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  • 7-表紫杉醇

    7-Epitaxol

    7-表紫杉醇
    产品编号 CFN90371
    CAS编号 105454-04-4
    分子式 = 分子量 C47H51NO14 = 853.91
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The barks of Taxus chinensis (Pilger) Rehd.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7-表紫杉醇 CFN90371 105454-04-4 10mg QQ客服:215959384
    7-表紫杉醇 CFN90371 105454-04-4 20mg QQ客服:215959384
    7-表紫杉醇 CFN90371 105454-04-4 50mg QQ客服:215959384
    7-表紫杉醇 CFN90371 105454-04-4 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Seoul National University (Korea)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2021, 10(9):1435.
  • Nutr Res Pract.2023, 17(4):670-681.
  • PLoS One.2017, 12(8):e0181191
  • Antioxidants (Basel).2020, 9(11):1121.
  • Korean J Acupunct2020, 37:104-121
  • Int J Oncol.2016, 49(4):1497-504
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Oncotarget.2016, 8(51):88386-88400
  • Biochem Pharmacol. 2020, 177:114014.
  • Nutrients.2018, 10(7)
  • Agriculture2022, 12(12), 2173.
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • Sci Rep.2021, 11(1):21038.
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • Molecules.2019, 24(24):E4536
  • J Sep Sci.2020, 43(22):4148-4161.
  • Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
  • Metabolites.2023, 13(5):625.
  • Eur J Pharmacol.2018, 832:96-103
  • Mol Med Rep.2024, 29(2):26.
  • Foods.2023, 12(2):318.
  • Appl. Sci.2023, 13(17), 9653.
  • ...
  • 生物活性
    Description: 7-Epitaxol is the major derivative of taxol found in cells and taxol (paclitaxel) is a well-known natural-source cancer drug.
    In vitro:
    J Pharmacol Exp Ther. 1987 Aug;242(2):692-8.
    Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium.[Pubmed: 2886648]
    The hydrolysis products of taxol have been isolated by high-performance liquid chromatography and identified by nuclear magnetic resonance and mass spectroscopy. In contrast to taxol, the major hydrolysis product, baccatin III, has little cytotoxic activity and does not promote in vitro microtubule assembly.
    METHODS AND RESULTS:
    In cell culture medium, the concentration of taxol decreases with time and 7-epitaxol, which exhibits properties comparable to those of taxol both on cells and on in vitro microtubuli polymerization, is formed. Baccatin III is found in small quantities in the cell medium, although it is barely detectable within the cells.
    CONCLUSIONS:
    It is concluded that 7-epitaxol is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1711 mL 5.8554 mL 11.7108 mL 23.4217 mL 29.2771 mL
    5 mM 0.2342 mL 1.1711 mL 2.3422 mL 4.6843 mL 5.8554 mL
    10 mM 0.1171 mL 0.5855 mL 1.1711 mL 2.3422 mL 2.9277 mL
    50 mM 0.0234 mL 0.1171 mL 0.2342 mL 0.4684 mL 0.5855 mL
    100 mM 0.0117 mL 0.0586 mL 0.1171 mL 0.2342 mL 0.2928 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    多烯紫杉醇;多西他赛; Docetaxel CFN98517 114977-28-5 C43H53NO14 = 807.88 20mg QQ客服:1413575084
    10-乙酰多西他赛; N-Debenzoyl-N-(tert-butoxycarbonyl)taxol CFN98516 125354-16-7 C45H55NO15 = 849.92 5mg QQ客服:3257982914
    三尖杉宁碱; Cephalomannine CFN98518 71610-00-9 C45H53NO14 = 831.91 20mg QQ客服:215959384
    10-去乙酰紫杉醇; Deacetyltaxol CFN90687 78432-77-6 C45H49NO13 = 811.87 20mg QQ客服:1457312923
    7-表紫杉醇; 7-Epitaxol CFN90371 105454-04-4 C47H51NO14 = 853.91 20mg QQ客服:3257982914
    紫杉醇; Paclitaxel CFN97759 33069-62-4 C47H51NO14 = 853.92 20mg QQ客服:3257982914
    7-木糖基-紫杉醇; 7-Xylosyltaxol CFN98515 90332-66-4 C52H59NO18 = 986.0 5mg QQ客服:215959384
    7-木糖甙-10-脱乙酰基紫杉醇; 10-Deacetyl-7-xylosyl paclitaxel CFN90837 90332-63-1 C50H57NO17 = 944.0 20mg QQ客服:1457312923
    7-表-10-去乙酰紫杉醇; 7-Epi-10-deacetyltaxol CFN89397 78454-17-8 C45H49NO13 = 811.86 20mg QQ客服:2159513211
    7-Epi-10-deacetylcephalomannine ; 7-Epi-10-deacetylcephalomannine CFN89395 78479-12-6 C43H51NO13 = 789.86 5mg QQ客服:2159513211

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