI was consistently the most resistant to all three drugs. The order of potency after a one hour exposure was taxol, 10-deacetyltaxol and cephalomannine. Cephalomannine contained 1.5% taxol impurity and 10-deacetyltaxol, 4.5% taxol hence the contribution of taxol to these substances' toxic effects was minimal.
    CONCLUSIONS:
    We conclude that tumors of the central and peripheral nervous system are sensitive to 10-deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2021 mL 6.0103 mL 12.0205 mL 24.0411 mL 30.0513 mL
    5 mM 0.2404 mL 1.2021 mL 2.4041 mL 4.8082 mL 6.0103 mL
    10 mM 0.1202 mL 0.601 mL 1.2021 mL 2.4041 mL 3.0051 mL
    50 mM 0.024 mL 0.1202 mL 0.2404 mL 0.4808 mL 0.601 mL
    100 mM 0.012 mL 0.0601 mL 0.1202 mL 0.2404 mL 0.3005 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    多烯紫杉醇;多西他赛; Docetaxel CFN98517 114977-28-5 C43H53NO14 = 807.88 20mg QQ客服:215959384
    10-乙酰多西他赛; N-Debenzoyl-N-(tert-butoxycarbonyl)taxol CFN98516 125354-16-7 C45H55NO15 = 849.92 5mg QQ客服:215959384
    三尖杉宁碱; Cephalomannine CFN98518 71610-00-9 C45H53NO14 = 831.91 20mg QQ客服:1413575084
    10-去乙酰紫杉醇; Deacetyltaxol CFN90687 78432-77-6 C45H49NO13 = 811.87 20mg QQ客服:215959384
    7-表紫杉醇; 7-Epitaxol CFN90371 105454-04-4 C47H51NO14 = 853.91 20mg QQ客服:2056216494
    紫杉醇; Paclitaxel CFN97759 33069-62-4 C47H51NO14 = 853.92 20mg QQ客服:2056216494
    7-木糖基-紫杉醇; 7-Xylosyltaxol CFN98515 90332-66-4 C52H59NO18 = 986.0 5mg QQ客服:2056216494
    7-木糖甙-10-脱乙酰基紫杉醇; 10-Deacetyl-7-xylosyl paclitaxel CFN90837 90332-63-1 C50H57NO17 = 944.0 20mg QQ客服:2056216494
    7-表-10-去乙酰紫杉醇; 7-Epi-10-deacetyltaxol CFN89397 78454-17-8 C45H49NO13 = 811.86 20mg QQ客服:215959384
    7-Epi-10-deacetylcephalomannine ; 7-Epi-10-deacetylcephalomannine CFN89395 78479-12-6 C43H51NO13 = 789.86 5mg QQ客服:3257982914

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