7-木糖甙-10-脱乙酰基紫杉醇
10-Deacetyl-7-xylosyl paclitaxel
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 7-木糖甙-10-脱乙酰基紫杉醇 |
CFN90837 |
90332-63-1 |
10mg |
QQ客服：2159513211 |
| 7-木糖甙-10-脱乙酰基紫杉醇 |
CFN90837 |
90332-63-1 |
20mg |
QQ客服：2159513211 |
| 7-木糖甙-10-脱乙酰基紫杉醇 |
CFN90837 |
90332-63-1 |
50mg |
QQ客服：2159513211 |
| 7-木糖甙-10-脱乙酰基紫杉醇 |
CFN90837 |
90332-63-1 |
100mg |
QQ客服：2159513211 |
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
10-Deacetyl-7-xylosyl paclitaxel has long been used in Chinese clinics to treat cancer, it may target mitochondrial permeability transition pore (mPTP). |
| In vitro: |
| Planta Med. 2010 Oct;76(14):1592-5. | | Transport of a hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel, by human intestinal epithelial Caco-2 cells.[Pubmed: 20414861 ] |
7-Xylosyl-10-deacetylpaclitaxel(10-Deacetyl-7-xylosyl paclitaxel) is an active compound used in traditional Chinese medicine to treat cancer. However, pharmacokinetic studies yielded low plasma concentrations of 7-xylosyl-10-deacetylpaclitaxel after its oral administration in preclinical trials.
Therefore, we investigated whether the observed low oral bioavailability of this compound is due to poor absorption.
METHODS AND RESULTS:
We studied the transepithelial flux of 7-xylosyl-10-deacetylpaclitaxel using the human colonic cell line Caco-2 as a model and found out that its flux (at a concentration range of 0.5-20 μM) across the Caco-2 cell layer was linear with time for up to 3 hr. The apparent maximal concentration (K (M)) of the active efflux component was 93.4 μM. Verapamil (50 μM) and tetrandrine (25 μM) significantly decreased the active transport component.
CONCLUSIONS:
These data support the conclusion that rapid passive diffusion of 7-xylosyl-10-deacetylpaclitaxel through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 7-xylosyl-10-deacetylpaclitaxel transport (16.3 ± 6.3 × 10 (-6) cm/s; n = 3) suggests that the drug may still be effectively absorbed in the intestinal tract. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.0593 mL |
5.2966 mL |
10.5932 mL |
21.1864 mL |
26.4831 mL |
| 5 mM |
0.2119 mL |
1.0593 mL |
2.1186 mL |
4.2373 mL |
5.2966 mL |
| 10 mM |
0.1059 mL |
0.5297 mL |
1.0593 mL |
2.1186 mL |
2.6483 mL |
| 50 mM |
0.0212 mL |
0.1059 mL |
0.2119 mL |
0.4237 mL |
0.5297 mL |
| 100 mM |
0.0106 mL |
0.053 mL |
0.1059 mL |
0.2119 mL |
0.2648 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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